ABSTRACT
We examined trabecular and cortical bone in the senescence-accelerated mouse prone 6 (SAMP6) murine model of senile osteoporosis after treatment with human PTH 1-34. Sixteen-week-old female SAMP6 mice were assigned to control and PTH groups. PTH (20 microg/kg) was administered sc 3 times a week for 12 weeks. The control mouse strain, senescence-accelerated mouse resistant 1 (SAMR1), was used for comparison. The femoral metaphysis and diaphysis were used to measure bone mineral density (BMD), analyze the trabecular and the cortical structure by micro-computed tomography, and for conducting the bone strength test. PTH significantly attenuated the loss of BMD, improved the trabecular bone microstructure, and increased the bone strength in the femoral metaphysis. We did not find any differences in the bone strength of the femoral diaphysis after PTH treatment, although the cortical bone volume and cortical thickness were improved. Although the cortical thickness increased, the cortical bone density decreased, likely because of the increase of cortical porosity in the distal metaphysis after administration of PTH.
Subject(s)
Bone Density/drug effects , Osteoporosis/physiopathology , Parathyroid Hormone/pharmacology , Animals , Bone and Bones/physiology , Disease Models, Animal , Female , Femur/drug effects , Humans , Mice , Mice, Inbred Strains , Parathyroid Hormone/administration & dosageABSTRACT
Chloral hydrate has been used extensively to sedate children, but at Brooke Army Medical Center, other drug combinations were becoming increasingly popular due to a perception that chloral hydrate had a high rate of failure, especially with younger or neurologically impaired children. Therefore, 50 children were given the drug before a diagnostic study, and patient data and a sedation score were recorded on a worksheet. Of 50 children, 43 (86%) were "successfully sedated" on the first attempt with no side effects. Children with neurologic disorders had a much greater (27% vs 4%) failure rate than "normal" children. The sedation rate did not significantly differ by age, sex, or initial drug dosage. The study suggest that chloral hydrate is a safe and effective oral sedative but that children with neurologic disorders may need alternative drugs for sedation.
Subject(s)
Chloral Hydrate/administration & dosage , Premedication , Administration, Oral , Adolescent , Child , Child, Preschool , Diagnostic Imaging , Drug Administration Schedule , Electroencephalography , Humans , InfantABSTRACT
A case of multicystic kidney diagnosed by computed tomography (CT) and confirmed at surgery is presented. On CT, the lesion appeared as an abnormal mass composed of numerous walled, low density areas of varying sizes consistent with the surgical finding of congenital multicystic kidney.
Subject(s)
Kidney Diseases, Cystic/diagnostic imaging , Tomography, X-Ray Computed , Female , Humans , Infant , Kidney Diseases, Cystic/pathologyABSTRACT
A right-sided cervical aortic arch, tetralogy of Fallot, and a peculiar tortuosity of the descending aorta in which the aorta formed triple loops were diagnosed by angiocardiography in a 12-year-old girl. Histologic examination of the biopsied wall of the left subclavian artery, taken at the time of a Blalock-Taussig anastomosis, revealed no elastic-tissue defect.
