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1.
Nihon Shokakibyo Gakkai Zasshi ; 115(1): 101-107, 2018.
Article in Japanese | MEDLINE | ID: mdl-29353846

ABSTRACT

Here, we report a case of adult gastric volvulus that was treated using an upper gastrointestinal series and provide a review of relevant reports. A 55-year-old woman presented with upper abdominal pain. Abdominal computed tomography revealed mesenteroaxial gastric volvulus. We performed an upper gastrointestinal series after the placement of a nasogastric tube. We successfully performed detorsion by repositioning. There was no recurrence of gastric volvulus after the detorsion. However, considering the risk of recurrence, we also performed laparoscopic gastropexy. The postoperative course was uneventful, and she was discharged from the hospital on postoperative day 3. No recurrence of symptoms has been observed to date.


Subject(s)
Stomach Volvulus/diagnosis , Abdominal Pain , Adult , Endoscopy , Female , Humans , Intubation, Gastrointestinal , Middle Aged , Stomach Volvulus/therapy , Tomography, X-Ray Computed
2.
Int J Surg Case Rep ; 16: 174-6, 2015.
Article in English | MEDLINE | ID: mdl-26479782

ABSTRACT

Here, we describe the case of a 58-year-old woman diagnosed with massive splenomegaly with a malignant lymphoma that had a maximum diameter of 24cm. Splenectomy was indicated because of thrombocytopenia and abdominal distention. Therefore, a balloon catheter was inserted preoperatively through the splenic artery for embolization and continuous infusion to reduce the spleen volume. It enabled easy handling of the spleen and minimized bleeding. The volume of the spleen was estimated at 1896g through the skin incision, as measured by volumetric computed tomography; thus, laparoscopy seemed difficult. However, the surgery was successfully performed only with laparoscopic surgery, and the volume of the resected spleen was 1020g. This preoperative preparation is an effective alternative to laparoscopic removal of a huge splenomegaly.

3.
World J Gastroenterol ; 18(16): 1940-5, 2012 Apr 28.
Article in English | MEDLINE | ID: mdl-22563175

ABSTRACT

AIM: To evaluate safety and feasibility of microcoil embolization of the common hepatic artery under proper or distal balloon inflation in preoperative preparation for en bloc celiac axis resection for pancreatic body cancer. METHODS: Fifteen patients (11 males, 4 females; median age, 67 years) with pancreatic body cancer involving the nerve plexus surrounding the celiac artery underwent microcoil embolization. To alter the total hepatic blood flow from superior mesenteric artery (SMA), microcoil embolization of the common hepatic artery (CHA) was conducted in 2 cases under balloon inflation at the proximal end of the CHA and in 13 cases under distal microballoon inflation at the distal end of the CHA. RESULTS: Of the first two cases of microcoil embolization with proximal balloon inflation, the first was successful, but there was microcoil migration to the proper hepatic artery in the second. The migrated microcoil was withdrawn to the CHA by an inflated microballoon catheter. Microcoil embolization was successful in the other 13 cases with distal microballoon inflation, with no microcoil migration. Compact microcoil embolization under distal microballoon inflation created sufficient resistance against the vascular wall to prevent migration. Distal balloon inflation achieved the requisite 1 cm patency at the CHA end for vascular clamping. All patients underwent en bloc celiac axis resection without arterial reconstruction or liver ischemia. CONCLUSION: To impede microcoil migration to the proper hepatic artery during CHA microcoil embolization, distal microballoon inflation is preferable to proximal balloon inflation.


Subject(s)
Embolization, Therapeutic/methods , Hepatic Artery , Pancreatic Neoplasms/therapy , Aged , Combined Modality Therapy , Female , Humans , Male
4.
World J Radiol ; 4(3): 121-5, 2012 Mar 28.
Article in English | MEDLINE | ID: mdl-22468194

ABSTRACT

Gastric varices are usually associated with a gastro-renal (G-R) shunt. However, the gastric varices described in this case report were not associated with a G-R shunt. The inflow vessel was the posterior gastric vein and the outflow vessels were the narrow inferior phrenic vein and the dilated cardio-phrenic vein. First, percutaneous transhepatic obliteration of the posterior gastric vein was performed, but the gastric varices remained patent. Then, micro-balloon catheterization of the subphrenic vein was carried out via the jugular vein, pericardial vein and cardio-phrenic vein, however, micro-balloon-occluded inferior phrenic venography followed by micro-coil embolization of the cardio-phrenic vein revealed no delineation of gastric varices resulting in no further treatment. Thereafter, as a gastro-subphrenic-intercostal vein shunt developed, a micro-balloon catheter was advanced to the gastric varices via the intercostal vein and balloon-occluded retrograde transvenous obliteration (BRTO) was performed resulting in the eradication of gastric varices. BRTO for gastric varices via the intercostal vein has not previously been documented.

5.
Jpn J Radiol ; 29(9): 649-55, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21956371

ABSTRACT

PURPOSE: The aim of the study was to clarify the effect of the interval between transcatheter hepatic arterial embolization (TAE) with Lipiodol plus gelatin sponge particles and radiofrequency (RF) ablation on the extent of ablation. MATERIALS AND METHODS: Eight healthy swine were divided into four groups: RF ablation (ablation only), RF ablation immediately after TAE (immediate ablation), RF ablation 3 days after TAE (3-day ablation), and RF ablation 6 days after TAE (6-day ablation). Five ablated lesions were created in each swine (10 per group). A 2-cm expandable LeVeen needle electrode was used for RF ablation. Ablated lesions are composed of an outer reddish zone and an inner whitish zone. RESULTS: The average longest length of the major, intermediate, and minor axes and the volume in the immediate ablation, 3-day ablation, and 6-day ablation groups were significant longer and greater (1.52 and 1.52, 1.46 and 1.50, and 1.37 and 1.35 times greater in the red zone and the whitish area, respectively) than those in the ablation-only group (P < 0.05/3). Accumulation of Lipiodol was still noted in the hepatic sinusoids in the 3-day and 6-day ablation groups. CONCLUSION: RF ablation delayed to 6 days following TAE produced larger ablation volumes than did RF ablation alone.


Subject(s)
Catheter Ablation/methods , Embolization, Therapeutic/methods , Liver/surgery , Animals , Ethiodized Oil/administration & dosage , Female , Gelatin Sponge, Absorbable/administration & dosage , Liver/pathology , Models, Animal , Swine , Time Factors
6.
J Vasc Interv Radiol ; 22(8): 1212-5, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21801997

ABSTRACT

Histologic evidence of safety after bronchial arterial embolization (BAE) with N-butyl cyanoacrylate (NBCA) should be assured. The present report describes a 78-year-old man with massive hemoptysis from lung cancer who underwent surgical lobectomy 23 days after hemostasis had been achieved via BAE with NBCA. Pathologic examination revealed that NBCA filled the lumen of bronchial branch arteries 143-1,094 µm in diameter from the lobar bronchus to subsegmental bronchus but was not seen in the lumen of the pulmonary artery or pulmonary vein. NBCA induced occlusion of bronchial branch arteries but no necrosis of the bronchial wall or pulmonary parenchyma.


Subject(s)
Bronchi/injuries , Bronchial Arteries/injuries , Embolization, Therapeutic/adverse effects , Enbucrilate/adverse effects , Hemoptysis/therapy , Lung Injury/etiology , Aged , Enbucrilate/administration & dosage , Ethiodized Oil/administration & dosage , Hemoptysis/etiology , Humans , Lung Neoplasms/complications , Male
7.
Cardiovasc Intervent Radiol ; 34(6): 1320-4, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21638146

ABSTRACT

A 60-year-old woman presented with a conglomerate pulmonary arteriovenous malformation (PAVM) size 8.2 × 7.2 cm on chest X-ray. Feeding arteries were A(a)(7) and A(b)(7) , A(8), and A(10). The diameter and length of the A(b)(7) neck were 15.5 and 16 mm, respectively. After percutaneous transcatheter embolization of A(8) and A(10), PTE of A(a)(7) and A(b)(7) was conducted under balloon occlusion with interlocking detachable coils using a technique of dumbbell-shaped framing and filling, making a bridge from A(b)(7) to the trunk of A(9) and A(10)across A(7). Follow-up computed tomography 10 months after treatment showed marked shrinkage of the PAVM.


Subject(s)
Arteriovenous Malformations/therapy , Catheterization , Embolization, Therapeutic/methods , Lung/parasitology , Arteriovenous Malformations/diagnosis , Diagnosis, Differential , Female , Humans , Middle Aged , Radiography, Interventional , Tomography, X-Ray Computed
8.
J Vasc Interv Radiol ; 22(7): 1039-44, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21708323

ABSTRACT

Two cases of portosystemic encephalopathy caused by an inferior mesenteric vein (IMV)-internal iliac vein shunt and an IMV-renal vein shunt are presented. IMV and systemic varicosity consisted of a first functional segment, a stagnant segment, and a second functional segment. Both patients underwent balloon occlusion retrograde transvenous obliteration (BRTO), using a microcatheter, to occlude the stagnant segment selectively. Although transient portal vein thrombosis was observed in case 1 and aggravation of esophageal varices was observed in case 2, these complications were tolerable. Following BRTO, the portosystemic encephalopathy in both cases resolved, and serum ammonia levels, although elevated, remained within the normal range.


Subject(s)
Balloon Occlusion , Esophageal and Gastric Varices/therapy , Hepatic Encephalopathy/therapy , Iliac Vein/physiopathology , Mesenteric Veins/physiopathology , Renal Circulation , Renal Veins/physiopathology , Splanchnic Circulation , Aged , Balloon Occlusion/adverse effects , Contrast Media , Esophageal and Gastric Varices/complications , Esophageal and Gastric Varices/diagnostic imaging , Esophageal and Gastric Varices/physiopathology , Female , Fluoroscopy , Hepatic Encephalopathy/diagnostic imaging , Hepatic Encephalopathy/etiology , Hepatic Encephalopathy/physiopathology , Humans , Iliac Vein/diagnostic imaging , Mesenteric Veins/diagnostic imaging , Phlebography , Radiography, Interventional , Renal Veins/diagnostic imaging , Tomography, X-Ray Computed , Treatment Outcome
9.
Cardiovasc Intervent Radiol ; 34(3): 609-14, 2011 Jun.
Article in English | MEDLINE | ID: mdl-20936284

ABSTRACT

PURPOSE: This study was designed to compare the strength among bone marrow nails created to treat long bone fractures using interventional procedures. METHODS: Twelve resected intact tibiae of healthy swine were used. A circumferential bone fracture was made in nine tibiae and restored with the following created bone marrow nails: acrylic cement alone (ACA) (n=3), acrylic-cement-filled bare metallic stent (AC-FBMS) (n=3), and acrylic-cement-filled covered metallic (AC-FCMS) stent (n=3). The remaining intact tibiae (n=3) were used as controls. RESULTS: A bone marrow nail was successfully achieved within 30 min in all swine. The maximum injection volume of acrylic cement for creating ACA, AC-FBMS, and AC-FCMS was 1.7±0.3, 3.2±0.4, and 2.9±0.4 mL, respectively. The thickness of bone marrow nail created in the ACA, AC-FBMS, and AC-FCMS groups was 3.6±1.0, 10.3±0.26, and 9.6±0.32 mm, respectively (AC-FBMS group versus AC-FCMS group, p=0.038), probably because of leakage of acrylic cement surrounding the interstices. The maximum bending power (kilonewton) and bending strength (newton/mm2) in the normal long bone, ACA, AC-FBMS, and AC-FCMS groups were: 1.70±0.25 and 79.2±16.1; 0.21±0.11 and 8.8±2.8; 0.46±0.06 and 18.2±1.6; and 0.18±0.04 and 7.8±2.7, respectively. CONCLUSIONS: Although the maximum bending power and bending strength of AC-FBMS were not satisfactory, it was the most robust of the three marrow nails for restoring fractured long bone.


Subject(s)
Bone Nails , Fracture Fixation/instrumentation , Stents , Tibial Fractures/surgery , Animals , Bone Cements , Bone Marrow , Bone Neoplasms/complications , Coated Materials, Biocompatible , Disease Models, Animal , Female , Fractures, Spontaneous/diagnostic imaging , Fractures, Spontaneous/surgery , Metals , Needles , Pain Measurement , Radiography, Interventional , Stress, Mechanical , Swine , Tibial Fractures/diagnostic imaging
10.
J Vasc Interv Radiol ; 21(9): 1436-41, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20800781

ABSTRACT

PURPOSE: To develop percutaneous osteoplasty with the use of a bone marrow nail for fixation of long-bone fractures, and to evaluate its feasibility and safety in vivo and in vitro. MATERIALS AND METHODS: Six long bones in three healthy swine were used in the in vivo study. Acrylic cement was injected through an 11-gauge bone biopsy needle and a catheter into a covered metallic stent placed within the long bone, creating a bone marrow nail. In the in vitro study, we determined the bending, tug, and compression strengths of the acrylic cement nails 9 cm long and 8 mm in diameter (N = 10). The bending strength of the artificially fractured bones (N = 6) restored with the bone marrow nail and cement augmentation was then compared with that of normal long bones (N = 6). RESULTS: Percutaneous osteoplasty with a bone marrow nail was successfully achieved within 1 hour for all swine. After osteoplasty, all swine regained the ability to run until they were euthanized. Blood tests and pathologic findings showed no adverse effects. The mean bending, tug, and compression strengths of the nail were 91.4 N/mm(2) (range, 75.0-114.1 N/mm(2)), 20.9 N/mm(2) (range, 6.6-30.4 N/mm(2)), and 103.0 N/mm(2) (range, 96.3-110.0 N/mm(2)), respectively. The bending strength ratio of artificially fractured bones restored with bone marrow nail and cement augmentation to normal long bone was 0.32. CONCLUSIONS: Percutaneous osteoplasty with use of a bone marrow nail and cement augmentation appears to have potential in treating fractures of non-weight-bearing long bones.


Subject(s)
Bone Cements/pharmacology , Bone Marrow/surgery , Bone Nails , Fracture Fixation, Internal/instrumentation , Humeral Fractures/surgery , Methylmethacrylate/pharmacology , Tibial Fractures/surgery , Animals , Biomechanical Phenomena , Biopsy/instrumentation , Catheterization , Catheters , Disease Models, Animal , Feasibility Studies , Fracture Fixation, Internal/adverse effects , Fracture Fixation, Internal/methods , Fracture Healing , Humeral Fractures/diagnostic imaging , Humeral Fractures/physiopathology , Materials Testing , Needles , Prosthesis Design , Radiography , Stents , Stress, Mechanical , Swine , Tibial Fractures/diagnostic imaging , Tibial Fractures/physiopathology , Time Factors
11.
Clin Nucl Med ; 35(9): 717-9, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20706051

ABSTRACT

A 59-year-old man presented with hemoptysis. Chest x-ray and computed tomography showed a cavitating mass and ground glass opacities in the right lower lobe. Positron emission tomography showed large regions of markedly increased fluorodeoxyglucose uptake in the right lower lobe consistent with primary cancer and intrapulmonary metastases, and several foci of high fluorodeoxyglucose uptake in the mediastinum and left neck consistent with lymph node metastases. We concluded that ground glass opacities were not aspiration of blood but intrapulmonary aerogenic metastases. Continuous active bleeding from the right bronchus (B6) was confirmed by bronchoscopy, and the right lower lobe was resected to remove the bleeding source. Pathologic findings showed pleomorphic carcinoma of the lung with intrapulmonary aerogenic metastases.


Subject(s)
Fluorodeoxyglucose F18 , Lung Neoplasms/diagnostic imaging , Neoplasm Metastasis/diagnostic imaging , Positron-Emission Tomography , Humans , Lung Neoplasms/pathology , Male , Middle Aged , Radiography, Thoracic , Whole Body Imaging
12.
Jpn J Radiol ; 28(5): 362-8, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20585924

ABSTRACT

PURPOSE: The aim of this study was to compare the safety and short-term efficacy of transcatheter arterial chemoembolization (TACE) using cisplatin-Lipiodol suspension (CP/Lp) with that using epirubicin-Lipiodol emulsion (EP/Lp) in patients with recurrent hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A total of 28 HCC patients were enrolled prospectively and assigned to the CP/Lp group or EP/Lp group. Adverse effects related to TACE were graded; and the treatment effect (TE) on HCC nodules at 3 months and overall tumor response at 6 months were assessed as the endpoint. RESULTS: No significant difference was observed between the groups regarding the frequency of adverse effects of grade 3 or less. The TE rates for 100% necrosis plus >50% necrosis in 62 HCC nodules in the CP/Lp group and 75 HCC nodules in the EP/Lp group were 72.6% and 66.7%, respectively (P = 0.894). Overall tumor response revealed that six patients (50.0%) in the CP/Lp group and six patients (37.5%) in the EP/Lp group had a partial response plus a complete response, with no significant difference (P = 0.615). TACE-free control curves for both groups revealed no significant difference (P = 0.513). CONCLUSION: No significant difference was found with regard to adverse effects, the treatment effect on HCC nodules, or overall tumor response between the CP/Lp and EP/Lp groups.


Subject(s)
Antibiotics, Antineoplastic/administration & dosage , Antineoplastic Agents/administration & dosage , Carcinoma, Hepatocellular/therapy , Chemoembolization, Therapeutic , Cisplatin/administration & dosage , Epirubicin/administration & dosage , Iodized Oil/administration & dosage , Liver Neoplasms/therapy , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Prospective Studies , Treatment Outcome
13.
Cardiovasc Intervent Radiol ; 33(6): 1192-7, 2010 Dec.
Article in English | MEDLINE | ID: mdl-20431886

ABSTRACT

This study was designed to compare the efficacy of transcatheter arterial embolization (TAE) with N-butyl cyanoacrylate (NBCA) or gelatin sponge particles (GSP) for acute arterial bleeding in a coagulopathic condition using a swine model. Four healthy swine were divided into two coagulopathic conditions: mild and severe. Five hemorrhages were created in each swine (10 hemorrhages per coagulopathy). Mild coagulopathy was achieved by bloodletting 10% of the total circulatory whole blood and preserving activated clotting time (ACT) less than 200 s (ACT < 200 s state); severe coagulopathy was achieved by bloodletting 30% and preserving ACT > 400 s (ACT > 400-second state). For each state, of ACT < 200 s or ACT > 400 s, TAE was conducted with GSP or NBCA to control five hemorrhages arising from artificially created renal and splenic injuries. Angiography immediately after TAE with GSP or NBCA showed complete occlusion in both coagulopathic conditions. In the ACT < 200-second state, follow-up angiography at 5-30 min after TAE with GSP or NBCA showed no evidence of recurrent hemorrhage. In the ACT > 400-second state, follow-up angiography showed recurrent hemorrhage in four (80%) of the five hemorrhages embolized with GSP and in one (20%) of the five hemorrhages embolized with NBCA. Microscopically, red thrombi were observed densely surrounding GSP in mild coagulopathy but were scarce in severe coagulopathy. In a condition with severe coagulopathy, TAE with NBCA was more effective in durability to cease active arterial bleeding than with GSP.


Subject(s)
Blood Coagulation Disorders/complications , Embolization, Therapeutic/methods , Enbucrilate/pharmacology , Gelatin Sponge, Absorbable/pharmacology , Hemorrhage/therapy , Renal Artery/injuries , Splenic Artery/injuries , Angiography , Animals , Disease Models, Animal , Hemostatics , Swine
14.
Cardiovasc Intervent Radiol ; 33(6): 1198-204, 2010 Dec.
Article in English | MEDLINE | ID: mdl-20431885

ABSTRACT

To prepare a soluble gelatin sponge (GS) and to explore the GS particles (GSPs) that inhibit development of collateral pathways when transcatheter hepatic arterial embolization is performed. The approval of the Institutional Committee on Research Animal Care of our institution was obtained. By means of 50 and 100 kDa of regenerative medicine-gelatin (RM-G), RM-G sponges were prepared by freeze-drying and heating to temperatures of 110-150°C for cross-linkage. The soluble times of RM-GSPs were measured in vitro. Eight swine for transcatheter hepatic arterial embolization were assigned into two groups: six received 135°C/50RM-GSPs, 125°C/100RM-GSPs, and 138°C/50RM-GSPs, with soluble time of 48 h or more in vitro; two swine received Gelpart GSPs (G-GSPs) with insoluble time of 14 days as a control. Transarterial chemoembolization was performed on two branches of the hepatic artery per swine. RM-GSPs heated at temperatures of 110-138°C were soluble. Mean soluble times of the RM-GSPs increased with higher temperature. Hepatic branches embolized with G-GSP remained occluded after 6 days, and development of collateral pathways was observed after 3 days. Hepatic branches embolized with 135°C/50RM-GSP and 125°C/100RM-GSP remained occluded for 4 h, and recanalization was observed after 1 day. Hepatic branches embolized with 138°C/50RM-GS remained occluded for 1 day, and recanalization was observed after 2 days with no development of collateral pathways. In RM-GSs with various soluble times that were prepared by modulating the heating temperature, 138°C/50RM-GSP was the soluble GSP with the longest occlusion time without inducing development of collateral pathways.


Subject(s)
Chemoembolization, Therapeutic/instrumentation , Gelatin Sponge, Absorbable/pharmacology , Hepatic Artery , Angiography , Animals , Chi-Square Distribution , Collateral Circulation , Female , Models, Animal , Swine , Temperature
15.
Cardiovasc Intervent Radiol ; 33(5): 1009-15, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20429002

ABSTRACT

This study was designed to assess the safety of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate-lipiodol (NBCA-Lp) for the large bowel and to investigate the vital response to NBCA-Lp in a swine model. In nine swine, nine arteries nourishing the colon were embolized with NBCA-Lp (1 ml of NBCA mixed with 4 ml of lipiodol): sigmoid-rectal branch artery in six swine, right colic branch artery in two, and middle colic branch artery in one. The amount of NBCA-Lp was 0.1-0.4 ml. Sacrifice was conducted 3 days after TAE to identify histological infarction. Classification was conducted retrospectively: group A, vasa recta without NBCA-Lp embolization despite TAE; group B, three or fewer vasa recta with NBCA-Lp embolization; and group C, five or more vasa recta with NBCA-Lp embolization. In one swine in group A, no necrotic focus was observed. In group B, three of four swine experienced no ischemic damage. The remaining one swine experienced necrosis of mucosal and submucosal layers in one-fourth of the circumference. In group C, all four swine with marginal artery and five vasa recta or more embolized experienced total necrosis of mucosa, submucosa, and smooth muscle layers of the whole colonic circumference. Significant difference on the extent of ischemic damage was observed between groups B and C (P < 0.05). Microscopically, NBCA-Lp induced acute vasculitis. Embolization of three or fewer vasa recta with NBCA-Lp induced no ischemic damage or limited necrosis, whereas embolization of five or more vasa recta with NBCA-Lp induced extensive necrosis.


Subject(s)
Colon/blood supply , Embolization, Therapeutic/adverse effects , Enbucrilate/pharmacology , Mesenteric Artery, Superior/pathology , Animals , Biopsy, Needle , Catheterization/methods , Colon/pathology , Colon, Sigmoid/blood supply , Colon, Sigmoid/pathology , Disease Models, Animal , Embolization, Therapeutic/methods , Enbucrilate/adverse effects , Female , Immunohistochemistry , Ischemia/etiology , Ischemia/pathology , Mesenteric Artery, Superior/drug effects , Probability , Random Allocation , Rectum/blood supply , Rectum/pathology , Risk Assessment , Statistics, Nonparametric , Swine
16.
Jpn J Radiol ; 28(2): 149-56, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20182850

ABSTRACT

PURPOSE: The purpose of this study was to assess the usefulness of triple-phase computed tomography during arterial portography (CTAP) using a bolus-tracking technique. MATERIAL AND METHODS: The subjects were 60 patients with hepatic tumors: 20 patients with metastatic liver tumors with a normal liver and 40 with hypervascular hepatocellular carcinoma (HCC) with liver cirrhosis. The region of interest was set in the portal vein, and CTAP was automatically started after the triggering threshold (180 HU) was reached. Three scans were performed: early phase (E), hepatic parenchymal phase (HP), and late phase (L). The scan start time of E-CTAP was measured. The detection rates of the HCC nodules were evaluated during each CTAP phase. RESULTS: CTAP was performed by bolus tracking without failure in any of the patients. The mean scan start times in the normal liver group and liver cirrhosis group were 14.3 +/- 1.34 s and 18.5 +/- 2.46 s, respectively, which were significantly different from each other. The detection rates of HCC nodules for E-CTAP, HP-CTAP, and L-CTAP were 29.6%, 100%, and 83.3%, respectively. CONCLUSION: The bolus-tracking technique enabled us to perform CTAP with optimal timing regardless of the portal blood flow dynamics.


Subject(s)
Carcinoma, Hepatocellular/diagnostic imaging , Contrast Media , Digestive System Neoplasms/diagnostic imaging , Liver Neoplasms/diagnostic imaging , Radiographic Image Enhancement/methods , Tomography, X-Ray Computed/methods , Aged , Carcinoma, Hepatocellular/complications , Carcinoma, Hepatocellular/pathology , Digestive System Neoplasms/complications , Digestive System Neoplasms/pathology , Female , Hepatitis C/complications , Humans , Imaging, Three-Dimensional/methods , Iodized Oil , Iohexol , Iopamidol , Liver/diagnostic imaging , Liver Cirrhosis/diagnostic imaging , Liver Cirrhosis/etiology , Liver Cirrhosis/pathology , Liver Neoplasms/pathology , Liver Neoplasms/secondary , Male , Middle Aged , Portal Vein/diagnostic imaging , Portography/methods , Sensitivity and Specificity , Time Factors
17.
Cardiovasc Intervent Radiol ; 33(2): 406-9, 2010 Apr.
Article in English | MEDLINE | ID: mdl-19484294

ABSTRACT

Embolization using N-butyl-2-cyano-acrylate (NBCA) has been highly regarded for treating pseudoaneurysm, arteriovenous malformation, and hemorrhage of the visceral arteries. We report the case of a patient who fell from a cliff and sustained hemorrhagic shock with blunt abdominal aortic rupture and who underwent embolization using NBCA. This treatment achieved immediate hemostasis and stabilization of vital signs. Although the long-term durability of NBCA is unknown, it appears that certain types of acute aortic hemorrhage with narrow-necked pseudoaneurysm can be controlled by embolization using NBCA.


Subject(s)
Acrylates/pharmacology , Aneurysm, False/therapy , Aorta, Abdominal/injuries , Embolization, Therapeutic/methods , Vena Cava, Inferior/injuries , Wounds, Nonpenetrating/therapy , Abdominal Injuries/diagnosis , Abdominal Injuries/therapy , Accidental Falls , Aged , Aneurysm, False/diagnostic imaging , Aorta, Abdominal/diagnostic imaging , Aortography/methods , Contrast Media , Emergency Service, Hospital , Follow-Up Studies , Humans , Injury Severity Score , Male , Multiple Trauma/diagnosis , Multiple Trauma/therapy , Radiographic Image Enhancement , Risk Assessment , Tomography, X-Ray Computed/methods , Treatment Outcome , Vena Cava, Inferior/diagnostic imaging , Wounds, Nonpenetrating/diagnostic imaging
18.
Cardiovasc Intervent Radiol ; 32(6): 1209-16, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19688368

ABSTRACT

The purpose of this study was to evaluate change in the portal systemic pressure gradient (PSPG) following balloon-occluded retrograde transvenous obliteration (BRTO) and the aggravation of esophageal varices. The PSPG was monitored before and after BRTO in 19 patients. PSPG changes were obtained by subtracting the PSPG before BRTO from that after BRTO. The development of outflow vessels (e.g., left inferior phrenic vein) was classified into two grades: Grade 1, BRTO alone; and Grade 2, coil embolization plus BRTO. After confirming demonstration of the whole gastric varices on angiography and computed tomography, BRTO was conducted using a 5% ethanolamine-iopamidol mixture. Endoscopy was performed to evaluate gastric and esophageal varices before, within 1 month, and 3-6 months after BRTO. Eradication of gastric varices was obtained in all patients and aggravation of esophageal varices was seen in 11 patients. The PSPG was significantly elevated by BRTO (p=0.0362). The PSPG was significantly elevated in patients with Grade 2 compared with those with Grade 1 (7.7+/-3.7 vs. 3.3+/-4.3 mmHg, respectively; p=0.0314) and in those with esophageal varices before treatment compared with those without (7.4+/-4.0 vs. 3.2+/-3.9 mmHg, respectively; p=0.0482). The cumulative aggravation rate of esophageal varices was significantly higher in 11 patients with a PSPG elevation>5 mmHg than in 8 patients with one of

Subject(s)
Balloon Occlusion/methods , Embolization, Therapeutic/methods , Esophageal and Gastric Varices/complications , Esophageal and Gastric Varices/therapy , Hypertension, Portal/etiology , Aged , Aged, 80 and over , Angiography , Balloon Occlusion/adverse effects , Contrast Media/administration & dosage , Embolization, Therapeutic/adverse effects , Esophageal and Gastric Varices/diagnostic imaging , Female , Follow-Up Studies , Humans , Iopamidol/administration & dosage , Male , Middle Aged , Proportional Hazards Models , Retrospective Studies , Sclerosing Solutions/administration & dosage , Tomography, X-Ray Computed , Treatment Outcome
19.
J Vasc Interv Radiol ; 20(10): 1359-64, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19695901

ABSTRACT

PURPOSE: To define the effects of hepatic artery chemoembolization with cisplatin-lipiodol suspension and gelatin sponge particles on swine liver tissue and estimate the concentration of cisplatin that would have a minimal negative effect on normal liver parenchyma. MATERIALS AND METHODS: Twelve pigs were divided into four groups: group A was the control group in which hepatic arteries were embolized with lipiodol and gelatin sponge particle (n = 3); group B animals were embolized with 10 mg/mL cisplatin-lipiodol suspension plus gelatin sponge particle (n = 3), group C with 20 mg/mL cisplatin-lipiodol suspension plus gelatin sponge particle (n = 3), and group D with 30 mg/mL cisplatin-lipiodol suspension plus gelatin sponge particle (n = 3). Pigs were euthanized 1 week after embolization, and the resected livers were cut into 10-mm-thick sections. The livers and necrotic foci were contoured in each section, and the necrosis volume ratio was calculated. RESULTS: The necrosis volume ratios of the livers in groups A, B, C, and D were 0.832% +/- 0.334, 2.324% +/- 1.126, 8.056% +/- 3.276, and 11.82% +/- 4.921, respectively. Significant differences (P < .05) in necrosis volume ratio were found between groups A and C, groups A and D, groups B and C, and groups B and D; no significant difference was found between groups A and B. CONCLUSIONS: Hepatic artery chemoembolization with higher doses of cisplatin causes greater damage to liver tissue; 10 mg/mL cisplatin-lipiodol suspension causes minimal damage, similar to that without cisplatin, and is related to minimal negative changes in a swine model.


Subject(s)
Chemoembolization, Therapeutic/adverse effects , Cisplatin/toxicity , Hemostatics/toxicity , Iodized Oil/toxicity , Liver/drug effects , Liver/pathology , Animals , Antineoplastic Agents/toxicity , Dose-Response Relationship, Drug , Suspensions/toxicity , Swine
20.
J Vasc Interv Radiol ; 20(9): 1176-87, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19643634

ABSTRACT

PURPOSE: To evaluate the outcome of transcatheter arterial embolization with gelatin sponge particles, microcoils, and N-butyl cyanoacrylate (NBCA) for acute arterial hemorrhage in the setting of coagulopathy. MATERIALS AND METHODS: Coagulopathy is defined by a platelet count less than 5 x 10(4)/microL and/or International Normalized Ratio (INR) greater than 1.5. Forty-six patients (31 male patients; mean age, 62 years) with acute arterial hemorrhage in a coagulopathic condition were treated by transcatheter arterial embolization with gelatin sponge particle, microcoils, and NBCA. RESULTS: Because of failure of hemostasis or recurrent hemorrhage, 10 patients who underwent gelatin sponge particle embolization also received transcatheter arterial embolization with microcoils or NBCA embolization and two patients who underwent microcoil embolization also received transcatheter arterial embolization with NBCA. The gelatin sponge particle group consisted of 27 hemorrhagic arteries in 25 patients, the microcoil group had 20 in 20 patients, and the NBCA group had 16 in 13 patients. The mean platelet count and mean INR value were 5.8 x 10(4)/microL +/- 3.5 and 1.81 +/- 0.50, respectively. The primary hemostatic rate, recurrent hemorrhage rate, and mean treatment time for the gelatin sponge particle, microcoil, and NBCA groups were 67%, 23%, and 25 minutes +/- 10; 80%, 0%, and 37 min +/- 19; and 100%, 0%, and 9 min +/- 4, respectively. Primary and secondary hemostasis were achieved in 50 (80%) and 60 (95%) of the 63 hemorrhagic arteries, respectively. Three hemorrhagic arteries in which transcatheter arterial embolization failed were treated with surgical repair. CONCLUSIONS: Although transcatheter arterial embolization with microcoils took a greater amount of time, transcatheter arterial embolization with NBCA or microcoils was more effective and feasible than that with gelatin sponge particle in terms of hemostasis and prevention of recurrent hemorrhage in a coagulopathic condition.


Subject(s)
Embolization, Therapeutic/instrumentation , Hemorrhage/therapy , Hemostatics/therapeutic use , Adult , Aged , Aged, 80 and over , Embolization, Therapeutic/methods , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Young Adult
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