ABSTRACT
Presence of asymptomatic joint involvement is recognized in patients with psoriasis. However, it remains elusive whether such patients develop psoriatic arthritis (PsA). The aim of the present study was to examine the incidence of asymptomatic joint lesions, in particular, enthesitis in patients with psoriasis vulgaris (PsV) and to further assess the clinical features. Eighteen PsV and 28 PsA patients were enrolled for examination by positron emission tomography/computed tomography (PET/CT) using (18) F-fluorodeoxyglucose (FDG). Any nail, scalp and intergluteal involvements were reported. Levels of serum C-reactive protein (CRP), white blood cell (WBC) counts and erythrocyte sedimentation rate (ESR) were examined. All of the PsA patients showed FDG accumulation in the affected joints. Notably, asymptomatic enthesitis was detected in six out of 18 PsV patients (33%), and they were diagnosed as having subclinical PsA. Incidences of scalp, intergluteal and nail psoriasis in subclinical PsA patients were 100%, 83% and 64%, respectively, which were higher than those in PsV patients (67%, 25% and 40%, respectively). CRP, WBC counts and ESR were invariable between PsV and subclinical PsA groups. PET/CT imaging could discover asymptomatic enthesitis. Our data suggested that the subpopulation of subclinical PsA was much higher than expected. Higher prevalence of nail, scalp and intergluteal psoriasis confirmed the risk of PsA as previously described.
Subject(s)
Arthritis, Psoriatic/diagnostic imaging , Positron Emission Tomography Computed Tomography , Adult , Aged , Arthritis, Psoriatic/epidemiology , Asymptomatic Diseases , Female , Fluorodeoxyglucose F18 , Humans , Incidence , Japan/epidemiology , Male , Middle AgedSubject(s)
Adenocarcinoma/diagnosis , Neoplasm Recurrence, Local/pathology , Skin Neoplasms/diagnosis , Stomach Neoplasms/pathology , Adenocarcinoma/secondary , Cellulitis/diagnosis , Humans , Lung Neoplasms/diagnostic imaging , Lymph Nodes/diagnostic imaging , Lymphatic Metastasis , Male , Middle Aged , Positron-Emission Tomography , Skin Neoplasms/secondarySubject(s)
Endothelin-1/biosynthesis , Keratinocytes/metabolism , Keratinocytes/radiation effects , Vitiligo/etiology , Vitiligo/metabolism , Adult , Endothelin-1/genetics , Female , Fibroblast Growth Factor 2/genetics , Humans , Male , Middle Aged , RNA, Messenger/genetics , RNA, Messenger/metabolism , Skin Pigmentation/radiation effects , Skin Transplantation , Stem Cell Factor/genetics , Ultraviolet Rays , Ultraviolet Therapy , Vitiligo/therapyABSTRACT
Enthesitis, defined as the inflammation of the origin and insertion of ligaments, tendons, aponeuroses, annulus fibrosis, and joint capsules, is a hallmark of spondyloarthritis (SpA). New imaging techniques including magnetic resonance imaging (MRI), ultrasonography, and positron emission tomography with computed tomography using 18F-fluorodeoxyglucose capable of detecting morphological and metabolic abnormalities and monitoring disease activity have improved the assessment and management of enthesitis of SpA.
Subject(s)
Diagnostic Imaging/methods , Inflammation/complications , Inflammation/diagnosis , Spondylarthritis/complications , Humans , Inflammation/diagnostic imaging , Magnetic Resonance Imaging , Multimodal Imaging , Positron-Emission Tomography , Tomography, X-Ray Computed , UltrasonographySubject(s)
Gene Expression Regulation , STAT3 Transcription Factor/metabolism , Skin/metabolism , Th17 Cells/cytology , Vitiligo/metabolism , Adult , Aged , Aged, 80 and over , Cell Proliferation , Female , Humans , Interleukin-6/metabolism , Keratinocytes/cytology , Langerhans Cells/cytology , Male , Middle Aged , Phosphorylation , Skin/physiopathology , Transforming Growth Factor beta/metabolism , Vitiligo/physiopathologySubject(s)
Drug Eruptions/etiology , ErbB Receptors/antagonists & inhibitors , Sebaceous Glands/drug effects , Antibodies, Monoclonal/pharmacology , Antibodies, Monoclonal, Humanized , Antineoplastic Agents/adverse effects , Ascorbic Acid/analogs & derivatives , Ascorbic Acid/pharmacology , Cells, Cultured , Cetuximab , Cytokines/genetics , Cytokines/metabolism , Drug Eruptions/genetics , Drug Eruptions/metabolism , Drug Eruptions/pathology , ErbB Receptors/metabolism , Humans , Keratinocytes/drug effects , Keratinocytes/pathology , Sebaceous Glands/metabolism , Sebaceous Glands/pathologyABSTRACT
Pseudoxanthoma elasticum is an inherited systemic disorder of connective tissue characterized by fragmentation of elastic fibers and calcification in cutaneous, ocular, and cardiovascular systems. Mutation in the ATP-binding cassette subfamily C member 6 gene has recently been found in people with pseudoxanthoma elasticum. However, the precise mechanisms of elastic fiber fragmentation and calcification remain obscure. Recently, it has been reported that mild chronic oxidative stress affects pseudoxanthoma elasticum fibroblasts. This suggests that reactive oxygen scavengers might improve this disorder.
Subject(s)
Antioxidants/therapeutic use , Ascorbic Acid/therapeutic use , Pseudoxanthoma Elasticum/drug therapy , alpha-Tocopherol/analogs & derivatives , Child, Preschool , Female , Humans , Pseudoxanthoma Elasticum/pathology , Tocopherols , alpha-Tocopherol/therapeutic useABSTRACT
Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mice in which contact dermatitis was developed by repeated application of diphenylcyclopropenone. Development of eczematous lesions in contact dermatitis was suppressed in histamine-deficient mice compared to wild-type mice. H(1) agonist ((6-12-(4-imidazol)ethylamino)-N-(4-trifluoro- methylphenyl)hepatanecarboxamide) promoted development of eczematous lesions in histamine-deficient mice. H(1) receptor antagonist (loratadine) suppressed development of eczematous lesions in wild-type mice, whereas H(2) agonist (dimaprit) and receptor antagonist (cimetidine) were ineffective. These results suggest that histamine facilitates the development of eczematous lesions in a murine model of contact dermatitis via H(1) receptors.
