1.
Angew Chem Int Ed Engl
; 50(25): 5674-7, 2011 Jun 14.
Article
in English
| MEDLINE
| ID: mdl-21557412
2.
Angew Chem Int Ed Engl
; 47(40): 7673-6, 2008.
Article
in English
| MEDLINE
| ID: mdl-18780362
3.
Chemistry
; 14(17): 5275-81, 2008.
Article
in English
| MEDLINE
| ID: mdl-18442032
ABSTRACT
For the synthesis of a 12-membered salicylic macrolide scaffold, ring-closing metathesis (RCM) of a omega-diene compound was planned. The stereochemical outcome of the RCM reaction changed depending on the type of Ru catalyst that was used; a "first-generation" Grubbs catalyst produced exclusively the E isomer and "second-generation" catalysts provided a mixture of the E and Z isomers under kinetic control (not thermodynamic control). Considerations for the E/Z selectivity are described.