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J Pediatr ; 129(6): 909-12, 1996 Dec.
Article in English | MEDLINE | ID: mdl-8969735

ABSTRACT

We describe a girl with hypothyroidism and blocking-type thyrotropin receptor antibodies that developed after chemotherapy and irradiation of the neck region for neuroblastoma. Results of thyroid studies before treatment were normal. Twenty months after completion of treatment, the girl had hypothyroidism with high titers of blocking-type thyrotropin receptor antibodies, antithyroglobulin, and antiperoxidase antibodies.


Subject(s)
Antibodies/blood , Autoimmune Diseases/etiology , Head and Neck Neoplasms/complications , Hypoparathyroidism/etiology , Neuroblastoma/complications , Peroxidase/immunology , Radiotherapy/adverse effects , Receptors, Thyrotropin/immunology , Thyroglobulin/immunology , Autoimmune Diseases/immunology , Binding, Competitive/radiation effects , Child, Preschool , Combined Modality Therapy , Female , Head and Neck Neoplasms/drug therapy , Head and Neck Neoplasms/radiotherapy , Humans , Hypoparathyroidism/immunology , Lymphatic Metastasis , Neuroblastoma/drug therapy , Neuroblastoma/radiotherapy , Peroxidase/radiation effects , Receptors, Thyrotropin/radiation effects , Thyroglobulin/radiation effects , Time Factors
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