ABSTRACT
Recently, a putative new pestivirus species, provisionally named as Atypical Porcine Pestivirus (APPV), was associated with the congenital tremor in piglets in North America and consequently in Europe and Asia. The present research aimed to describe the detection and characterization of APPV employing NS5B gene partial sequencing, gross pathology and histologic examination of piglets displaying congenital tremor from two different farms of Southern Brazil. No gross lesions were observed, and the histological findings revealed moderate vacuolization of the white matter of the cerebellum. RT-PCR followed by DNA sequencing and a phylogenetic analysis confirmed the presence of APPV in samples from the two farms, which the samples were distinct in nature. Phylogenetic reconstruction reinforced the high genetic variability within the APPVs previously reported. This is the first report of APPV in South America suggesting that this new group of viruses may be widespread in swine herds in other countries as it is in Brazil.
Subject(s)
Pestivirus/classification , Swine Diseases/virology , Tremor/veterinary , Animals , Brazil/epidemiology , Female , Pestivirus/genetics , Pestivirus/isolation & purification , Phylogeny , Sequence Analysis, DNA/veterinary , Swine , Swine Diseases/congenital , Swine Diseases/epidemiology , Tremor/congenital , Tremor/epidemiology , Tremor/virologyABSTRACT
O estudo PURE representa um dos maiores estudos de corte, envolvendo 150.000 indivíduos de áreas urbanas e rurais de 15 países. A má adaptação à urbanização, representada por variações no estilo de vida, fatores psicossociais e renda são determinantes independentes de fatores de risco cardiovascular
Subject(s)
Cardiovascular Diseases , Risk Factors , Environment , Rural Areas , Urban AreaABSTRACT
Twenty three patients with RA who have chronic renal insufficiency were post operatively studied for changes in the renal function with TKR (total knee replacement). We evaluated the renal function by BUN, Creatine, PSP and Creatine clearance. The renal function has not grown worse in all cases. TKR is a safe operation for renal function with careful technique and management.
