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Angew Chem Int Ed Engl
; 55(28): 8081-5, 2016 07 04.
Article
in English
| MEDLINE
| ID: mdl-27169816
ABSTRACT
Thiyl-radical-catalyzed cyclization reactions of N-tosyl vinylaziridines and alkenes were developed as a new synthetic method for the generation of substituted pyrrolidines. The key to making this process accessible to a broad range of substrates is the use of a sterically demanding thiyl radical, which prevents the undesired degradation of the catalyst.