ABSTRACT
1. The extent of phenformin absorption and its rate of urinary excretion have been assessed in adult patients with iron deficiency anaemia, a condition which compromises gastrointestinal function. 2. Phenformin (100 mg) was administered orally to patients before treatment, three days after the start of a course of iron treatment (oral 300 mg b.d. or total intravenous iron) and at the end of 28 days, when haemoglobin was over 10 gm%. 3. No significant difference was found between mean total amounts of phenformin and 4-hydroxyphenformin excreted in urine, before treatment or after 3 or 28 days replacement therapy. It is concluded that phenformin absorption is not affected by iron deficiency. 4. In addition, iron deficiency had no significant effect on phenformin elimination half-life.
Subject(s)
Anemia, Hypochromic/metabolism , Phenformin/pharmacokinetics , Adult , Humans , Intestinal Absorption , Iron/therapeutic use , Male , Phenformin/analogs & derivatives , Phenformin/urineABSTRACT
Ascariasis has been reported to impair the absorption of nutrients, vitamin A, and D-xylose, which is corrected on treatment. The effect of ascariasis and its treatment on the absorption of sulphadimidine and isoniazid has been investigated. There was no difference between drug absorption before and after the treatment or in comparison with a normal population.
Subject(s)
Ascariasis/metabolism , Isoniazid/pharmacokinetics , Sulfamethazine/pharmacokinetics , Ascariasis/drug therapy , Ascariasis/parasitology , Drug Interactions , Humans , Intestinal AbsorptionSubject(s)
Gene Frequency , Sulfamethazine/metabolism , Acetylation , Adult , Debrisoquin/metabolism , Female , Humans , India , Male , Middle Aged , PhenotypeABSTRACT
The effect of iron deficiency anaemia and its treatment on the absorption of sulphadimidine has been investigated in adult patients. The absorption judged by total % of the dose excreted in urine and Cmax, tmax, AUC and Kabs in plasma, was not significantly different before and after iron therapy or correction of anaemia. However, sulphadimidine absorption by the anaemic patients was significantly greater than in normals.
