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1.
BMJ Case Rep ; 17(3)2024 Mar 21.
Article in English | MEDLINE | ID: mdl-38514166

ABSTRACT

A term baby presented with cholestatic jaundice since birth. She was diagnosed as gestational alloimmune liver disease-neonatal haemochromatosis (GALD-NH) on evaluation. The baby received intravenous immunoglobulin (IVIG) and recovered gradually from the illness. She was also diagnosed with alpha thalassaemia during the course of evaluation, confirmed by genetic testing. NH is a very rare disorder that results in fetal loss or neonatal death due to liver failure. NH is now known to be a phenotypic expression of GALD. Worldwide, NH is seen in less than one in a million pregnancies. The mortality rate of GALD has traditionally been around 80% with almost all babies needing liver transplantation, with advent of maternal and neonatal IVIG treatment, this has reduced significantly. There is no reported case of GALD-NH treated successfully with IVIG from India. Here, we report an interesting case of GALD-NH with alpha thalassaemia.


Subject(s)
Fetal Diseases , Hemochromatosis , Infant, Newborn, Diseases , Liver Failure , alpha-Thalassemia , Pregnancy , Infant, Newborn , Female , Humans , Immunoglobulins, Intravenous/therapeutic use , alpha-Thalassemia/complications , alpha-Thalassemia/diagnosis , Hemochromatosis/complications , Hemochromatosis/diagnosis
2.
Indian J Pediatr ; 89(2): 192-194, 2022 Feb.
Article in English | MEDLINE | ID: mdl-34741254

ABSTRACT

This study evaluated the diagnostic role of cerebrospinal fluid leucine-rich alpha-2 glycoprotein (CSF LRG) concentration in children with acute bacterial meningitis, and its role in differentiation from aseptic meningitis. CSF LRG concentration was measured by ELISA Kit of 50 children with bacterial meningitis, 16 aseptic meningitis, and 20 children with normal CSF; control. CSF LRG was significantly elevated (p < 0.001) in bacterial meningitis with a sensitivity, specificity, PPV, and NPV of 96%, 100%, 100%, and 90.9%, respectively at a cutoff of 110.0 ng/mL, based on ROC curve. At the same cutoff value, CSF LRG has sensitivity, specificity, PPV, and NPV of 96%, 75%, 92.3%, and 85.7%, respectively in differentiating bacterial from aseptic meningitis. However, sensitivity, specificity, PPV, and NPV at 139.9 ng/mL for differentiating between definite and probable bacterial meningitis were 88%, 75%, 79.1%, and 84.9%, respectively. CSF LRG should be used as a diagnostic biomarker for bacterial meningitis.


Subject(s)
Meningitis, Aseptic , Meningitis, Bacterial , Biomarkers , Cerebrospinal Fluid , Child , Glycoproteins , Humans , Leucine , Meningitis, Aseptic/diagnosis , Meningitis, Bacterial/diagnosis
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