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1.
BMC Public Health ; 23(1): 2413, 2023 12 04.
Article in English | MEDLINE | ID: mdl-38049773

ABSTRACT

INTRODUCTION: Cervical cancer ranks as the third most prevalent cancer among women in Thailand. However, the effectiveness of cervical cancer screening programs is limited by several factors that impede the screening rate. The utilization of self-collected samples for screening purposes has the potential to alleviate barriers to screening in Thai women. This study assessed the cost-utility and budget impact of implementing cervical cancer screening using self-collected samples for human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing in Thailand. MATERIALS AND METHODS: We employed a decision tree integrated with a Markov model to estimate the lifetime costs and health benefits associated with the cervical cancer screening program for women aged 25-65. The analysis was conducted from a societal perspective. Four screening policy options were compared: (1) additional self-collected samples for HPV DNA testing, (2) clinician-collected samples for HPV DNA testing only, (3) clinician-collected samples for cytology test (i.e., status quo), and (4) no screening. The model inputs were based on unvaccinated women. The screening strategies and management in those with positive results were assumed followed to the Thai clinical practice guideline. Costs were reported in 2022 Thai baht. Sensitivity analyses were conducted. The ten-year budget impacts of the additional self-collected samples for HPV DNA testing were calculated from a payer perspective. RESULTS: All screening policies were cost-saving compared to no screening. When comparing the additional self-collected samples for HPV DNA testing with the clinician-collected samples policy, it emerged as the dominant strategy. The incremental benefit in cervical cancer prevention achieved by incorporating self-collected samples for screening was observed at any additional screening rate that could be achieved through their use. Sensitivity analyses yielded consistently favorable results for the screening policies. The average annual budget impact of the additional self-collected samples for screening policy amounted to 681 million Thai baht. This budget allocation could facilitate cervical cancer screening for over 10 million women. CONCLUSIONS: An addition of self-collected samples for HPV DNA testing into the cervical cancer screening program is cost-saving. The benefits of this screening policy outweigh the associated incremental costs. Policymakers should consider this evidence during the policy optimization process.


Subject(s)
Papillomavirus Infections , Uterine Cervical Dysplasia , Uterine Cervical Neoplasms , Female , Humans , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/prevention & control , Uterine Cervical Dysplasia/prevention & control , Early Detection of Cancer/methods , Thailand , Papillomavirus Infections/diagnosis , Papillomavirus Infections/prevention & control , DNA, Viral , Cost-Benefit Analysis , Mass Screening/methods
2.
PLoS One ; 18(11): e0291918, 2023.
Article in English | MEDLINE | ID: mdl-37972090

ABSTRACT

The purpose of this study was to determine direct and indirect costs of patients with trisomy (T) 13, 18, and 21 in Thailand. Direct medical costs were obtained from Siriraj Informatics and Data Innovation Center (SiData+), Faculty of Medicine, Siriraj Hospital, and indirect costs were estimated using a human capital approach. About 241 patients with T21 had outpatient care visits and 124 patients received inpatient care. For T13 and T18, five and seven patients were analyzed for outpatient and inpatient cares, respectively. For patients with T13, T18, and T21 receiving outpatient care, total annual mean direct medical costs ranged from 183.2 USD to 655.2 USD. For inpatient care, average yearly direct medical costs varied between 2,507 USD to 14,790 USD. The mean and median increased with age. In outpatient care, costs associated with drugs and medical devices were a major factor for both T13 and T21 patients, whereas laboratory costs were substantial for T18 patients. For inpatient care, costs of drug and medical devices were the greatest for T13 patients, while service fee and operation costs were the highest for T18 and T21 patients, respectively. For outpatient care, adult patients with congenital heart disease (CHD) had significantly higher mean annual direct medical costs than those without CHD. However, all adult and pediatric patients with CHD receiving inpatient care had significantly higher costs. Patients with T13, T18, and T21 had relative lifetime costs of 22,715 USD, 11,924 USD, and 1,022,830 USD, respectively.


Subject(s)
Chromosome Disorders , Heart Defects, Congenital , Adult , Humans , Child , Trisomy 13 Syndrome , Tertiary Care Centers , Thailand , Trisomy 18 Syndrome , Heart Defects, Congenital/surgery , Trisomy , Retrospective Studies
3.
PLoS One ; 18(9): e0291622, 2023.
Article in English | MEDLINE | ID: mdl-37713438

ABSTRACT

Historically, there has been a lack of cost-effectiveness data regarding the inclusion of universal non-invasive prenatal testing (NIPT) for trisomy 21, 18, and 13 in the benefit package of the Universal Health Coverage (UHC) in Thailand. Therefore, this study aimed to perform the cost-benefit analysis of prenatal screening tests and calculate the budget impact that would result from the implementation of a universal NIPT program. A decision-tree model was employed to evaluate cost and benefit of different prenatal chromosomal abnormalities screenings: 1) first-trimester screening (FTS), 2) NIPT, and 3) definitive diagnostic (amniocentesis). The comparison was made between these screenings and no screening in three groups of pregnant women: all ages, < 35 years, and ≥ 35 years. The analysis was conducted from societal and governmental perspectives. The costs comprised direct medical, direct non-medical, and indirect costs, while the benefit was cost-avoidance associated with caring for children with trisomy and the loss of productivity for caregivers. Parameter uncertainties were evaluated through one-way and probabilistic sensitivity analyses. From a governmental perspective, all three methods were found to be cost-beneficial. Among them, FTS was identified as the most cost-beneficial, especially for pregnant women aged ≥ 35 years. From a societal perspective, the definitive diagnostic test was not cost-effective, but the other two screening tests were. The most sensitive parameters for FTS and NIPT strategies were the productivity loss of caregivers and the incidence of trisomy 21. Our study suggested that NIPT was the most cost-effective strategy in Thailand, if the cost was reduced to 47 USD. This evidence-based information can serve as a crucial resource for policymakers when making informed decisions regarding the allocation of resources for prenatal care in Thailand and similar context.


Subject(s)
Down Syndrome , Prenatal Care , Pregnancy , Child , Female , Humans , Adult , Cost-Benefit Analysis , Thailand , Down Syndrome/diagnosis , Down Syndrome/genetics , Prenatal Diagnosis , Aneuploidy
4.
PLoS One ; 18(4): e0284829, 2023.
Article in English | MEDLINE | ID: mdl-37079630

ABSTRACT

This study evaluated prenatal screening test performance and the prevalence of common aneuploidies at Siriraj Hospital, Thailand. We collected data from screening tests which are first-trimester test, quadruple test, and noninvasive prenatal tests (NIPT) between January 2016 and December 2020. Thirty percent (7,860/25,736) of pregnancies received prenatal screening tests for aneuploidies disorders, and 17.8% underwent prenatal diagnosis tests without screening. The highest percentage of screening tests was first-trimester test (64.5%). The high-risk results were 4% for first-trimester test, 6.6% for quadruple test, and 1.3% for NIPT. The serum screening tests for trisomy 13 and 18 had no true positives; therefore, we could not calculate sensitivity. For the first-trimester test, the sensitivity for trisomy 21 was 71.4% (95% confidence intervals (CI) 30.3-94.9); specificity for trisomy 13 and 18 was 99.9% (95% CI 99.8-99.9); and for trisomy 21 was 96.1% (95% CI 95.6-96.7). For the quadruple test, the specificity for trisomy 18 was 99.6% (95% CI 98.9-99.8), while the sensitivity and specificity for trisomy 21 were 50% (95% CI 26.7-97.3) and 93.9% (95% CI 92.2-95.3), respectively. NIPT had 100% sensitivity and specificity for trisomy 13, 18 and 21, and there were neither false negatives nor false positives. For pregnant women < 35 years, the prevalence of trisomy 13, 18, and 21 per 1,000 births was 0.28 (95% CI 0.12-0.67), 0.28 (95% CI 0.12-0.67), and 0.89 (95% CI 0.54-1.45), respectively. For pregnant women ≥35 years, the prevalence of trisomy 13, 18, and 21 per 1,000 births was 0.26 (95% CI 0.06-1.03), 2.59 (95% CI 1.67-4.01), and 7.25 (95% CI 5.58-9.41), respectively. For all pregnancies, the prevalence of trisomy 13, 18, and 21 per 1,000 births was 0.27 (95% CI 0.13-0.57), 0.97 (95% CI 0.66-1.44), 2.80 (95% CI 2.22-3.52), respectively.


Subject(s)
Down Syndrome , Pregnancy , Female , Humans , Down Syndrome/diagnosis , Down Syndrome/epidemiology , Down Syndrome/genetics , Trisomy/diagnosis , Trisomy/genetics , Trisomy 13 Syndrome/diagnosis , Trisomy 13 Syndrome/epidemiology , Trisomy 13 Syndrome/genetics , Tertiary Care Centers , Prevalence , Thailand/epidemiology , Prenatal Diagnosis/methods , Aneuploidy , Trisomy 18 Syndrome/diagnosis , Trisomy 18 Syndrome/epidemiology
5.
J Obstet Gynaecol Can ; 44(11): 1153-1158, 2022 11.
Article in English | MEDLINE | ID: mdl-36096428

ABSTRACT

OBJECTIVE: To assess the frequency of emergency cesarean deliveries with decision-to-delivery intervals (DDIs) of less than 30 minutes after implementation of a code blue protocol following National Institute of Child Health and Human Development (NICHD) category III fetal heart rate (FHR) tracings. The secondary aim was to compare differences in pregnancy outcomes for deliveries completed before and after the 30-minute threshold. METHODS: All women undergoing a code blue emergency cesarean delivery between July 2015 and December 2021 were included. Information from electronic medical records, including baseline demographics, clinical characteristics, and pregnancy outcomes were retrospectively reviewed. RESULTS: Among 254 code blue cesarean deliveries, 246 (96.9%) had a DDI of ≤30 minutes. The median DDI was 17 (14.3-20.0) minutes. No significant differences in adverse maternal and neonatal outcomes were detected between deliveries with DDIs greater than and less than 30 minutes. The incidence of stillbirth was higher in the >30 minute-DDI group than in the ≤30 minute-DDI group (12.5% vs. 2%; P = 0.176). CONCLUSIONS: After implementation of a code blue protocol for emergency cesarean delivery, a DDI within 30 minutes was achieved in 97% of cases with category III FHR tracings. The incidence of stillbirth was dramatically higher in the >30 minutes-DDI group. We encourage all obstetric units to consider every factor that could reduce the DDI by developing specific, local protocols.


Subject(s)
Heart Rate, Fetal , Stillbirth , Pregnancy , Infant, Newborn , Child , Female , Humans , Retrospective Studies , Cesarean Section/methods , Pregnancy Outcome/epidemiology
6.
Am J Obstet Gynecol ; 227(2): 163-172, 2022 08.
Article in English | MEDLINE | ID: mdl-35263648

ABSTRACT

OBJECTIVE: This study investigated the efficacy and safety of pharmacologic interventions to prevent vertical transmission of the hepatitis B virus. DATA SOURCES: Medline, Cochrane, and Scopus databases were searched up to October 28, 2020. STUDY ELIGIBILITY CRITERIA: All randomized controlled trials reporting vertical hepatitis B virus transmission with pharmacologic intervention were included. METHODS: Risk of bias was assessed using the Cochrane Risk-of-Bias tool, version 2. Treatment efficacy was estimated using stratified network meta-analysis on the basis of maternal hepatitis B envelope antigen status. RESULTS: Nineteen studies were included for mothers positive for hepatitis B surface and envelope antigens. Pooling indicated that a combination of hepatitis B vaccination and hepatitis B immunoglobulin in infants significantly reduced transmission risk compared with vaccination alone, with a risk ratio of 0.52 (95% confidence interval; 0.30-0.91). Only the addition of maternal tenofovir disoproxil fumarate, but not telbivudine, lamivudine, or maternal hepatitis B immunoglobulin further reduced transmission risk compared with a combination of hepatitis B vaccination and hepatitis B immunoglobulin in infants, with a pooled risk ratio of 0.10 (0.03-0.35). Twelve studies conducted in mothers with hepatitis B surface antigen positivity and mixed, unknown, or negative hepatitis B envelope antigen status provided limited evidence to suggest that maternal hepatitis B immunoglobulin combined with hepatitis B vaccination and immunoglobulin in infants was the likely best treatment, but this failed to reach statistical significance compared with a combination of hepatitis B vaccination and immunoglobulin in infants. Similarly, infant hepatitis B immunoglobulin, added to vaccination, likely provides additional benefit but failed to reach statistical significance. CONCLUSION: A combination of hepatitis B vaccination and immunoglobulin in infants is the cornerstone for prevention of vertical transmission for mothers positive for both hepatitis B surface and envelope antigens. The addition of maternal tenofovir to this infant combination regimen was considered the likely most effective treatment. For infants of mothers with hepatitis B surface antigen positivity and mixed, unknown, or negative hepatitis B envelop antigen status, no additional agents provided further benefit beyond hepatitis B vaccination alone.


Subject(s)
Hepatitis B , Pregnancy Complications, Infectious , Antiviral Agents/therapeutic use , Female , Hepatitis B/prevention & control , Hepatitis B Surface Antigens/pharmacology , Hepatitis B Surface Antigens/therapeutic use , Hepatitis B virus , Humans , Immunoglobulins/therapeutic use , Infant , Infectious Disease Transmission, Vertical/prevention & control , Network Meta-Analysis , Pregnancy , Pregnancy Complications, Infectious/drug therapy , Pregnancy Complications, Infectious/prevention & control , Tenofovir/pharmacology , Tenofovir/therapeutic use , Viral Load
7.
JAMA Netw Open ; 5(1): e2143730, 2022 01 04.
Article in English | MEDLINE | ID: mdl-35029663

ABSTRACT

Importance: Meta-analyses have reported conflicting data on the safety of hormonal contraception, but the quality of evidence for the associations between hormonal contraceptive use and adverse health outcomes has not been quantified in aggregate. Objective: To grade the evidence from meta-analyses of randomized clinical trials (RCTs) and cohort studies that assessed the associations between hormonal contraceptive use and adverse health outcomes among women. Data Sources: MEDLINE, Embase, and the Cochrane Database of Systematic Reviews were searched from database inception to August 2020. Search terms included hormonal contraception, contraceptive agents, progesterone, desogestrel, norethindrone, megestrol, algestone, norprogesterones, and levonorgestrel combined with terms such as systematic review or meta-analysis. Evidence Review: The methodological quality of each meta-analysis was graded using the Assessment of Multiple Systematic Reviews, version 2, which rated quality as critically low, low, moderate, or high. The Grading of Recommendation, Assessment, Development and Evaluations approach was used to assess the certainty of evidence in meta-analyses of RCTs, with evidence graded as very low, low, moderate, or high. Evidence of associations from meta-analyses of cohort studies was ranked according to established criteria as nonsignificant, weak, suggestive, highly suggestive, or convincing. Results: A total of 2996 records were screened; of those, 310 full-text articles were assessed for eligibility, and 58 articles (13 meta-analyses of RCTs and 45 meta-analyses of cohort studies) were selected for evidence synthesis. Sixty associations were described in meta-analyses of RCTs, and 96 associations were described in meta-analyses of cohort studies. Among meta-analyses of RCTs, 14 of the 60 associations were nominally statistically significant (P ≤ .05); no associations between hormonal contraceptive use and adverse outcomes were supported by high-quality evidence. The association between the use of a levonorgestrel-releasing intrauterine system and reductions in endometrial polyps associated with tamoxifen use (odds ratio [OR], 0.22; 95% CI, 0.13-0.38) was graded as having high-quality evidence, and this evidence ranking was retained in the subgroup analysis. Among meta-analyses of cohort studies, 40 of the 96 associations were nominally statistically significant; however, no associations between hormonal contraceptive use and adverse outcomes were supported by convincing evidence in the primary and subgroup analyses. The risk of venous thromboembolism among those using vs not using oral contraception (OR, 2.42; 95% CI, 1.76-3.32) was initially supported by highly suggestive evidence, but this evidence was downgraded to weak in the sensitivity analysis. Conclusions And Relevance: The results of this umbrella review supported preexisting understandings of the risks and benefits associated with hormonal contraceptive use. Overall, the associations between hormonal contraceptive use and cardiovascular risk, cancer risk, and other major adverse health outcomes were not supported by high-quality evidence.


Subject(s)
Contraceptive Agents, Hormonal/adverse effects , Drug-Related Side Effects and Adverse Reactions/epidemiology , Long Term Adverse Effects/epidemiology , Women's Health/statistics & numerical data , Adult , Cohort Studies , Drug-Related Side Effects and Adverse Reactions/etiology , Female , Humans , Long Term Adverse Effects/chemically induced , Meta-Analysis as Topic , Pregnancy , Randomized Controlled Trials as Topic , Systematic Reviews as Topic
8.
J Obstet Gynaecol Res ; 47(2): 653-660, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33242918

ABSTRACT

AIM: To evaluate the impact of a mother-role development program on postpartum health-service utilization by adolescent mothers. METHODS: A single center, parallel, randomized, controlled, open-label trial using a computer-generated sequence was conducted at Siriraj Hospital. In all, 120 teenage mothers who delivered February 2015-December 2016 were randomized into experimental and control groups. The experimental group participated in a 2-year, mother-role development program at the Young Family Clinic. The two groups' characteristics, pregnancy outcomes and postpartum follow-up details over the 2-year period were compared. The main outcome measure was the utilization of maternal healthcare services (MHS). RESULTS: The teenage mothers were randomized into two groups of 60 participants each. Many were progressively lost to follow-up, leaving only 37 (experimental group, 19; control group, 18) for the intention-to-treat analysis. The results demonstrated a higher MHS utilization by the experimental group, but only at the 6-week postpartum follow-up. The usage of long-acting, reversible contraception (birth control implants and intrauterine devices) rose from 53.3% (immediate postpartum) to 95.5% (2 years postpartum). The two groups also had identical repeat pregnancy rates (6.67%; four participants in each), a marked decrease from 20% in a prior study. The breastfeeding rate was consistently higher among the mothers undertaking the mother-role development program. CONCLUSION: The program increased both MHS utilization during the initial postpartum period and the breastfeeding duration. Access to immediate postpartum contraception and long-acting, reversible contraception was associated with a reduction in repeat teen pregnancies. Having a multidisciplinary team was key to the health-service improvements.


Subject(s)
Mothers , Pregnancy in Adolescence , Adolescent , Breast Feeding , Contraception , Female , Humans , Postpartum Period , Pregnancy , Pregnancy in Adolescence/prevention & control
9.
BMC Health Serv Res ; 20(1): 975, 2020 Oct 26.
Article in English | MEDLINE | ID: mdl-33106169

ABSTRACT

BACKGROUND: The World Health Organization (WHO) recommends oxytocin as the drug of choice for postpartum hemorrhage (PPH) prevention. However, the WHO has also recently considered carbetocin for PPH prevention, but only if carbetocin were a cost-effective choice in the country. Consequently, we determined the cost-effectiveness and budgetary impact of carbetocin against oxytocin in the Philippines. METHODS: A cost-utility analysis using a decision tree was done to compare the costs and outcomes of carbetocin with oxytocin for PPH prophylaxis among women undergoing either vaginal delivery (VD) or cesarean section (CS) in a six-week time horizon using a societal perspective. One-way and probabilistic sensitivity analyses were applied to investigate parameter uncertainties. Additionally, budget impact analysis was conducted using a governmental perspective. Results were presented as incremental cost-effectiveness ratio (ICER) using a 2895 United States dollar (USD) per quality adjusted life year (QALY) gained as the ceiling threshold in the Philippines. RESULTS: Carbetocin was not cost-effective given the listed price of carbetocin at 18 USD. Given a societal perspective, the ICER values of 13,187 USD and over 40,000 USD per QALY gained were derived for CS and VD, respectively. Moreover, the ICER values were sensitive to the risk ratio of carbetocin versus oxytocin and carbetocin price. On budget impact, the five-year total budget impact of a drug mix of carbetocin and oxytocin was 25.54 million USD (4.23 million USD for CS and 21.31 million USD for VD) compared with 'only oxytocin' scenario. CONCLUSION: Carbetocin is not a cost-effective choice in PPH prevention for both modes of delivery in the Philippines, unless price reduction is made. Our findings can be used for evidence-informed policies to guide coverage decisions on carbetocin not only in the Philippines but also in other low and middle-income countries.


Subject(s)
Oxytocics , Postpartum Hemorrhage , Cesarean Section , Cost-Benefit Analysis , Female , Humans , Oxytocin/analogs & derivatives , Philippines/epidemiology , Postpartum Hemorrhage/drug therapy , Postpartum Hemorrhage/prevention & control , Pregnancy
10.
J Perinat Med ; 48(2): 102-114, 2020 Feb 25.
Article in English | MEDLINE | ID: mdl-31961794

ABSTRACT

Three-dimensional ultrasound (3DUS) may provide additional information for prenatal assessment of twins. It may improve the diagnostic confidence of dating, nuchal translucency (NT) and chorionicity assignment in twin pregnancies. The "virtual 3DUS placentoscopy" can guide selective fetoscopic laser photocoagulation (SFLP) to treat twin-twin transfusion syndrome (TTTS). Volumetric assessment of the dysmorphic acardiac twin with the Virtual Organ Computer-aided Analysis (VOCAL) software is more accurate than the conventional ultrasound measurement. Twin anemia polycythemia (TAP) sequence and selective intrauterine growth restriction (sIUGR) may be clinically monitored with 3DUS placental volume (PV) and power Doppler vascular indices. Congenital anomalies are more common in twins. Evaluation of fetal anomalies with 3DUS could assist perinatal management. The 3DUS power Doppler can provide a better understanding of true and false umbilical cord knots, which are commonly found in monoamniotic (MA) twins. Single demise in monochorionic (MC) twin pregnancies can cause severe neurologic morbidity in the surviving co-twin. Prenatal prediction of brain injury in the surviving co-twin with unremarkable neurosonographic examination is difficult. The 3DUS power Doppler may aid in prenatal detection of subtle abnormal cerebral perfusion. Prenatal assessment of conjoined twins with 3DUS is important if emergency postnatal surgical separation is anticipated. There is no significant additional advantage in using real-time 3DUS to guide prenatal interventions. Assessment of the cervix and pelvic floor during twin pregnancies is enhanced with 3DUS. Due to lack of high-quality studies, routine prenatal 3DUS in twin pregnancies needs to be balanced with risks of excessive ultrasound exposure.


Subject(s)
Imaging, Three-Dimensional , Pregnancy, Twin , Ultrasonography, Prenatal , Cerebral Palsy/diagnostic imaging , Female , Fetal Growth Retardation/diagnostic imaging , Fetofetal Transfusion/diagnostic imaging , Humans , Pregnancy
11.
J Perinat Med ; 45(7): 895-901, 2017 Oct 26.
Article in English | MEDLINE | ID: mdl-28665791

ABSTRACT

INTRODUCTION: Circulating soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) are potential markers for preeclampsia. The objective was to construct and analyse the reference ranges of serum levels of sFlt-1 and PlGF throughout the course of pregnancy in low-risk Thai pregnant women. METHODS: We enrolled 110 low-risk, Thai women singleton pregnancy from 10 to 40 gestational weeks. Serum concentrations of sFlt-1 and PlGF were measured with an automated assay. The reference ranges of serum levels of sFlt-1, PlGF and sFlt-1/PlGF ratio were constructed and assessed for possible correlations with gestational age, maternal factors [age, parity, tobacco use, artificial reproductive technologies (ARTS) and body mass index (BMI)], and pregnancy outcomes (gestational age at delivery, development of preeclampsia, neonatal birth weight and placental weight). RESULTS: None of the subjects developed preeclampsia. Serum sFlt-1 concentrations significantly elevated from 20 to 40 gestational weeks (P=0.003). Significant elevation and dropping of serum PlGF levels and sFlt-1/PlGF ratios were observed at 10 to 29 and 30 to 40 weeks of gestation, respectively (P<0.001). There was an inversed correlation between serum PlGF levels at 20 to 29 gestational weeks and neonatal birth weights (r=-0.48, P<0.05). There were no associations between serum levels of sFlt-1, PlGF, or sFlt-1/PlGF ratios and maternal BMI, gestational age at delivery, or placental weight (P>0.05). Effects from parity, smoking and ARTS were inconclusive. CONCLUSION: Robust change of serum PlGF levels suggests for its broader clinical application compared to sFlt-1. Prediction of preeclampsia using serum analytes may be gestational period specific.


Subject(s)
Placenta Growth Factor/blood , Pregnancy/blood , Vascular Endothelial Growth Factor Receptor-1/blood , Adult , Cross-Sectional Studies , Female , Humans , Reference Values , Young Adult
12.
J Obstet Gynaecol Res ; 41(9): 1345-51, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26111427

ABSTRACT

AIM: To compare the pregnancy outcome of patients diagnosed with gestational diabetes mellitus (GDM) using the Carpenter-Coustan (CC) criteria with that of non-GDM pregnant women at Siriraj Hospital, Bangkok. METHODS: A retrospective study was carried out by reviewing medical records of pregnant women who underwent 100-g oral glucose tolerance test (OGTT) for diagnosing GDM between January 2009 and December 2012 at Siriraj Hospital. Pregnant women were divided into three groups according to the 100-g OGTT result: group 1, pregnant women with normal OGTT on both CC and National Diabetes Data Group (NDDG) criteria; group 2, pregnant women with normal OGTT on NDDG criteria but GDM on CC criteria; and group 3, pregnant women with GDM on CC criteria after December 2012 and enrolled in glycemic control program. Maternal and perinatal outcomes were compared between the groups. RESULTS: During the study period, the incidence of GDM increased 32.76% using the CC criteria. These women (group 2) had a higher risk of neonatal hypoglycemia (6.7% vs 0.6%; OR, 12.3; P < 0.0001), neonatal hyperbilirubinemia (13.7% vs 7.8%; OR, 1.9; P = 0.013) compared with group 1. Pregnant women in group 3 had a lower incidence of immediate post-partum hemorrhage from vaginal delivery than group 2 (0 vs 2.9%; P = 0.04) as well as lower rates of neonatal hypoglycemia and neonatal hyperbilirubinemia. CONCLUSION: Use of CC criteria increases the prevalence of GDM, but managing these women according to the program for GDM can improve the adverse neonatal outcome.


Subject(s)
Blood Glucose/analysis , Diabetes, Gestational/diagnosis , Adult , Diabetes, Gestational/epidemiology , Female , Glucose Tolerance Test , Humans , Incidence , Pregnancy , Pregnancy Outcome , Retrospective Studies , Thailand
13.
J Obstet Gynaecol Res ; 40(4): 995-1001, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24428819

ABSTRACT

AIM: The aim of this study was to evaluate the effects of gestational weight gain on pregnancy outcomes in pregnant Thai women with different pre-pregnancy body mass indexes (BMI). MATERIALS AND METHODS: A retrospective study was carried out by reviewing 5200 medical records of pregnant women who delivered at the Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital during 1 September 2011-1 August 2012. Inclusion criteria were singleton pregnancy with available pre-pregnant weight and maternal height. Pre-pregnancy BMI were categorized according to World Health Organization criteria. Pregnancy outcomes of interest were appropriate-for-gestational-age infants. The optimal gestational weight gain for each BMI group was proposed to achieve a high proportion of appropriate-for-gestational age infants. RESULTS: Patients were divided into four groups according to their pre-pregnancy BMI: underweight (21.3%), normal weight (64.1%), overweight (11.5%), and obese (3.1%). Optimal gestational weight gain ranges for each group were 10-18, 8-16, 6-14 and 4-8 kg, respectively. Our proposed criteria seem to be realistic, with 60% of pregnant Thai women able to adhere to the recommendation, compared to 40.5% adherence to the 2009 Institute of Medicine recommendation. There were no significant complications when following either of the recommendations. Adverse pregnancy outcomes, including large for gestational age, cesarean section, and severe pre-eclampsia, were significantly decreased in women who complied with our recommendation. CONCLUSION: To achieve a high proportion of appropriate-for-gestational-age infants, Thai pregnant women could follow our gestational weight gain recommendation.


Subject(s)
Fetal Growth Retardation/etiology , Fetal Macrosomia/etiology , Maternal Nutritional Physiological Phenomena , Obesity/physiopathology , Overweight/physiopathology , Pregnancy Complications/physiopathology , Thinness/physiopathology , Adult , Body Mass Index , Female , Fetal Growth Retardation/epidemiology , Fetal Growth Retardation/ethnology , Fetal Growth Retardation/prevention & control , Fetal Macrosomia/epidemiology , Fetal Macrosomia/ethnology , Fetal Macrosomia/prevention & control , Health Promotion , Hospitals, University , Humans , Incidence , Maternal Nutritional Physiological Phenomena/ethnology , Nutrition Policy , Obesity/ethnology , Overweight/ethnology , Patient Compliance/ethnology , Pregnancy , Pregnancy Complications/ethnology , Pregnancy Outcome/ethnology , Retrospective Studies , Thailand/epidemiology , Thinness/ethnology , Weight Gain/ethnology , Young Adult
14.
Int J Gynaecol Obstet ; 124(2): 106-11, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24268355

ABSTRACT

OBJECTIVE: To assess the acceptability of implementing indicators of quality of care for severe pre-eclampsia/eclampsia to health providers, and to evaluate the effect of a multifaceted intervention on adherence to these indicators. METHODS: A multifaceted approach was used to implement indicators of quality of care for severe pre-eclampsia/eclampsia that were relevant to both district and referral hospitals. Healthcare providers at 9 hospitals in Southern Thailand rated the acceptability and priority of each indicator. In addition, medical records were reviewed before and after the intervention. RESULTS: More than 90% of the indicators were considered to be acceptable by the 145 health providers who participated in the study. After the intervention, adherence to most indicators was significantly increased. However, adherence after the intervention was lower than 80% for one-third of the indicators at district hospitals, compared with less than 10% of the indicators at referral hospitals. Common barriers to indicator implementation were lack of resources and skills, difficulty in making early and accurate diagnoses, and management. CONCLUSION: The indicators for the quality of care for severe pre-eclampsia/eclampsia were acceptable. Adherence to the indicators increased through a multifaceted intervention; however, the adherence varied considerably depending on the hospital referral level.


Subject(s)
Attitude of Health Personnel , Eclampsia/therapy , Pre-Eclampsia/therapy , Quality Indicators, Health Care , Adult , Female , Hospitals/standards , Humans , Male , Middle Aged , Personnel, Hospital , Pregnancy , Thailand
15.
J Healthc Qual ; 35(3): 22-34, 2013.
Article in English | MEDLINE | ID: mdl-22530567

ABSTRACT

Severe preeclampsia/eclampsia and postpartum hemorrhage (PPH) are serious obstetric problems worldwide. Quality improvement of care measured by evidence-based indicators is recommended as a recent important strategy; however, the indicators for quality of care of these two conditions have not been established. This study aimed to develop such indicators and assess their validity, reliability, and feasibility at different contextual levels. Of 32 initially valid indicators for care of severe preeclampsia/eclampsia, after two rounds of Delphi technique, 21 and 30 indicators were agreed to be suitable to monitor care at district and referral hospitals. Of 13 initial indicators for PPH, 8 and 13 indicators were selected, respectively. The interrater reliability of indicators varied from 0.28 to 0.63. At least three-fourths of all indicators rated by local doctors and nurses were assessed as feasible in terms of relevance, measurability, and improvability. The process identified reliable and feasible performance indicators to monitor quality of care in severe preeclampsia/eclampsia and PPH for either basic or comprehensive emergency obstetric care (EmOC). The informative applicability of these indicators in clinical practice needs further evaluation.


Subject(s)
Attitude of Health Personnel , Consensus , Obstetrics and Gynecology Department, Hospital/standards , Postpartum Hemorrhage/therapy , Pre-Eclampsia/therapy , Quality Indicators, Health Care/standards , Adult , Cross-Sectional Studies , Delphi Technique , Female , Humans , Male , Middle Aged , Multicenter Studies as Topic , Postpartum Hemorrhage/diagnosis , Pre-Eclampsia/diagnosis , Pregnancy , Quality Indicators, Health Care/organization & administration , Reproducibility of Results , Thailand , Workforce
16.
J Med Assoc Thai ; 95(10): 1244-51, 2012 Oct.
Article in English | MEDLINE | ID: mdl-23193735

ABSTRACT

OBJECTIVE: Assess the management and clinical outcomes of women diagnosed immediate PPH in three referral hospitals and six district hospitals in southern Thailand. MATERIAL AND METHOD: A cross-sectional study was done in participated hospital. Medical records of eligible cases were reviewed for management using evidence-based checklist. The adherence to each item of managements and the association between the management and related morbidities were analyzed. RESULTS: Medical records of 360 cases were assessed. Low adherence of retaining Foley catheter (44%) and close hemodynamic monitoring (67%) was found at district level. Retaining Foley catheter was demonstrated at referral level in 76% but performing uterine massage was documented in 67%. The adherence of managements was more likely to be found in cases with severe blood loss or received blood transfusion. CONCLUSION: Although low incidence of PPH was reported, incidence of blood transfusion, hypovolemic shock, and hysterectomy were not uncommon. Suboptimal care for hemodynamic monitoring and incomplete documentation of treatment need to be improved.


Subject(s)
Hospitals, District , Postpartum Hemorrhage/diagnosis , Postpartum Hemorrhage/therapy , Referral and Consultation , Adult , Clinical Audit , Clinical Protocols , Cross-Sectional Studies , Female , Humans , Postpartum Hemorrhage/epidemiology , Pregnancy , Thailand , Young Adult
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