Frozen shoulder. An overview of pathology and biology with hopes to novel drug therapies.

Frozen shoulder (FS) is a common disorder characterized by spontaneous onset of shoulder pain accompanied by progressive loss of range-of-motions. The cause of FS is still unclear, and radical therapy has not been established. With the final aim of preventing or curing FS at an earlier stage, we reviewed the pathological and biological features of this disease. Many studies indicate that the main pathology of FS is inflammation initially and fibrosis later. There are inflammatory cytokines, immune cells, fibrotic growth factors, and type-III collagen in the synovium and the joint capsule. The immune cell landscape switches from the macrophages to T cells. Activated fibroblasts seem to regulate the inflammatory and fibrotic processes. The imbalance between matrix metalloproteinases and tissue inhibitors of metalloproteases might promote fibrosis. Additionally, advanced glycation end-products are noted in the FS synovium. Diabetes mellitus and hypothyroidism are closely related to the development of FS. In terms of nonsurgical treatment, oral or intra-articular glucocorticoids are the only drugs that provide early benefit. Some other anti-inflammatory or antifibrotic drugs may potentially control the FS, but have not been proven effective in the clinical setting. Future studies should be targeted to develop steroid-sparing agents that inhibit biological events in FS.

Results 25 years after hemiarthroplasty for chondrolysis of the shoulder: A report of two cases.

Two patients (aged 34 and 52 years) underwent an open repair of concealed rotator cuff tear with the aid of colour arthrography using gentian violet. Postoperatively, they developed chondrolysis of the shoulder, which was treated with hemiarthroplasty. Twenty-five years after hemiarthroplasty, both patients showed good shoulder function without significant glenoid erosion on radiographs. Satisfactory long-term results are most probably due to maintenance of humeral head centring and glenohumeral conformity. These are the longest follow-up cases of arthroplasty for chondrolysis of the shoulder in the literature. We conclude that hemiarthroplasty can be a reasonable option for patients with this unfortunate disorder.

Midterm clinical outcomes of reverse shoulder arthroplasty in Japanese patients with rheumatoid arthritis using patient-reported outcome measures (Shoulder36).

BACKGROUND: Reverse shoulder arthroplasty normally has adequate functional outcomes in patients with cuff tear arthropathy. The present study aimed to investigate the midterm clinical outcomes of reverse shoulder arthroplasty in Japanese patients with rheumatoid arthritis. METHODS: Between July 2014 and May 2016, reverse shoulder arthroplasty was performed in 14 rheumatic shoulders with joint destruction and rotator cuff tears. The range of motion, Constant score, and Shoulder36, which is a patient-reported outcome measure, were compared preoperatively and postoperatively. The prevalence of subscapular notching, subscapular osteophytes, postoperative fractures, and stress shielding of the humeral stem were evaluated by X-ray. RESULTS: Range of motion significantly improved from 77 to 122 degrees in flexion and from 67 to 111 degrees in abduction at four years. The Constant score significantly improved from 27 to 62, and each domain of Shoulder36 also significantly increased at four years. There was no dislocation, infection, or loosening of the prosthesis. Three shoulders presented scapular notching, and three cemented humeral stems showed stress shielding in the proximal humeral cortical bone. CONCLUSION: Reverse shoulder arthroplasty performed in Japanese patients with rheumatoid arthritis not only decreased the pain and improved the function of the shoulder joint but also significantly improved patients' health and activity of daily living in midterm results.

A new pathophysiology of atraumatic rotator cuff tears: adduction restriction of the glenohumeral joint.

BACKGROUND: The pathophysiology of atraumatic rotator cuff tears (ATTs) has not been fully understood. Adduction restriction of the glenohumeral joint can cause pain and disability in patients with ATTs. We aimed to use our adduction test (pushing the humerus toward the side in the coronal plane with scapular fixation) to fluoroscopically measure the glenohumeral adduction angle (GAA) and to assess the effectiveness of adduction manipulation. MATERIALS AND METHODS: Fifty-five patients with ATTs were included in the study. The GAAs of the patients vs. healthy subjects without ATTs were measured fluoroscopically and compared. During the test, patients showed restriction and expressed pain. The visual analog scale (VAS) score, passive range of motion (ROM), and the American Shoulder and Elbow Surgeons score at the initial visit were compared with those after adduction manipulation. RESULTS: Of the patients, 41 (75%) had positive adduction test results. A higher percentage of positive adduction test results was observed in smaller tears. The average GAA was -21.4° on the affected side, which was smaller than that on the unaffected side, at -2.8° (P < .001), and that in healthy subjects, at 4.8° (P < .001). After manipulation, the GAA was -0.8° (P < .001) and the VAS score, the American Shoulder and Elbow Surgeons score, and all ROM values significantly improved up to the level on the unaffected side. CONCLUSION: Adduction restriction of the glenohumeral joint was identified in 75% of all the patients with ATTs. Adduction manipulation significantly reduces the VAS score and restores the ROM. Adduction restriction is considered a crucial pathophysiology of ATTs.

Representative survey of frozen shoulder questionnaire responses from the Japan Shoulder Society: What are the appropriate diagnostic terms for primary idiopathic frozen shoulder, stiff shoulder or frozen shoulder?

BACKGROUND: Primary frozen shoulder has unknown etiology and significant restriction of active and passive motion. The distinction between frozen shoulder and stiff shoulder has been unclear. Therefore, the purposes of this study were to perform a survey regarding definition and classification of frozen shoulder proposed by the American Academy of Orthopedic Surgeons (AAOS) among the members of the Japan Shoulder Society (JSS) and to compare the results with those obtained among the members of the American Shoulder and Elbow Surgeons (ASES). METHODS: The Scientific Research Project Committee of the JSS prepared the questionnaire for frozen shoulder and stiff shoulder. Surveys were sent by e-mail on Jan 14, 2016 to JSS registered members and the response dead-line was set on March 13, 2016. RESULTS: The number of respondents was 230, including all directors, councilors, and senior doctors. Agreement with the definition of primary frozen shoulder was 67%, the classification of primary or secondary frozen shoulder was 53%, and the 3 divisions of secondary frozen shoulder was 53%. Diagnostic terms for the cases of shoulder stiffness with unknown etiology were as follows: frozen shoulder (31%), stiff shoulder (22%), periarthritis scapulohumeralis (16%), so called "Gojukata" in Japan, which means shoulder problems in their fifties (16%), idiopathic frozen shoulder (6%), primary frozen shoulder (4%), adhesive capsulitis (3%), others (2%). CONCLUSION: The survey shows lower rates of agreement among the JSS members than the ASES members for the definition of primary frozen shoulder, the classification of primary and secondary frozen shoulder, and the divisions of secondary frozen shoulder. To avoid confusion between stiff shoulder and frozen shoulder, the committee agrees to the ISAKOS recommendation that the term "frozen shoulder" should be used exclusively for primary idiopathic stiff shoulder.

Isolated Coronal Shear Fracture of the Nonossified Humeral Trochlea in a 7-Year-Old Patient.

Coronal shear fractures of the nonossified humeral trochlea are extremely rare in skeletally immature children. This fracture is difficult to diagnose accurately on routine radiographs. In addition, the mechanism of injury and appropriate treatment methods are unknown. We present the case of a 7-year-old boy who sustained an isolated coronal shear fracture of the nonossified humeral trochlea. Internal fixation of the fracture was performed with 2 K-wires. Two and a half years after surgery, the patient had pain-free active range of motion of the elbow from 0° to 130° with full forearm rotation and magnetic resonance imaging showed healing of the chondral fragment of the trochlea. Hand surgeons should be aware of the possibility of this rare fracture in skeletally immature children. Magnetic resonance imaging and arthrography are helpful in establishing the correct diagnosis.

Treatment of hook of the hamate fractures in adults using low-intensity pulsed ultrasound.

Two delayed unions and one nonunion of hook of the hamate fractures in adults aged 31-, 40-, and 41-years-old were treated with low-intensity pulsed ultrasound (LIPUS). Ultrasound treatment was started at three, four, and six months after injury and ultrasound exposure at the hook of the hamate in the hypothenar eminence was carried out for four to five months. During the management period, there was no immobilisation with a cast or brace and limited strain with only routine daily activities allowed. In all cases, bony union was confirmed on carpal tunnel radiographs or computed tomography at the final follow-up time of eight and 36 months after injuries.

Primary frozen shoulder: brief review of pathology and imaging abnormalities.

BACKGROUND: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS. REVIEW OF LITERATURE: Many studies indicate that the main pathology is an inflammatory contracture of the shoulder joint capsule. This is associated with an increased amount of collagen, fibrotic growth factors such as transforming growth factor-beta, and inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. Immune system cells such as B-lymphocytes, T-lymphocytes and macrophages are also noted. Active fibroblastic proliferation similar to that of Dupuytren's contracture is documented. Presence of inflammation in the FS synovium is supported by the synovial enhancement with dynamic magnetic resonance study in the clinical setting. CONCLUSION: Primary FS shows fibrosis of the joint capsule, associated with preceding synovitis. The initiator of synovitis, however, still remains unclear. Future studies should be directed to give light to the pathogenesis of inflammation to better treat or prevent primary FS.

Pulmonary embolism after arthroscopic rotator cuff repair: a case report.

Total hip/knee arthroplasty may cause venous thromboembolism (VTE) as a postoperative complication. However, there are few reports on VTE after arthroscopic shoulder surgery. We report a patient who developed pulmonary embolism (PE) 6 days after arthroscopic rotator cuff repair but recovered without sequelae. In this case, the possibility of DVT of the lower limbs was denied by contrast-enhanced CT. Most possibly, the source of PE was deep vein thrombosis (DVT) of the upper limb under Desault fixation which showed arthroscopic surgery-related swelling postoperatively.

Stability of volar locking plate systems for AO type C3 fractures of the distal radius: biomechanical study in a cadaveric model.

BACKGROUND: The purpose of the present study was to compare the relative stability of five volar locking plates (all of which are available for the treatment of intraarticular fractures of the distal radius) under loading conditions simulating the physiological forces that occur during early active mobilization. METHODS: Five plating techniques were applied to surgically simulated AO type C3.2 distal radius fractures in formalin-fixed cadavers. The specimens were tested with a servohydraulic materials testing machine with 250 N of axial compression load for 3000 cycles. After cyclic loading, the specimens were loaded until they demonstrated failure in axial compression. The five fixation systems studied included a DRV locking plate (group 1), a Stellar plate (group 2), an Acu-Loc plate (group 3), AO Locking Distal Radius System 2.4 (group 4); and a Matrix SmartLock plate (group 5). RESULTS: None of the plate fixations tested failed during the cyclic loading. Group 2 had a higher elastic limit than groups 4 and 5. There were no significant differences among the five groups for the failure load. Failure occurred at the distal portion of the fixation system, at the ulnar side locking pin, or the locking screw was bent (groups 1, 2, 3); the ulnar side locking screw was broken (groups 3, 4); the locking screw became loose (group 4); and the ulnar side locking screw was uncoupled from the screw hole (group 5). CONCLUSIONS: All of the five volar plate fixation systems provided sufficient stability to permit 3000 repeated motions of the digits after surgery for AO type C3 distal radius fractures.

Different scapular kinematics in healthy subjects during arm elevation and lowering: glenohumeral and scapulothoracic patterns.

HYPOTHESIS: The scapulothoracic (ST) joint affects glenohumeral (GH) joint function. We observed 3-dimensional scapular motions during arm elevation and lowering to identify the scapulohumeral rhythm in healthy subjects and to compare it between the dominant and nondominant arms. MATERIALS AND METHODS: Twenty-one healthy subjects participated in this study. Participants randomly elevated and lowered the arms in the scapular plane, and data were recorded by a computerized 3-dimensional motion analyzer at each 10 degrees increment. RESULTS: Of the 42 shoulders, 21 showed a greater ratio of GH motion relative to ST motion whereas the other 21 showed a smaller ratio of GH motion relative to ST motion. The angle of upward rotation of the scapula showed a statistically significant difference between both types. The mean maximum angles of upward rotation, posterior tilting, and internal rotation were 36.2 degrees +/- 7.0 degrees , 38.7 degrees +/- 5.7 degrees , and 36.8 degrees +/- 12.2 degrees , respectively. No significant difference was found in angles of 3 scapular rotations between the dominant and nondominant arms. DISCUSSION: These results indicate that there are 2 distinctly different scapulohumeral rhythms in healthy subjects but without a significant difference between dominant and nondominant arms. These findings should be referred to when one is interpreting kinematics in a variety of shoulder disorders.

Analysis of the scapulohumeral rhythm and electromyography of the shoulder muscles during elevation and lowering: comparison of dominant and nondominant shoulders.

HYPOTHESIS: Assessment of whether elevation and lowering of the dominant and nondominant arms occur in a similar manner in healthy individuals is clinically important in terms of shoulder disorders. MATERIALS AND METHODS: We examined the scapulohumeral rhythm (SHR) and performed electromyography (EMG) for the middle deltoid, upper trapezius, lower trapezius, and lower part of the serratus anterior muscles of both shoulders in 18 healthy volunteers (14 men, 4 women) with a mean age of 24 years (range, 19-30 years). The participants randomly elevated and lowered either the right or left arm in the scapular plane, and the motion was measured using a 3-dimensional motion analyzer. RESULTS: The average angles of maximum arm elevation and scapular upward rotation were 130.3 degrees +/- 7.9 degrees and 32.2 degrees +/- 5.6 degrees, respectively, for dominant arms, and 130.8 degrees +/- 6.4 degrees and 31.8 degrees +/- 5.8 degrees, respectively, for nondominant arms. The SHR in each 10 degrees increment did not differ significantly between the dominant and nondominant arms in each participant during elevation (P = .337) and lowering (P = .1). A significant difference was found in the percentage integrated EMG (%IEMG) of the lower trapezius between the 2 shoulders (P < .049). DISCUSSION: If the kinematic difference is identified between both shoulders, we can predict the dysfunction or disorder in shoulder complex. Moreover, we should evaluate how shoulder muscles are used and whether the muscle becomes weak. CONCLUSIONS: Healthy individuals elevate and lower the dominant and nondominant shoulders in a similar kinematical pattern despite 3 of 4 muscles indicating different EMG activities between both shoulders.

Four-segment classification of proximal humeral fractures revisited: a multicenter study on 509 cases.

BACKGROUND: The 4-segment classification of Neer (1970) was revised in 2002 with the inclusion of valgus-impacted fractures. However, the range of possible fracture types covered by this classification is not clear. With the aim to clarify actual fracture patterns of the proximal humerus, a retrospective, multicenter study was conducted. METHODS: We retrospectively reviewed 509 cases for which anteroposterior and trans-scapular lateral views had been taken at the time of injury. Initially, three examiners from three facilities, independently read the radiographs of each case. In the second and third phases, for more difficult cases, consensus opinions were reached. RESULTS: We found that 501 (98%) of the 509 fractures had an appropriate category in the revised Neer classification. There were 185 cases (36%) of one-part fractures, followed by 156 cases (31%) of 2-part surgical neck fracture, 60 cases (12%) of 2-part greater tuberosity fracture (dislocation included), 45 cases (8.8%) of 3-part fracture involving the greater tuberosity and the surgical neck (dislocation included), 31 cases (6.1%) of 4-part fracture (dislocation included), and 17 cases (3.3%) of valgus-impacted fracture.Eight fractures (1.6%) could not be classified with the revised Neer classification. They were "3-part" fractures in terms of the number of displaced segments but had a complete anatomic neck fracture. CONCLUSION: We conclude that it would be appropriate to use the revised Neer classification in clinical practice. We would emphasize that, when there are 3 displaced segments, close attention should be paid to the fracture line on the anatomic neck. LEVEL OF EVIDENCE: Level 4; Diagnostic study, case series.

Prospective study of distal radius fractures treated with a volar locking plate system.

PURPOSE: To prospectively determine the results of treatment of distal radius fractures with a volar locking plate system with no bone graft and early mobilization. METHODS: Internal fixation and early mobilization of dorsally displaced, unstable fractures of the distal radius using a volar locking plate system without bone grafting was investigated in a prospective series of 49 fractures in 49 consecutive patients. All patients were allowed to move the wrist joint immediately after surgery. Physical examination at 5 weeks, 3 months, 6 months, and 1 year after the operation were performed. Radiographic parameters on preoperative, postoperative, and 1-year postoperative radiographs were compared. At 1-year review, the final clinical functions were evaluated with the Gartland and Werley functional scoring system, a modified Green and O'Brien system, and the Disabilities of the Arm, Shoulder, and Hand questionnaire. RESULTS: The average radiographic results at 1 year were 9 degrees of volar tilt; 22 degrees of radial inclination; 1 mm of ulnar variance, and 0 mm of articular incongruity. At 1-year review, an excellent or good result was found according to the system of Gartland and Werley and a modified Green and O'Brien system with scores of 100% and 98%, respectively. The Disabilities of the Arm, Shoulder, and Hand score averaged 6, indicating a high degree of patient satisfaction. There were no cases of infection, complex regional pain syndrome, tendon rupture, tendon irritation, nerve injury, or implant failure. CONCLUSIONS: The volar locking plate fixation without bone grafting and early mobilization is a safe and effective treatment for dorsally displaced, unstable fractures of the distal radius.

Persistent posterolateral rotatory subluxation of the elbow in cubitus varus: a case report.

A 23-year-old woman who had an episode of elbow injury which was treated cast immobilisation in childhood with residual cubitus varus sustained a posterior fracture dislocation of the same elbow. She was treated with closed reduction. Six months later, however, her elbow became stiff, and a persistent posterolateral rotatory subluxation was noted. Operations were performed in two steps; first, the radial head, which was subluxed posteriorly, was reduced and the lateral collateral ligament complex was reconstructed, and second, the stiff elbow was mobilised. Two years after the first surgery, the function of the elbow was satisfactorily recovered.

Effects of hyperbaric oxygen on gene expressions of procollagen, matrix metalloproteinase and tissue inhibitor of metalloproteinase in injured medial collateral ligament and anterior cruciate ligament.

Animal experiments were performed to investigate whether and how the administration of hyperbaric oxygen (HBO) affects gene expressions of procollagens, matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in injured medial collateral ligament (MCL) and anterior cruciate ligament (ACL). In 64 Sprague-Dawley rats, the MCL of the left knee was lacerated at the midsubstance, and the ACL of the left knee was lacerated adjacent to the tibial insertion in another 64 rats. Of these, 32 rats with lacerated MCL and 32 rats with lacerated ACL were housed in individual cages at normal atmospheric pressure (Groups MC and AC, respectively), while the remaining 64 rats were exposed to 100% oxygen at 2.5 atmospheres absolute for 2 h for 5 days a week (Groups MH and AH, respectively). Rats were sacrificed at 3, 7, 14 and 28 days postoperatively. After macroscopic examination, bilateral MCLs were harvested from Groups MC and MH, and bilateral ACLs from Groups AC and AH. Total RNA was extracted from each specimen and gene expressions of type I and type III procollagens, MMP-2, -9 and -3, and TIMP-1 and -2 were estimated using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Macroscopically, lacerated MCL healed by scar tissue formation, the amount of which appeared to be greater in Group MH than in Group MC. In contrast, no lacerated ACLs united, and little, if any, differences were apparent in macroscopic findings between Groups AH and AC. Gene expression of type I procollagen was significantly greater in Group MH than in Group MC at 7 days postoperatively and was also significantly greater in Group AH than in Group AC at 28 days (P<0.05). No significant differences in type III procollagen gene expression were noted between Groups MH and MC or between Groups AH and AC. In addition, no significant differences in gene expressions of MMPs were seen in either ligament, except that gene expression of MMP-13 was significantly lower at 7 days in Group MH than in Group MC (P<0.05). Gene expressions of TIMPs did not differ significantly between Groups MH and MC in each time interval, whereas gene expressions of TIMPs were significantly greater in Group AH than in Group AC at 7, 14 and 28 days for TIMP-1 and at 3, 7 and 14 days for TIMP-2 (P<0.05). RT-PCR results suggested that HBO enhances structural protein synthesis and inhibits degradative processes by enhancing TIMP activities in the lacerated ACL. However, none of the lacerated ACLs united macroscopically despite administration of HBO, indicating that the effect of HBO is insufficient for healing of the injured ACL. If HBO therapy is used as an adjunctive therapy after primary repair of the injured ACL, the success rate of surgery seems likely to be increased.

Malunited fractures of the distal radius treated with corrective osteotomy using volar locking plate and a corticocancellous bone graft following immediate mobilisation.

We describe our experience of using a volar locking plate for corrective osteotomy and bone grafting combined with early mobilisation in the treatment of distal radius malunions. Corrective osteotomy of the distal radius was performed through a volar approach, and fixated by a volar locking plate associated with corticocancellous iliac bone grafting in three patients aged 16, 71 and 75 years. Two patients had had volarly displaced malunion and one dorsally displaced malunion. Wrist motion was started immediately after surgery. The average follow-up was 15 months (range, 12-20 months). All osteotomies healed at an average 5.7 weeks post-operatively, resulting in a total arc of wrist motion of 133 degrees, forearm rotation of 167 degrees, and grip strength of 70% of that of the contralateral side. This treatment method proved to be effective and safe.

Histologic classification of loose bodies in osteoarthrosis.

BACKGROUND: Histologically based analyses of the nature and origin of loose bodies occurring in osteoarthrosis have been few, and further study is warranted. METHODS: We histologically examined 84 loose bodies and 9 related lesions (synovial membrane nodules) surgically removed from 24 joints of 24 patients with osteoarthrosis. RESULTS: The 84 loose bodies included 48 chondral loose bodies (type I), 26 osteochondral loose bodies (type II), and 10 osseous loose bodies (type III). The 26 osteochondral loose bodies (type II) could be subdivided into 8 composed of cartilage with enchondral ossification (type IIa), 11 consisting of mature bone covered by cartilage without enchondral ossification (type IIb), and 7 made up of mature bone and partially articular cartilage or hyaline cartilage (type IIc). Synovial membrane nodules could be also divided into three types in the same manner as loose bodies. Many type IIa, type IIc and type III loose bodies and all synovial membrane nodules showed blood vessels containing red blood cells, as well as osteoclasts. The type I and type IIb loose bodies, however, did not show them. CONCLUSIONS: It is well known that loose bodies grow from proliferation of cartilage without blood supply in the joint cavity, and that enchondral ossification is able to develop only under the condition of having a blood supply. As synovial membrane nodules were also classified to the same types as loose bodies and more than half of osteochondral and osseous loose bodies contained blood vessels with red blood cells, the loose bodies were thought to be caught in the synovial membrane and to be modified as the result of a blood supply. Considering the results of this study, the various histologic characteristics of loose bodies in osteoarthrosis resulted from modifications including cartilage proliferation in the joint cavity and enchondral ossification in the synovial membrane.