ABSTRACT
The purpose of this study was to evaluate the healing process of partial-thickness tears of the deep pectoral tendon in chickens which is considered to be equivalent to the human rotator cuff. The superior side (bursal-side) and the inferior side (joint-side) layers of the deep pectoral tendon of 80 adult chickens were lacerated in the same manner. The mRNA expression levels of alpha 1 (I) and alpha 1 (III) procollagen was at a level 2 weeks after laceration. The mRNA expression level of procollagen alpha 1 (I) was significantly higher than that of procollagen alpha 1 (III) in all experimental periods (p<0.05). The expression levels of procollagen-mRNAs were constitutively higher in bursal-side tears than in joint-side tears throughout the experimental periods (p<0.05), even 52nd weeks after laceration. These observations indicate that the bursal-side layer possesses higher healing ability than the joint-side layer in the chicken's deep pectoral tendon where subacromial impingement is absent, and that the remodeling of partial-thickness tears in chicken models needs more than one year.
Subject(s)
Gene Expression , Procollagen/genetics , RNA, Messenger/metabolism , Rotator Cuff Injuries , Tendon Injuries/metabolism , Animals , Chickens , Rotator Cuff/pathology , Rupture , Synovial Membrane/metabolism , Synovial Membrane/pathology , Tendon Injuries/pathologyABSTRACT
To clarify features of late vitamin K deficiency hemorrhagic disease in Japanese infants, seventeen of 1,687 infants screened by normotests were examined for signs and symptoms suggesting hepatobiliary diseases. Clinical observations disclosed findings suggesting hepatobiliary diseases in 7 of the 17 selected infants with normotest values of less than 40%, and 11 infants had abnormal results in one or more liver function tests. Taken together, 14 of the 17 infants had findings suggesting hepatobiliary diseases. Upon vitamin K supplementation normotest values improved in various degrees in all infants, whether or not they had signs or symptoms of hepatobiliary diseases. Late vitamin K deficiency hemorrhagic disease of infancy may be related to subclinical hepatobiliary diseases.
Subject(s)
Liver Diseases/etiology , Liver/physiopathology , Vitamin K Deficiency Bleeding/physiopathology , Female , Humans , Infant , Infant, Newborn , Liver Diseases/diagnosis , Liver Diseases/prevention & control , Liver Function Tests , Male , Mass Screening , Vitamin K/therapeutic use , Vitamin K Deficiency Bleeding/drug therapyABSTRACT
To determine a participation of cytomegalovirus (CMV) infection in acute respiratory tract disease (ARTD) of low-birth-weight (LBW) infants, specific antibodies against CMV antigens, IgG antibodies against early antigens of CMV (IgG EA) and IgM antibodies against membrane antigens of CMV (IgG MA) were analyzed. The frequency of IgG EA in patients with ARTD was higher than that in controls (46% vs. 32%), and the geometrical mean titer (GMT) of IgG EA in the patients was also higher than that in controls (50.2 vs. 20.1). Five of 15 ARTD patients had IgM MA, and the frequency was significantly higher than that of controls (33% vs. 1.3%, p less than 0.01). Eleven of 15 LBW patients with ARTD had a history of blood transfusions during the neonatal period, and 5 of them had significant IgM MA indicating active CMV infection. All 4 LBW patients without blood transfusion were negative for IgM MA. These results suggest a close relationship of CMV infection to ARTD of LBW infants, but it remains for further studies whether blood transfusion is a primary source of CMV infection in LBW infants.
Subject(s)
Cytomegalovirus Infections/complications , Immediate-Early Proteins , Infant, Low Birth Weight , Respiratory Tract Diseases/complications , Acute Disease , Antibodies, Viral/analysis , Antibody Specificity , Antigens, Viral/immunology , Cytomegalovirus/immunology , Female , Humans , Immunoglobulin E/analysis , Immunoglobulin M/analysis , Infant, Newborn , MaleABSTRACT
The following report is of a case of diffuse B-cell lymphoma of the anterior mediastinum that was originally treated by resection and radiation in a patient who had pleural and subcutaneous metastases four months after operation. A total dose of 120 mg of CDDP, 60 mg of BLM, and 15 mg of VBL was administered in five weeks. The metastases completely disappeared by this dose alone, and the patient is alive and well seven and a half years after the chemotherapy.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cisplatin/administration & dosage , Lymphoma/drug therapy , Mediastinal Neoplasms/drug therapy , Adolescent , B-Lymphocytes , Bleomycin/administration & dosage , Drug Administration Schedule , Female , Humans , Remission Induction , Vinblastine/administration & dosageABSTRACT
In a patient with Ph1-positive chronic myelogenous leukaemia (CML), the development of a localized blastoma preceding generalized blastic transformation was accompanied by a reduction of granulocyte-macrophage (GM) colony forming capacity in agar of bone marrow cells as well as an increase in peripheral neutrophil alkaline phosphatase (NAP) scores. Successful transplantation of the blastoma cells into nude mice enabled extensive studies of the cell properties. The blastoma cells were double Ph1-positive cells which did not respond to human granulocyte-macrophage colony-stimulating factor (GM-CSF), and were similar to cells demonstrated in spleen and bone marrow at the terminal stage of the patient's illness. These observations clearly support the case for sequential studies of colony formation in vitro as a useful test for the early detection of disturbances in marrow function that may occur before generalized blastic transformation. Studies of the properties of the blastoma cells also provide some insight into possible mechanisms for the transformation event.
