ABSTRACT
OBJECTIVE: The study was designed to compare the Pap smear results, performed on the public health service, with: the results of Pap smear collected on the reference service; the colposcopy and punch biopsy results. METHODS: The total of 213 women assisted at the women's hospital from January 1989 to April 1991, and followed until July 1998 were selected. Ninety were referred because a Pap smears suggestive of Human Papillomavirus (HPV) induced lesion or cervical intraepithelial neoplasia (CIN) grade 1, and 123, CIN 2 or 3. RESULTS: Among the 90 women referred because of HPV/CIN 1.49% presented CIN 2 or 3 in the Pap smears performed at this service. At the colposcopy, 16/90 women did not present suspicious lesions, and in 10 women, the squamous columnar junction was not observed. At biopsy, 42 (46%) presented CIN 2 or 3. Out of the 123 women referred with Pap smear of CIN 2 or 3.54% presented CIN 2 or 3 at this service. At the colposcopy, 24 women did not present suspicious lesions and the squamous columnar junction was not observed in 12. About biopsy, 61 (49%) presented CIN 2 or 3. CONCLUSIONS: The expectant conduct in cases of Pap smear with HPV/CIN 1, should follow a criterion, involving qualified professionals to collect the Pap smear, and should provide people awareness as to control follow-up.
Subject(s)
Papillomavirus Infections/pathology , Tumor Virus Infections/pathology , Uterine Cervical Dysplasia/pathology , Uterine Cervical Neoplasms/pathology , Uterine Cervicitis/pathology , Adolescent , Adult , Aged , Biopsy , Colposcopy/methods , Female , Follow-Up Studies , Humans , Middle Aged , Outcome Assessment, Health Care , Papanicolaou Test , Severity of Illness Index , Time Factors , Uterine Cervical Neoplasms/virology , Vaginal Smears , Uterine Cervical Dysplasia/virologyABSTRACT
A fine needle aspiration biopsy (FNAB) device was designed to utilize a steel spring located between the syringe and its plunger, which exerts a constant negative pressure (auto-vacuum). In 43 rats inoculated with breast tumour cells, the technique was compared with the standard procedure of FNAB (21 Sp1 and 22 Walker256 carcinosarcoma). Malignant cells were cytologically confirmed in all cases. Sufficient material was obtained in 95% of FNAB by auto-vacuum system versus 86% by standard technique. The superior results obtained with the auto-vacuum system was seen for both soft and hard tumours.
