ABSTRACT
In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.
Subject(s)
Boron Neutron Capture Therapy/methods , Radiometry/methods , Autoradiography , Cell Line, Tumor , Dose-Response Relationship, Radiation , HumansABSTRACT
In the present work, we show a successful approach to achieve stable structural and optical changes induced by pressure on bulk amounts of MAPI after pressure release. Such effects on the optical properties resemble those achieved in situ (e.g., in diamond anvil cells) but are retained and stabilized under ambient conditions thanks to a partial quenching of the high-pressure state.
