ABSTRACT
OBJECTIVE: To investigate if Neutrophil Gelatinase-associated Lipocalin can be used or not as a biochemical marker to determine the indications for emergency dialysis treatment. METHODS: The study was conducted at the Emergency Department of Numune Taraining and Research Hospital, Ankara, Turkey, in 2012, and comprised 60 patients who had uraemic symptoms and abnormal laboratory tests, including elevated potassium, blood urea nitrogen, and creatinine level or lowered pH and bicarbonate. They were divided in to 2 equal groups as those having indication for dialysis (Group 1) and those not having such indications (Group 2). Relevant values, including that of Neutrophil Gelatinase-associated Lipocalin, were compared between the two groups. To assess the utility of Neutrophil Gelatinase-associated Lipocalin measurements at varying cut-off values to predict indications for dialysis, a conventional receiver operating characteristic curve was generated and the area under the curve was calculated. P < 0.05 was considered statistically significant. RESULTS: The mean age of the 30 patients in Group 1 was 68.29 +/- 16.9 years, while in Group 2 it was 66.47 +/- 14.2 years (p < 0.65). The mean Neutrophil Gelatinase-associated Lipocalin level was 817.65 +/- 334.76ng/mL in Group 1 and 398.97 +/- 202.42 ng/mL in Group 2 (p < 0.001). The best cut-off level for Neutrophil Gelatinase-associated Lipocalin to predict emergency haemodialysis indication was 615 ng/mL with a sensitivity of 82% and a specificity of 80%, and the areas under curve was 0.84. CONCLUSION: Serum Neutrophil Gelatinase-associated Lipocalin level may be a determining parameter for indication of emergency haemodialysis.
Subject(s)
Acute Kidney Injury/diagnosis , Lipocalins/blood , Proto-Oncogene Proteins/blood , Renal Dialysis , Acute Kidney Injury/blood , Acute-Phase Proteins , Aged , Aged, 80 and over , Biomarkers/blood , Emergency Medical Services , Humans , Lipocalin-2 , Middle Aged , ROC CurveABSTRACT
OBJECTIVE: To investigate the value of serum Mean Platelet Volume in acute ischaemic stroke patients. METHOD: The retrospective case-control study was conducted at Ankara Numune Training and Research Hospital in Turkey and comprised record of patients of acute ischaemic stroke admitted to the Emergency Department between June 2010 and January 2012. The two groups were statistically compared using SPSS 18.0. RESULT: Overall, there were 482 stroke patients (Group 1) and 315 subjects as controls (Group 2). The median value in Group 1 was 9.0 (2.1) (fL), while in Group 2 it was 8.80 (2.4) (fL).The difference was statistically significant (Z = -2.80; p < 005). CONCLUSION: Mean Platelet Volume increased in the stroke patients.
