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ACS Appl Mater Interfaces ; 5(17): 8263-6, 2013 Sep 11.
Article in English | MEDLINE | ID: mdl-23952053

ABSTRACT

Gold nanoparticles (GNPs) that can release nitric oxide (NO) on visible-light irradiation were prepared using 2-mercapto-5-nitro benzimidazole (MNBI) as stabilizer. These nanoparticles meet overall prerequisites for biomedical applications like small sizes, water solubility, and stability. It was found that even a very low dosage of MNBI-stabilized GNPs exhibit appreciable tumor cell mortality against cervical cancer cell lines, demonstrating the role of NO in killing cancer cells.


Subject(s)
Gold/chemistry , Light , Metal Nanoparticles/chemistry , Nitric Oxide/metabolism , Apoptosis/drug effects , Benzimidazoles/chemistry , Female , HeLa Cells , Humans , Metal Nanoparticles/therapeutic use , Metal Nanoparticles/toxicity , Solubility , Uterine Cervical Neoplasms/drug therapy , Uterine Cervical Neoplasms/metabolism , Uterine Cervical Neoplasms/pathology , Water/chemistry
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