1.
J Antibiot (Tokyo)
; 29(5): 507-10, 1976 May.
Article
in English
| MEDLINE
| ID: mdl-956038
ABSTRACT
The strain Actinoplanes garbadinensis nov. sp. produces a peptide antibiotic, named gardimycin, which is active in vitro and in vivo against Gram-positive bacteria. Isolation and purification of the product have been accomplished by extraction from the broth with butanol and dialysis of the crude extract, followed by counter-current distribution. Gardimycin is an open chain peptide with an approximate minimal formula C84H138N18S3-4O34Na. The following amino acids have been identified by column chromatography of an acid hydrolysate: serine, glutamic acid, alanine, leucine, isoleucine, glycine, valine and two sulphur-containing amino acids whose structure is presently under study. Tryptophan has been identified in an alkaline hydrolysate.
Subject(s)
Anti-Bacterial Agents , Actinomycetales , Amino Acids/analysis , Anti-Bacterial Agents/analysis , Anti-Bacterial Agents/isolation & purification , Chemical Phenomena , Chemistry , Chromatography, Paper , Chromatography, Thin Layer , Crystallization , Culture Media/analysis , Hydrolysis
2.
J Antibiot (Tokyo)
; 26(1): 1-6, 1973 Jan.
Article
in English
| MEDLINE
| ID: mdl-4781275
Subject(s)
Actinomycetales/analysis , Anti-Bacterial Agents/isolation & purification , Lactones/isolation & purification , 4-Butyrolactone/analogs & derivatives , Actinomycetales/cytology , Actinomycetales/metabolism , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Carbon/metabolism , Cell Wall/analysis , Chemical Phenomena , Chemistry , Chemistry, Physical , Chromatography, Paper , Furans/isolation & purification , Microscopy, Electron, Scanning , Spectrophotometry, Infrared
3.
J Antibiot (Tokyo)
; 24(8): 491-6, 1971 Aug.
Article
in English
| MEDLINE
| ID: mdl-4937286
Subject(s)
Anti-Bacterial Agents/isolation & purification , Pyrroles/isolation & purification , Streptomyces/analysis , Acrylamides/biosynthesis , Acrylamides/isolation & purification , Acrylamides/pharmacology , Anti-Bacterial Agents/biosynthesis , Anti-Bacterial Agents/pharmacology , Carbohydrate Metabolism , Chromatography, Paper , Chromatography, Thin Layer , Culture Media , Escherichia coli/drug effects , Microbial Sensitivity Tests , Pyrroles/biosynthesis , Pyrroles/pharmacology , Staphylococcus/drug effects , Streptomyces/growth & development , Streptomyces/metabolism
4.
J Antibiot (Tokyo)
; 21(9): 525-31, 1968 Sep.
Article
in English
| MEDLINE
| ID: mdl-4388267
Subject(s)
Actinomycetales/metabolism , Anti-Bacterial Agents/analysis , Enterobacteriaceae/drug effects , Pneumococcal Infections/drug therapy , Staphylococcal Infections/drug therapy , Streptococcal Infections/drug therapy , Animals , Anti-Bacterial Agents/toxicity , Chromatography, Paper , Drug Resistance, Microbial , Mice , Spectrum Analysis , Staphylococcus/drug effects , Streptococcus/drug effects , Streptococcus pneumoniae/drug effects
5.
J Antibiot (Tokyo)
; 20(6): 329-33, 1967 Nov.
Article
in English
| MEDLINE
| ID: mdl-5631366
Subject(s)
Alkenes/analysis , Antifungal Agents/analysis , Streptomyces/analysis , Alkenes/pharmacology , Antifungal Agents/pharmacology , Bacteria/drug effects , Chemical Phenomena , Chemistry , Chromatography, Paper , Fermentation , Infrared Rays , Magnetic Resonance Spectroscopy , Mitosporic Fungi/drug effects , Spectrum Analysis , Streptomyces/metabolism , Ultraviolet Rays , Yeasts/drug effects
6.
Farmaco Sci
; 21(6): 450-63, 1966 Jun.
Article
in Italian
| MEDLINE
| ID: mdl-4957638
7.
Farmaco Sci
; 21(4): 269-77, 1966 Apr.
Article
in English
| MEDLINE
| ID: mdl-5935557