ABSTRACT
Atopic dermatitis (AD) is a common inflammatory skin disease that occurs most frequently in children. The disease is characterized as chronic, but only 20% of children suffer from severe AD, while the other 80% reach a long-term remission by the age of 8. The aim of the research was the analysis of modern sources of domestic and foreign literature, highlighting the features of the course of severe forms of AD. Results. The multifactorial nature of AD pathogenesis, based on the complex interaction of genetic factors, the immune system, the skin microbiome and environmental factors, causes certain difficulties for the physician, both in the diagnosis and therapy selection, and in predicting the course of the disease. Each patient has his own individual combination of clinical symptoms, medical history and aggravating factors that should be considered as predictors of the severity of the disease. Conclusion. Particular attention should be paid to patients with an early onset of AD, increased transepidermal water loss, with extensive skin lesions at the onset of the disease and under dynamic observation, with concomitant food allergies and/or bronchial asthma.
Subject(s)
Asthma , Dermatitis, Atopic , Food Hypersensitivity , Child , Humans , Risk FactorsABSTRACT
Trophic ulcers are complications of chronic venous insufficiency in 15-18% of cases and appear in 1-2% of able- bodied population. The frequency increases with age up to 4-5% among the patients aged over 65, and radical removalof the disease can be achieved only in one tenth of the patients. With that, even healed trophic ulcers recur frequently: after surgery in 4,8-31,6% of cases (according to various authors), after conservative treatment in 15-100% of cases. Main treatment modalities for trophic ulcers are medical and surgical. Recent researches necessitate including physical therapy methods into the treatment complex, as combined techniques that enable to improve results of various treatment variants.
Subject(s)
Leg Ulcer , Lower Extremity/blood supply , Venous Insufficiency , Chronic Disease , Disease Management , Humans , Leg Ulcer/etiology , Leg Ulcer/therapy , Venous Insufficiency/complications , Venous Insufficiency/diagnosisSubject(s)
Anti-Bacterial Agents/therapeutic use , Regeneration/drug effects , Surgical Tape , Wound Healing/drug effects , Wound Infection , Acute-Phase Reaction/etiology , Acute-Phase Reaction/physiopathology , Acute-Phase Reaction/therapy , Bacterial Infections/complications , Bacterial Infections/microbiology , Bacterial Infections/physiopathology , Bacterial Infections/therapy , Biocompatible Materials/therapeutic use , Debridement , Drainage , Drug Resistance, Multiple, Bacterial , Granulation Tissue/drug effects , Granulation Tissue/physiopathology , Humans , Suppuration/etiology , Suppuration/physiopathology , Suppuration/therapy , Wound Closure Techniques , Wound Infection/complications , Wound Infection/microbiology , Wound Infection/physiopathology , Wound Infection/therapyABSTRACT
Two comparable groups, 60 patients in each, were included in the study. Localization and area of the wounds, as well as basic treatment were equal in these groups. Patients of the main group received the additional photodynamic therapy with chlorine photosensibilizing agent. It led to the shortening of the wound clearing time and stimulation of the epithelisation together with fast decrease of bacterial load. Morphologic analysis showed faster inflammation decrease and granulation as well as lesser microcirculatory disorders in wounds treated with photodynamic therapy. Moreover, cicatrixes were more elastic and gentle in these patients.
