ABSTRACT
The paper is concerned with the results of the application of the sorption methods for the treatment of patients with rheumatoid arthritis and systemic lupus erythematosus. The authors show the advisability of the use of the above methods for different variants of the disease course, define the time of the treatment and complications common to the sorption methods of the treatment. The results of the treatment by hemoperfusion and enterosorption are compared with the results of the patients' treatment with immunodepressants. A study was made of the action of the sorption methods and immunodepressants on the blood content of the main autoantigens and autoantibodies capable of participation in the forming of the immune complexes. The concentration and the qualitative composition of the circulating immune complexes were studied in the course of the treatment.
Subject(s)
Arthritis, Rheumatoid/therapy , Hemoperfusion , Lupus Erythematosus, Systemic/therapy , DNA/analysis , Humans , Immunoglobulins/analysis , Immunosuppressive Agents/therapeutic use , RNA/analysisABSTRACT
Patients with rheumatoid arthritis and systemic lupus erythematosus associated with and without the clinical signs of the involvement of blood vessels were examined for the concentration of circulating immune complexes (CIC) and for the content of rheumatoid factor (RF), DNA and RNA as well as for the concentration of DNA, RNA and activity of acid nucleases in blood plasma. It was established that rheumatic vasculitis is coupled with a high concentration of CIC. In rheumatoid vasculitis, CIC contain a lot of rheumatoid factors which become far more activated after acidic dissociation of CIC. In patients with lupus vasculitis, CIC contain extremely much DNA. This is accompanied by dissociated interaction of DNA-DNase in blood plasma - activation of the enzyme is followed by the increased concentration of the substrate.
