Identifying ADHD-Related Abnormal Functional Connectivity with a Graph Convolutional Neural Network.

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that is characterized by inattention, hyperactivity, and impulsivity. The neural mechanisms underlying ADHD remain inadequately understood, and current approaches do not well link neural networks and attention networks within brain networks. Our objective is to investigate the neural mechanisms related to attention and explore neuroimaging biological tags that can be generalized within the attention networks. In this paper, we utilized resting-state functional magnetic resonance imaging data to examine the differential functional connectivity network between ADHD and typically developing individuals. We employed a graph convolutional neural network model to identify individuals with ADHD. After classification, we visualized brain regions with significant contributions to the classification results. Our results suggest that the frontal, temporal, parietal, and cerebellar regions are likely the primary areas of dysfunction in individuals with ADHD. We also explored the relationship between regions of interest and attention networks, as well as the connection between crucial nodes and the distribution of positively and negatively correlated connections. This analysis allowed us to pinpoint the most discriminative brain regions, including the right orbitofrontal gyrus, the left rectus gyrus and bilateral insula, the right inferior temporal gyrus and bilateral transverse temporal gyrus in the temporal region, and the lingual gyrus of the occipital lobe, multiple regions of the basal ganglia and the upper cerebellum. These regions are primarily involved in the attention executive control network and the attention orientation network. Dysfunction in the functional connectivity of these regions may contribute to the underlying causes of ADHD.

Decoding emotion with phase-amplitude fusion features of EEG functional connectivity network.

Decoding emotional neural representations from the electroencephalographic (EEG)-based functional connectivity network (FCN) is of great scientific importance for uncovering emotional cognition mechanisms and developing harmonious human-computer interactions. However, existing methods mainly rely on phase-based FCN measures (e.g., phase locking value [PLV]) to capture dynamic interactions between brain oscillations in emotional states, which fail to reflect the energy fluctuation of cortical oscillations over time. In this study, we initially examined the efficacy of amplitude-based functional networks (e.g., amplitude envelope correlation [AEC]) in representing emotional states. Subsequently, we proposed an efficient phase-amplitude fusion framework (PAF) to fuse PLV and AEC and used common spatial pattern (CSP) to extract fused spatial topological features from PAF for multi-class emotion recognition. We conducted extensive experiments on the DEAP and MAHNOB-HCI datasets. The results showed that: (1) AEC-derived discriminative spatial network topological features possess the ability to characterize emotional states, and the differential network patterns of AEC reflect dynamic interactions in brain regions associated with emotional cognition. (2) The proposed fusion features outperformed other state-of-the-art methods in terms of classification accuracy for both datasets. Moreover, the spatial filter learned from PAF is separable and interpretable, enabling a description of affective activation patterns from both phase and amplitude perspectives.

Top-down modulation of DLPFC in visual search: a study based on fMRI and TMS.

Effective visual search is essential for daily life, and attention orientation as well as inhibition of return play a significant role in visual search. Researches have established the involvement of dorsolateral prefrontal cortex in cognitive control during selective attention. However, neural evidence regarding dorsolateral prefrontal cortex modulates inhibition of return in visual search is still insufficient. In this study, we employed event-related functional magnetic resonance imaging and dynamic causal modeling to develop modulation models for two types of visual search tasks. In the region of interest analyses, we found that the right dorsolateral prefrontal cortex and temporoparietal junction were selectively activated in the main effect of search type. Dynamic causal modeling results indicated that temporoparietal junction received sensory inputs and only dorsolateral prefrontal cortex →temporoparietal junction connection was modulated in serial search. Such neural modulation presents a significant positive correlation with behavioral reaction time. Furthermore, theta burst stimulation via transcranial magnetic stimulation was utilized to modulate the dorsolateral prefrontal cortex region, resulting in the disappearance of the inhibition of return effect during serial search after receiving continuous theta burst stimulation. Our findings provide a new line of causal evidence that the top-down modulation by dorsolateral prefrontal cortex influences the inhibition of return effect during serial search possibly through the retention of inhibitory tagging via working memory storage.

Image Super-Resolution via Dual-Level Recurrent Residual Networks.

Recently, the feedforward architecture of a super-resolution network based on deep learning was proposed to learn the representation of a low-resolution (LR) input and the non-linear mapping from these inputs to a high-resolution (HR) output, but this method cannot completely solve the interdependence between LR and HR images. In this paper, we retain the feedforward architecture and introduce residuals to a dual-level; therefore, we propose the dual-level recurrent residual network (DLRRN) to generate an HR image with rich details and satisfactory vision. Compared with feedforward networks that operate at a fixed spatial resolution, the dual-level recurrent residual block (DLRRB) in DLRRN utilizes both LR and HR space information. The circular signals in DLRRB enhance spatial details by the mutual guidance between two directions (LR to HR and HR to LR). Specifically, the LR information of the current layer is generated by the HR and LR information of the previous layer. Then, the HR information of the previous layer and LR information of the current layer jointly generate the HR information of the current layer, and so on. The proposed DLRRN has a strong ability for early reconstruction and can gradually restore the final high-resolution image. An extensive quantitative and qualitative evaluation of the benchmark dataset was carried out, and the experimental results proved that our network achieved good results in terms of network parameters, visual effects and objective performance metrics.

Efficient Image Super-Resolution via Self-Calibrated Feature Fuse.

Recently, many super-resolution reconstruction (SR) feedforward networks based on deep learning have been proposed. These networks enable the reconstructed images to achieve convincing results. However, due to a large amount of computation and parameters, SR technology is greatly limited in devices with limited computing power. To trade-off the network performance and network parameters. In this paper, we propose the efficient image super-resolution network via Self-Calibrated Feature Fuse, named SCFFN, by constructing the self-calibrated feature fuse block (SCFFB). Specifically, to recover the high-frequency detail information of the image as much as possible, we propose SCFFB by self-transformation and self-fusion of features. In addition, to accelerate the network training while reducing the computational complexity of the network, we employ an attention mechanism to elaborate the reconstruction part of the network, called U-SCA. Compared with the existing transposed convolution, it can greatly reduce the computation burden of the network without reducing the reconstruction effect. We have conducted full quantitative and qualitative experiments on public datasets, and the experimental results show that the network achieves comparable performance to other networks, while we only need fewer parameters and computational resources.