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Australas J Dermatol ; 56(3): 175-9, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25179179

ABSTRACT

BACKGROUND/OBJECTIVES: Susceptibility to and clinical presentation of basal cell carcinoma (BCC) differ in Asian and Caucasian populations. This study aims to evaluate the epidemiological and clinicopathological characteristics of BCC in a multiracial Singaporean population, with a secondary comparative analysis between Chinese and Caucasian patients. METHODS: We prospectively studied patients with newly diagnosed, histologically confirmed BCC at the National Skin Centre, Singapore from 2004 to 2008. RESULTS: In total, 274 BCC from 260 patients were studied, with 19 patients having two or more tumours. Their mean age was 67.5 years and 54% were male. Chinese comprised 80% and Caucasians 14%. The Chinese were 1.8-fold as likely as Caucasians to be older than 60 years, and experienced itch thrice more frequently. Caucasians developed multiple BCC threefold and truncal or upper limb BCC 2.9-fold more frequently than the Chinese. In terms of tumour subtype, morphoeic BCC was 2.7-fold more common in Caucasians. Pigmented BCC occurred 2.7-fold more often in the Chinese, most frequently on the head and neck of elderly Chinese. CONCLUSIONS: Compared to the Chinese, BCC occurred more often in younger Caucasians, with a predilection for the trunk and upper limb, suggesting a greater role for recreational sun exposure as a risk factor. Pigmented BCC more commonly occurred on the head and neck of elderly Chinese and may be reflective of cumulative sun exposure as a risk factor. Aggressive morphoeic BCC was more common in Caucasians than in Singaporean Chinese patients.


Subject(s)
Carcinoma, Basal Cell/ethnology , Neoplasms, Multiple Primary/ethnology , Singapore/epidemiology , Skin Neoplasms/ethnology , Adult , Aged , Aged, 80 and over , Carcinoma, Basal Cell/pathology , China/ethnology , Female , Head , Humans , Hyperpigmentation/ethnology , Male , Middle Aged , Neck , Prospective Studies , Pruritus/ethnology , Skin Neoplasms/pathology , Torso , Upper Extremity , White People/ethnology
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