ABSTRACT
The cells of the various organ systems in humans are subject to mechanical forces to which they must respond. Here the authors review what is known of the ways in which the cells of animals, ranging from the prokaryotic to humans, sense and transduce mechanical forces to respond to such stimuli. In what way this pertains to the eye, especially with respect to axial myopia and the pressure related disease of glaucoma, is then surveyed.
Subject(s)
Mechanotransduction, Cellular/physiology , Ocular Physiological Phenomena , Cytoskeleton/physiology , Extracellular Matrix/physiology , Glaucoma/physiopathology , Humans , Ion Channel Gating/physiology , Myopia/physiopathology , PressureABSTRACT
AIM: To characterise measurement variability in scanning laser tomography of the optic nerve head. METHODS: 21 normal and 21 glaucoma subjects underwent same and separate day test-retest Heidelberg retina tomograph imaging by the same and different operators. RESULTS: Rim area was most reproducible among parameters. Its variability tended to be highest temporally and increased (p<0.05) with testing involving different operators and visits. Nature of regional variability differed between glaucoma and normal eyes and between standard and 320 micro m reference planes. CONCLUSIONS: Rim area is reproducible and potentially useful as a marker of progression. Pattern of variability and the influence of different reference planes, disease, operators, and visits should be considered when evaluating progression.
