Perspectives of Canadian and American Cat Owners on Provision of Uncontrolled Outdoor Access for Owned Domestic Cats.

While uncontrolled outdoor access can increase opportunities for cat physical and mental stimulation, it can also increase risks of injury and illness, and result in predation of wild birds and small animals. In Canada and the United States, it is often recommended to keep cats indoors, but many owners still provide some level of outdoor access. The objectives of this study were to use a cross-sectional survey to explore the attitudes and practices of cat owners in Canada and the United States toward outdoor access and to identify factors that influence the provision of uncontrolled outdoor access. A convenience sample of cat owners (N = 7,838) were recruited to complete an online survey, and a mixed logistic regression model was used to examine associations between cat and owner-related factors, and uncontrolled outdoor access for cats, with province/state included as a random effect. In total, 57% of owners kept their cats indoors, and 43% provided some form of outdoor access, with 21% of total owners providing uncontrolled outdoor access. Provision of uncontrolled outdoor access was associated with factors related to cat characteristics (e.g., sex, breed, presence of health, and behavioral issues), the home environment (e.g., living with other pets, types of enrichment provided), owner perspectives on outdoor access (e.g., level of agreement with potential benefits and consequence of outdoor access), and owner demographics (e.g., gender, education, area of residence). For cats with uncontrolled outdoor access, few owners reported their cats having a collar or a microchip, suggesting a need to increase education about precautionary measures to protect the welfare of outdoor cats. Results reveal how owners are caring for their cats in terms of providing outdoor access and generate hypotheses for future research to examine the influence of the owner-pet bond and educational programs on owner practices around providing outdoor access.

Androgens and Their Role in Regulating Sex Differences in the Hypothalamic/Pituitary/Adrenal Axis Stress Response and Stress-Related Behaviors.

Androgens play a pivotal role during development. These gonadal hormones and their receptors exert organizational actions that shape brain morphology in regions controlling the stress regulatory systems in a male-specific manner. Specifically, androgens drive sex differences in the hypothalamic/pituitary/adrenal (HPA) axis and corresponding hypothalamic neuropeptides. While studies have examined the role of estradiol and its receptors in sex differences in the HPA axis and associated behaviors, the role of androgens remains far less studied. Androgens are generally thought to modulate the HPA axis through the activation of androgen receptors (ARs). They can also impact the HPA axis through reduction to estrogenic metabolites that can bind estrogen receptors in the brain and periphery. Such regulation of the HPA axis stress response by androgens can often result in sex-biased risk factors for stress-related disorders, such as anxiety and depression. This review focuses on the biosynthesis pathways and molecular actions of androgens and their nuclear receptors. The impact of androgens on hypothalamic neuropeptide systems (corticotropin-releasing hormone, arginine vasopressin, oxytocin, dopamine, and serotonin) that control the stress response and stress-related disorders is discussed. Finally, this review discusses potential therapeutics involving androgens (androgen replacement therapies, selective AR modulator therapies) and ongoing clinical trials.

Social isolation alters hypothalamic pituitary adrenal axis activity after chronic variable stress in male C57BL/6 mice.

The chronic variable stress (CVS) paradigm is frequently used to model the changes in hypothalamic pituitary adrenal (HPA) axis function characteristic of many stress-related diseases. However, male C57BL/6 mice are typically resistant to CVS's effects, making it difficult to determine how chronic stress exposure may alter acute HPA function and regulation in these mice. As social support in rodents can profoundly influence physiological and behavioral processes, including the HPA axis, we sought to characterize the effects of CVS exposure on basal and acute stress-induced HPA axis function in pair- and single-housed adult male mice. Despite all subjects exhibiting decreased body weight gain after six weeks of CVS, the corticosterone response to a novel, acute restraint stressor was enhanced by CVS exclusively in single-housed males. CVS also significantly increased arginine vasopressin (AVP) mRNA in the hypothalamic paraventricular nucleus (PVN) in single-housed males only. Moreover, in single-, but not pair-housed mice, CVS attenuated decreases in circulating OT found following acute restraint. Only the effect of CVS to elevate PVN corticotropin releasing hormone (CRH) mRNA levels after an acute stressor was restricted to pair-housed mice. Collectively, our findings suggest that social isolation reveals effects of CVS on the HPA axis in male C57BL/6 mice.

Uncontrolled Outdoor Access for Cats: An Assessment of Risks and Benefits.

Uncontrolled outdoor access is associated with a number of welfare concerns for companion cats, including increased risks of disease and parasites, injury or death due to traffic, predation or ingestion of toxic substances, and getting permanently separated from their owner. In addition, cats pose a threat to local wildlife due to predatory behaviors, and can sometimes be a nuisance to human neighbors. Despite these concerns, recent estimates suggest that many owners are still providing their cats with uncontrolled outdoor access, likely because it also offers welfare benefits by allowing cats to perform natural behaviors, such as hunting, exploring, and climbing. While some have suggested that outdoor access is necessary to meet cats' behavioral needs and to prevent related behavioral problems, others have recommended various environmental enrichment strategies that can be developed to meet these needs within an indoor environment or through supervised and controlled outdoor access. This review examines the welfare issues and benefits associated with outdoor access for cats, as well as what is currently known about peoples' practices, knowledge, and attitudes about the provision of outdoor access for cats.