Folate-mediated magnetic and pH/GSH dual-responsive metal-polymer-coordinated nanocomplexes for joint chemo/chemodynamic anti-breast cancer therapy.

It is of great significance to develop a drug carrier that effectively targets chemotherapeutic drugs to the tumor site, improves therapeutic efficacy and reduces side effects associated with high-dose medicines. In the present study, an intelligent drug carrier system, FA-ß-CD/DOX@Cu2+@GA@Fe3O4, was synthesized by skillfully introducing metal ions as a bridge base. The performance of the prepared FA-ß-CD@Cu2+@GA@Fe3O4 metal-polymer-coordinated nanocomplexes were determined by UV-visible spectroscopy, NMR, FT-IR, XPS, VSM, DLS, and TEM analysis. The data showed that these nanocomplexes had good pH/GSH-responsive drug release behavior, and enabled enhanced magnetic and folic acid-mediated tumor cell targeting. Moreover, the toxicity effects of the FA-ß-CD/DOX@Cu2+@GA@Fe3O4 on 3T3 cells and 4T1 cells were measured by the MTT method, and it was found that it displayed low cytotoxicity against 3T3 cells and had a stronger effect on killing 4T1 cells than DOX alone. The results also showed that the Cu2+-based coordination polymers had a significant ability to deplete GSH and generate ROS. It could be concluded that the introduction of Cu2+ not only facilitated the assembly of nanocomplexes, but also successfully enhanced the anti-tumor effect, making FA-ß-CD@Cu2+@GA@Fe3O4 a potential nanoplatform for effectively mediating combined chemotherapy and chemokinetic therapy for tumors. All these characteristics verified the great potential of FA-ß-CD/DOX@Cu2+@GA@Fe3O4 in multipurpose smart drug delivery systems, accelerating the application range of metal-polymer-coordinated nanocomplexes in biomedical fields.

An intelligent drug carrier system FA-ß-CD/DOX@Cu²⁺@GA@Fe₃O₄ was synthesized by skillfully introducing metal ions as bridge base.Magnetic and receptor-targeting delivery of doxorubicin.It can induce the specific release of therapeutic agents through pH/GSH stimulation.Achieving an efficient tumor-specific chemotherapy/CDT therapy.

Biomonitoring human urinary levels of 26 metal elements in multi-race coexistence region of Xinjiang, China.

The human biological monitoring of metals (metalloids) is of importance, which concentrations could indicate a wide range of health related information. Reference values (RVs) of metals (metalloids) in specific matix of populations are critically required when performing a statistical evaluation accurately. Recent studies show that RVs of metals (metalloids) are influenced by many multiple factors, including lifestyle, diet, dissimilar environment, location, as well as race. However, it is virtually absent across many nations/regions, especially multi-race coexistence regions. The aim of the work was to establish RVs of metals (metalloids) in urine of adult in Xinjiang, China. Totally 178 urine samples from healthy volunteers were collected and analyzed by inductively coupled plasma mass spectrometer or optical emission spectrometer (ICP-MS/OES). RVs of 26 metals (metalloids) in urine for adult of Xinjiang, China were then established. Effects of race, gender and age on RVs were investigated using partial least squares discriminant analysis and student T-test. The result demonstrated that above factors showed mild influence for the establishment of RVs. The RVs derived from total 178 urine adult samples (Han and Uygur half of each) can be applied for different race, gender and age periods. Moreover, it was observed that three metals (metalloids), As, Sc and Ba significantly varied between some subgroups. The established RVs will be valuable for future health or environmental evaluation, and can serve as a theoretical reference for RVs establishment in multi-race coexistence region.

Analogue of electromagnetically induced absorption with double absorption windows in a plasmonic system.

We report the observation of an analog of double electromagnetically induced absorption (EIA) in a plasmonic system consisting of two disk resonators side-coupled to a discrete metal-insulator-metal (MIM) waveguide. The finite-difference time-domain (FDTD) simulation calculations show that two absorption windows are obtained and can be easily tuned by adjusting the parameters of the two resonance cavities. The consistence between the coupled-model theory and FDTD simulation results verify the feasibility of the proposed system. Since the scheme is easy to be fabricated, our proposed configuration may thus be applied to narrow-band filtering, absorptive switching, and absorber applications.