ABSTRACT
[Purpose] Foot arches are evaluated using radiographic morphometry and body surface somatometry. While several studies have examined the correlations between these methods and the medial longitudinal arch, very few studies have investigated the same for transverse arches. In this study, we analyzed the correlation between radiographic morphometry and body surface somatometry at medial longitudinal and transverse arches. [Participants and Methods] Fifty healthy adults were included in the study. Six medial longitudinal and three transverse arch evaluation methods were evaluated for the correlation, including the foot posture index. [Results] A correlation was found between the evaluation methods for the medial longitudinal arch, except the lateral talocalcaneal angle; however, no correlation was found between the navicular-metatarsal angle and transverse arch-length ratio in transverse arch evaluation. Additionally, there was no correlation between the evaluation methods for the medial longitudinal and transverse arches. The foot posture index was particularly correlated with radiographic medial longitudinal arch evaluation methods. [Conclusion] During evaluation with radiographic morphometry, it is difficult to set bone markers and differences in tarsal bone arrangement affect the relationship between them; in body surface somatometry, there were differences in measurement at sites with excessive soft tissue. Elucidating the cause for the lack of correlation between the medial longitudinal and transverse arches requires further investigation.
ABSTRACT
There have been some reports on the efficacy and tolerability of itraconazole (ITCZ) as prophylaxis for fungal infection after HSCT, and guidelines recommend itraconazole as a standard drug for prophylaxis of fungal infection in HSCT patients. However, it is not uncommon for patients undergoing HSCT to develop anorexia and taste disturbance. There are some cases where the bitter taste of ITCZ oral solution leads to interruption of administration because the patient refuses to take this medicine. Therefore, we investigated the clinical utility and influence on continuing treatment adherence by jellification of ITCZ. Compared with ITCZ oral solution, jellified ITCZ was extremely easy for most patients to take, and it was suggested that jellified ITCZ can make it easier for patients to continue treatment if they have difficulty with administration because of the bitter taste of ITCZ oral solution. Furthermore, it was confirmed that the plasma concentration of ITCZ was suitable for prophylaxis even with jellified ITCZ. This also suggested that the efficacy of ITCZ would be maintained by using jellified formation. For long-term antifungal therapy in patients with a high risk of fungal infection such as those having HSCT, it is very important for successful prophylaxis to maintain good adherence.
