Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Future Microbiol ; 15: 1439-1452, 2020 10.
Article in English | MEDLINE | ID: mdl-33156698

ABSTRACT

Aim: This work aimed to develop a membrane based on voriconazole (VCZ)-loaded natural rubber latex (NRL) for treating infected ulcers with Candida spp. and study their interaction, drug release, antifungal activity against Candida parapsilosis and biological characterization. Materials & methods: VCZ-loaded NRL membrane was produced by casting method. Results: Infrared spectrum showed that the incorporation of VCZ into the NRL membrane maintained its characteristics. Its mechanical properties were considered suitable for dermal application. The VCZ was able to release from NRL membrane, maintaining its antifungal activity against C. parapsilosis, besides did not present hemolytic effects. Conclusion: The VCZ-NRL membrane showed good results in mechanical, antifungal and biological assays, representing an interesting alternative to treatment of infected wound with Candida spp.


Subject(s)
Antifungal Agents/pharmacology , Bandages/microbiology , Candida/drug effects , Latex/chemistry , Skin Ulcer/microbiology , Voriconazole/pharmacology , Antifungal Agents/chemistry , Biomechanical Phenomena , Candida/growth & development , Humans , Microbial Sensitivity Tests , Skin Ulcer/drug therapy , Voriconazole/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...