1.
J Clin Microbiol
; 48(5): 1983-4, 2010 May.
Article
in English
| MEDLINE
| ID: mdl-20220172
Subject(s)
Antiviral Agents/pharmacology , Drug Resistance, Viral , Influenza A Virus, H1N1 Subtype/drug effects , Oseltamivir/pharmacology , Amino Acid Substitution/genetics , Humans , Influenza A Virus, H1N1 Subtype/genetics , Influenza, Human/virology , Microbial Sensitivity Tests/methods , Molecular Sequence Data , Mutation, Missense , Neuraminidase/genetics , RNA, Viral/genetics , Sequence Analysis, DNA , Viral Proteins/genetics
2.
Jpn J Infect Dis
; 62(1): 78-80, 2009 Jan.
Article
in English
| MEDLINE
| ID: mdl-19168969
Subject(s)
Influenza A Virus, H3N2 Subtype/genetics , Influenza A Virus, H3N2 Subtype/isolation & purification , Influenza, Human/virology , Aviation , Genes , Hemagglutination Inhibition Tests , Humans , Influenza, Human/epidemiology , Molecular Epidemiology , Phylogeny , Sequence Analysis, DNA , Travel
3.
Jpn J Infect Dis
; 60(5): 328-9, 2007 Sep.
Article
in English
| MEDLINE
| ID: mdl-17881883
4.
Jpn J Infect Dis
; 60(4): 202-4, 2007 Jul.
Article
in English
| MEDLINE
| ID: mdl-17642534
ABSTRACT
Using the newly designed mismatch amplification mutation assay (MAMA) PCR, we demonstrated the high frequency of amantadine-resistant influenza A (H3N2) viruses isolated during the 2005-2006 season by detecting the mutation at amino acid position 31 of the M2 protein (S31N). Further, phylogenetic analyses of the HA1 sequences of the S31N viruses revealed that they comprised a clonal lineage that would result in the common characteristic amino acid changes at positions 193 (Ser to Phe) and 225 (Asp to Asn) of the HA protein. We also demonstrated that the S31N/S193F/D225N viruses had already emerged in Aichi Prefecture by the end of the previous 2004-2005 season.
