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1.
Cureus ; 15(2): e35452, 2023 Feb.
Article in English | MEDLINE | ID: mdl-36851945

ABSTRACT

Newborns with untreated single ventricles develop pulmonary vascular diseases early in their lives. At that age, during the first eight weeks after birth, clinicians perform pulmonary artery (PA) banding to reduce the blood flow to the lung, decreasing the likelihood of future high vascular resistance or pressure. PA banding is also considered an initial stage in the process of single ventricle palliation procedures. We report a case of a 16-month-old toddler (7 kg) with room air saturation of 82%, diagnosed with tricuspid valve atresia, large atrial and ventricular septal defect, and hypoplastic right ventricle with severe pulmonary arterial hypertension. The baby underwent a successful surgical procedure of PA banding and was discharged after 13 days of hospital stay with a room air saturation of 89%. This case highlighted the benefit of PA banding beyond the stipulated period.

3.
Indian Pediatr ; 59(9): 683-687, 2022 09 15.
Article in English | MEDLINE | ID: mdl-35642923

ABSTRACT

BACKGROUND: There is limited literature in children on efficacy of different routes of vitamin B12 administration for vitamin B12 deficiency macrocytic-megaloblastic anemia. OBJECTIVE: To compare parenteral with oral vitamin B12 therapy in children with macrocytic-megaloblastic anemia. STUDY DESIGN: Single-center, open-label randomized controlled trial. PARTICIPANT: 80 children aged 2 month-18 year with clinical and laboratory features of nutritional macrocytic anemia. INTERVENTION: All children received an initial single parenteral dose of 1000 µg vitamin B12 followed by randomization to either parenteral or oral vitamin B12 for subsequent doses. Group A was given 1000 µg intramuscular (IM) vitamin B12 (3 doses on alternate days for those aged <10 year, five doses for age >10 year), followed by monthly 1000 µg IM for the subsequent two doses. Group B was given daily oral vitamin B12 1500 µg (500 µg in <2 years age) for three months. Folic acid and iron supple-mentation, and relevant dietary advice were given to both groups in a similar fashion. OUTCOME: Improvement in serum vitamin B12 levels and total hemoglobin was compared three months post-treatment. RESULT: The median(IQR) increase in serum vitamin B12 level was significantly higher in group A [600 (389,775) vs 399 (313, 606) pg/mL; P= 0.016]. The median (IQR) rise of hemoglobin was also more in group A [2.7 (0.4,4.6) vs 0.5 (-0.1,1.2) g/dL; P=0.001]. CONCLUSION: Increase in serum vitamin B12 levels and hemoglobin was better in children with nutritional macrocytic anemia receiving parenteral as compared to oral vitamin B12.


Subject(s)
Anemia, Macrocytic , Anemia, Megaloblastic , Vitamin B 12 Deficiency , Anemia, Macrocytic/drug therapy , Anemia, Megaloblastic/drug therapy , Child , Folic Acid/therapeutic use , Hemoglobins/analysis , Hemoglobins/therapeutic use , Humans , Vitamin B 12/therapeutic use , Vitamin B 12 Deficiency/drug therapy
4.
Cureus ; 13(4): e14407, 2021 Apr 10.
Article in English | MEDLINE | ID: mdl-33987057

ABSTRACT

Glutaric aciduria type II (GA II) also known as multiple acyl-CoA dehydrogenase deficiency is an inborn metabolic disorder belonging to the family of organic acidurias. It is a disorder that interferes with the body's ability to break down proteins and fats to produce energy. Tandem mass spectrometry (TMS) acts as a screening tool, while the diagnosis of GA-II with ketosis is confirmed by a combination of tests like organic acids, quantitative random urine, and a full urine panel. Early diagnosis, compliance to specialized diet, affordability, and regular follow-ups are required to tackle this potentially life-threatening condition. Herein, we report a case of glutaric aciduria type-II with ketosis in a 4.5 months old male infant who was managed with a low-protein diet, which was free of tryptophan, lysine, and other specific dietary supplements.

5.
J Family Med Prim Care ; 10(11): 4307-4310, 2021 Nov.
Article in English | MEDLINE | ID: mdl-35136808

ABSTRACT

Central nervous system (CNS) tuberculosis is a life-threatening infection and has a wide variety of presentations in children. We report a case of intracranial tuberculomas with tuberculous cervical lymphadenitis in an adolescent girl with a recurrent transient ischemic attack (TIA) like unusual presentation managed with antitubercular therapy and anti-convulsant.

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