A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections.

New antibiotics should ideally exhibit activity against drug-resistant bacteria, delay the development of bacterial resistance to them and be suitable for local delivery at desired sites of infection. Here, we report the rational design, via molecular-docking simulations, of a library of 17 candidate antibiotics against bone infection by wild-type and mutated bacterial targets. We screened this library for activity against multidrug-resistant clinical isolates and identified an antibiotic that exhibits potent activity against resistant strains and the formation of biofilms, decreases the chances of bacterial resistance and is compatible with local delivery via a bone-cement matrix. The antibiotic-loaded bone cement exhibited greater efficacy than currently used antibiotic-loaded bone cements against staphylococcal bone infections in rats. Potent and locally delivered antibiotic-eluting polymers may help address antimicrobial resistance.

Simultaneous Hardening/Ductilizing Effects of Cryogenic Nanohybridization of Biopolyamides with Montmorillonites.

We prepared organic/inorganic bionanohybrid resins of polyamides containing pyrrolidone in the backbone derived from the salt monomers of an itaconic acid biomolecule with various nanofillers, montmorillonites (MMTs), by cryogenic nanohybridizations. The nanohybridizations with MMTs hardened and strengthened the polypyrrolidone bioplastic resins owing to a simple reinforcement of hard filler incorporation. On the other hand, the elongation at break of the resins is unexpectedly increased by the nanohybridization with MMT sodium salt (NaMMT) to enhance the strain energy density, which differed from those of the nanohybrids with other organically modified MMTs. From spectroscopic analyses, we discuss the mechanism of such ductilization effects by NaMMT, the catalytic effect of NaMMT on partially opening the pyrrolidone ring to make polymer backbones flexible and to form carboxyl side chains that are strongly interactive with NaMMT fillers.

Primary squamous cell carcinoma of the endometrium: a case report.

Squamous cell carcinoma of the endometrium is extremely rare female genital malignancy. Only 64 cases have been reported in the literature. A case of primary squamous cell carcinoma of endometrium in a 55-year old-woman is reported. Examination revealed pyometra and cervical stenosis. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology confirmed the diagnosis.