1.
Chem Commun (Camb)
; 52(58): 9093-6, 2016 Jul 12.
Article
in English
| MEDLINE
| ID: mdl-26940443
ABSTRACT
Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.
Subject(s)
Fluorescent Dyes/chemistry , Molecular Imaging , Superoxide Dismutase-1/analysis , Molecular Structure , Superoxide Dismutase-1/metabolism
2.
ACS Comb Sci
; 15(9): 452-7, 2013 Sep 09.
Article
in English
| MEDLINE
| ID: mdl-23941241
ABSTRACT
Elucidating how molecules bind to HSA is fundamental for predicting drug incompatibilities. Through combinatorial screening, we identified a novel fluorescent dye (BD140) with turn-on fluorescence emission and specific binding at HSA drug site 2. We further combined it with dansylamide to develop a fluorescent dye cocktail for high-throughput mapping of the interaction between therapeutics at HSA drug-binding sites.
