ABSTRACT
Two nucleotide changes in codon 77 (ACC â AAT) of HLA-DRB1*14:05:03 result in the allele, HLA-DRB1*14:127:01.
Subject(s)
Alleles , Exons , HLA-DRB1 Chains/genetics , Mutation , Tissue Donors , Amino Acid Substitution , Asian People , Base Sequence , Codon/chemistry , Genotype , HLA-DRB1 Chains/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
The novel HLA-B*40:229 allele shows one nucleotide difference from B*40:02:01 in exon 2 at nucleotide position 97 (C â T).
Subject(s)
Alleles , HLA-B40 Antigen/genetics , Point Mutation , Base Sequence , Bone Marrow Transplantation , China , Codon , Exons , Genotype , HLA-B40 Antigen/immunology , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence Alignment , Sequence Analysis, DNA , Tissue DonorsABSTRACT
The newly detected HLA-B*40:210 allele has two nucleotide changes in exon 2 compared to B*40:49 allele.
Subject(s)
Alleles , Amino Acid Substitution , HLA-B40 Antigen/genetics , Polymorphism, Single Nucleotide , Asian People , Base Sequence , Bone Marrow Transplantation , Codon , Exons , HLA-B40 Antigen/classification , HLA-B40 Antigen/immunology , Histocompatibility Testing , Humans , Molecular Sequence Data , Protein Isoforms/classification , Protein Isoforms/genetics , Protein Isoforms/immunology , Sequence Alignment , Tissue DonorsABSTRACT
HLA-A*11:125 allele differs from A*11:01:01 by one nucleotide substitution at nt 140 from T to C.
Subject(s)
Alleles , HLA-A Antigens/genetics , Point Mutation , Female , Humans , MaleABSTRACT
The novel HLA-A*02:06:13 allele shows one nucleotide difference from A*02:06:01 in exon 4 at nucleotide position 657 (TâC).
Subject(s)
Asian People , HLA-A2 Antigen/genetics , Histocompatibility Testing , Base Sequence , Bone Marrow Transplantation , Exons/genetics , Gene Frequency , Genotype , Humans , Molecular Sequence Data , Polymorphism, Single Nucleotide , Sequence Analysis, DNA , Tissue DonorsABSTRACT
HLA-B*40:211 allele differs from HLA-B*40:02:01 by an amino acid exchange at position 132, which has a missense mutation in exon 3 from Ser to Tyr.
Subject(s)
Alleles , HLA-B Antigens/genetics , Mutation, Missense , Asian People , Base Sequence , Bone Marrow Transplantation , Exons , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence Alignment , Sequence Analysis, DNA , Tissue DonorsABSTRACT
A novel HLA-DRB1 allele, DRB1*13:26:02, has been identified by sequence-based typing in a Chinese individual.
