ABSTRACT
In the practical application of quantum entanglement, entangled particles usually need to be distributed to many distant parties or stored in different quantum memories. In these processes, entangled particles unavoidably interact with their surrounding environments, respectively. We here systematically investigate the entanglement-decay laws of cat-like states under independent Pauli noises with unbalanced probability distribution of three kinds of errors. We show that the robustness of cat-like entangled states is not only related to the overall noise strength and error distribution parameters, but also to the basis of qubits. Moreover, we find that whether a multi-qubit state is more robust in the computational basis or transversal basis depends on the initial entanglement and number of qubits of the state as well as the overall noise strength and error distribution parameters of the environment. However, which qubit basis is conductive to enhancing the robustness of two-qubit states is only dependent on the error distribution parameters. These results imply that one could improve the intrinsic robustness of entangled states by simply transforming the qubit basis at the right moment. This robustness-improving method does not introduce extra particles and works in a deterministic manner.
ABSTRACT
The thiazolidine and imidazolidine heterocyclic scaffolds, i.e., the rhodanines, 2,4-thiazolidinediones, 2-thiohydantoins, and hydantoins have been the subject of debate on their suitability as starting points in drug discovery. This attention arose from the wide variety of biological activities exhibited by these scaffolds and their frequent occurrence as hits in screening campaigns. Studies have been conducted to evaluate their value in drug discovery in terms of their biological activity, chemical reactivity, aggregation-based promiscuity, and electronic properties. However, the metabolic profiles and toxicities have not been systematically assessed. In this study, a series of five-membered multiheterocyclic (FMMH) compounds were selected for a systematic evaluation of their metabolic profiles and toxicities on TAMH cells, a metabolically competent rodent liver cell line and HepG2 cells, a model of human hepatocytes. Our studies showed that generally the rhodanines are the most toxic, followed by the thiazolidinediones, thiohydantoins, and hydantoins. However, not all compounds within the family of heterocycles were toxic. In terms of metabolic stability, 5-substituted rhodanines and 5-benzylidene thiohydantoins were found to have short half-lives in the presence of human liver microsomes (t1/2 < 30 min) suggesting that the presence of the endocyclic sulfur and thiocarbonyl group or a combination of C5 benzylidene substituent and thiocarbonyl group in these heterocycles could be recognition motifs for P450 metabolism. However, the stability of these compounds could be improved by installing hydrophilic functional groups. Therefore, the toxicities and metabolic profiles of FMMH derivatives will ultimately depend on the overall chemical entity, and a blanket statement on the effect of the FMMH scaffold on toxicity or metabolic stability cannot and should not be made.
