ABSTRACT
Oral glucose tolerance test and determination of insulin, cholesterol, triglycerides, total bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase and cortisol in blood were performed on 57 Thai women who had used depot-medroxyprogesterone acetate (DMPA) for 5 years or more and 24 healthy non-DMPA users. Plasma insulin, alkaline phosphatase and morning cortisol levels were significantly higher in the DMPA users than in the non-users. There were no significant differences for other laboratory tests. The findings suggest some effects of DMPA on carbohydrate metabolism and liver function in long-term users.
Subject(s)
Medroxyprogesterone/analogs & derivatives , Adult , Alkaline Phosphatase/blood , Contraceptives, Oral, Synthetic/metabolism , Cross-Sectional Studies , Female , Glucose Tolerance Test , Humans , Hydrocortisone/blood , Insulin/blood , Medroxyprogesterone/blood , Medroxyprogesterone/metabolism , Medroxyprogesterone Acetate , Middle Aged , Pregnancy , Thailand , Time FactorsABSTRACT
PIP: A prospective study to determine the metabolic effects of norgestrel, a progestogen only contraceptive, was undertaken. 3 hour oral glucose tolerance test (OGTT) as well as measurements of plasma insulin during OGTT, serum cholesterol, and triglycerides were performed before and at 1 month, and 3, 6, 9, and 12 months after daily administration of 30 mcg norgestrel to 11 Thai women. There was no statistical significance observed in any of the glucose, insulin, and cholesterol levels. Triglycerides values were lowered but, except for the 6 month test, were not statistically significant. The data suggest that daily use of 30 mcg norgestrel for 1 year has a negligible effect on fasting total cholesterol and triglyceride levels as well as blood glucose and plasma insulin concentrations measured during the OGTT.^ieng
Subject(s)
Blood Glucose/analysis , Cholesterol/blood , Insulin/blood , Norgestrel/pharmacology , Triglycerides/blood , Adult , Carbohydrate Metabolism , Female , Humans , Lipid Metabolism , Prospective StudiesABSTRACT
Eight bilaterally oophorectomized women were given a depot injection of 200 mg DHEA-enanthate to study the effect on endocrine and lipid metabolism. A decrease in sex-hormone binding globulin (SHBG) and an increase in androstenedione was found 14 and 30 days after the injection. No changes could be detected in LH, FSH, oestrone, oestradiol or oestriol. Testosterone showed a tendency towards an increase. As compared to pre-treatment values, plasma lipids were unaltered after 30 days. A decrease in high density lipoproteins (HDL), cholesterol and in very low density lipoproteins (VLDL), free cholesterol, total cholesterol and phospholipids were seen in the lipid composition of the lipoproteins on day 30. These findings are in agreement with previous data reported after the administration of drugs with androgen-like effects. The relative fatty acid composition of plasma lecithin revealed only minor changes while the fatty acid composition of cholesterol esters indicated a decreased portion of essential fatty acids. These results suggest, in agreement with previous studies, an impaired endogenous cholesterol formation in the liver. The results from the analysis of the fatty acid composition of lecithin and cholesterol esters might indicate a decreased percentage of exogenous (dietary) cholesterol ester in plasma.
