ABSTRACT
1. The effectiveness of the inclusion product of piroxicam with beta-cyclodextrin was compared to that of free piroxicam on inflammatory reactions by using three experimental inflammatory models in rats. 2. The inclusion compound showed anti-inflammatory effects similar to those of simple piroxicam on granuloma tissue formation and arthritis induced by complete Freund adjuvant. 3. In carrageenin-induced pleurisy, the piroxicam beta-cyclodextrin reduced leukocyte mobilization more intensely than non-complexed piroxicam. 4. These results suggest that beta-cyclodextrin is a useful tool for improving the efficacy of piroxicam.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Cyclodextrins/pharmacology , Piroxicam/pharmacology , beta-Cyclodextrins , Animals , Arthritis, Experimental/drug therapy , Carrageenan , Freund's Adjuvant , Gossypium , Granuloma/chemically induced , Granuloma/drug therapy , Male , Pleurisy/chemically induced , Pleurisy/drug therapy , Rats , Rats, WistarABSTRACT
The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis. The compound was tested for in vivo anti-inflammatory and analgesic activities in rats. The inhibitory effect on carrageenin-induced paws inflammation and analgesic effect of copper flurbiprofen complex were similar to those of free flurbiprofen. However, the copper complex produced less gastric irritation than the parent drug.
