ABSTRACT
Familial Mediterranean fever (FMF) is an autoimmune disease inherited as an autosomal recessive trait and is characterized by recurrent attacks of fever and sterile polyserositis. This study examined electrocardiographic ventricular repolarization parameters (QT interval and QT dispersion) in 38 FMF patients and 35 healthy controls. The QT interval was measured manually from the onset of QRS to the end of the T wave (return to the TP baseline). QT dispersion was defined as the difference between the maximum and minimum QT values, and corrected QT was calculated according to the Bazett formula. There were no significant differences between FMF patients and healthy control subjects in any parameter of ventricular repolarization; hence QT dispersion was not affected by FMF. Electrocardiographic assessment of QT interval and QT dispersion are, therefore, of little value for the evaluation of cardiac impairment and risk of arrhythmia in FMF patients.
Subject(s)
Electrophysiological Phenomena , Familial Mediterranean Fever/physiopathology , Heart Ventricles/physiopathology , Adult , Cardiovascular Diseases/diagnosis , Cardiovascular Diseases/etiology , Case-Control Studies , Electrocardiography , Familial Mediterranean Fever/complications , Female , Humans , Male , Young AdultABSTRACT
This is a report of a patient who had documented coronary artery disease and was admitted with chest pain, nausea, vomiting and headache. She was immediately taken to coronary angiography and underwent percutaneous coronary intervention with stent implantation. After the operation, she was coincidentally diagnosed to have Carbon Monoxide (CO) poisoning. We discuss if percutaneous intervention (PCI) was an overtreatment and briefly review the mechanisms of the cardiovascular effects of CO toxicity which is an insidious pathology and diagnosed only if it is suspected.
Este es un reporte de una paciente con enfermedad de la arteria coronaria documentada, quien fuera ingresado con dolor de pecho, náuseas, vómitos y dolor de cabeza. A la paciente se le hizo inmediatamente una angiografía coronaria y se le realizó una intervención coronaria percutánea con implantación de stent. Después de la operación, se le diagnosticó por coincidencia envenenamiento por monóxido de carbono (CO). Analizamos si la intervención percutánea (IPC) fue un sobretratamiento y examinamos brevemente los mecanismos de los efectos cardiovasculares de la toxicidad por CO que puede ser insidiosa y diangosticada sólo si se tiene sospecha.
Subject(s)
Female , Humans , Middle Aged , Carbon Monoxide Poisoning/diagnosis , Coronary Artery Disease/diagnosis , Diagnostic Errors , Blood Gas Analysis , Carbon Monoxide Poisoning/complications , Chest Pain/etiology , Coronary Angiography , Coronary Artery Disease , Coronary Artery Disease/surgery , ElectrocardiographyABSTRACT
An increasing number of patients under 40 years of age are being hospitalized with the diagnosis of acute myocardial infarction. This is partly due to the increased prevalance of risk factors for atherosclerosis in the younger age group; especially increased incidence of impaired fasting glucose, high triglyceride, low high-density lipoprotein levels and increased waist to hip ratio. However, non-atherosclerotic coronary artery disease or hypercoagulability should also be investigated or at least suspected in the younger patients. The pathophysiology of different clinical conditions and disease states which cause acute coronary syndromes in the young patients are reviewed, and the diagnostic modalities and therapatic options for these conditions are briefly discussed by searching for "premature atherosclerosis", "hypercoagulable states", "risk factors for atherosclerosis in youth", "novel risk factors for atherosclerosis", "non-atherosclerotic coronary artery diseases" in PubMed.
Subject(s)
Coronary Artery Disease/epidemiology , Myocardial Infarction/epidemiology , Adult , Age Factors , Atherosclerosis/complications , Blood Coagulation Disorders/complications , Connective Tissue Diseases/complications , Coronary Artery Disease/complications , Female , Humans , Incidence , Lipid Metabolism/physiology , Male , Myocardial Infarction/diagnosis , Myocardial Infarction/etiology , Prevalence , Risk Factors , Substance-Related Disorders/complicationsABSTRACT
This is a report of a patient who had documented coronary artery disease and was admitted with chest pain, nausea, vomiting and headache. She was immediately taken to coronary angiography and underwent percutaneous coronary intervention with stent implantation. After the operation, she was coincidentally diagnosed to have Carbon Monoxide (CO) poisoning. We discuss if percutaneous intervention (PCI) was an overtreatment and briefly review the mechanisms of the cardiovascular effects of CO toxicity which is an insidious pathology and diagnosed only if it is suspected.
