[Stability of clinically used cytostatics (author's transl)]. / Stabilität klinisch gebräuchlicher Zytostatika

This paper concerns with the stability of aqueous solutions of clinically used cytostatics. The investigation was carried out with in vitro-activated cyclophosphamide from urine of patients, also with trenimon, vinblastine and methotrexate. The stability was tested by biological determination of tumor cell cultures, NBP-reaction and spectrophotometric investigations at different temperature of storage. The activated cyclophosphamide and the active metabolites from urine too are unstable in contrast to the active metabolites in lyophylisied urine. While vinblastine in our results are stable for ten days and more and methotrexate for fourteen days in the refrigerater in physiological solution, trenimon decomposed relative rapidly.