ABSTRACT
HBV DNA was measured in the sera of 69 patients with hepatitis B virus infections. Sixteen patients had acute hepatitis B, 24 had chronic active hepatitis (CAH), 6 had chronic persistent hepatitis (CPH), 5 had cirrhosis without CAH and 18 were asymptomatic HBsAg carriers. In patients with acute hepatitis B who recovered, HBV DNA was present in the serum transiently early in the illness. HBV DNA persisted in the serum in the two patients who developed chronic hepatitis. Sera of 23 of 24 patients with CAH were persistently positive for HBV DNA. There was no relationship between the quantity of HBV DNA in the serum and the histological intensity of activity. Thirteen of the 24 patients with CAH had histological evidence of cirrhosis in addition to CAH and HBV DNA was detected in the sera of all 13. The sera of 2 of 6 patients with CPH were positive for HBV DNA. In one it was positive only where there was clinical evidence of reactivation of HBV infection. The other patient subsequently developed CAH. Sera of 5 patients with established HBsAg positive cirrhosis but without evidence of CAH were negative for HBV DNA. Two of these patients had hepatocellular carcinoma. Sera of 18 asymptomatic anti-HBe positive carriers with normal ALT were negative for HBV DNA. HBeAg and HBV DNA were not always found in the serum together. In acute hepatitis 5 patients with HBV DNA in the serum were HBeAg positive, but in 6 patients the sera were HBeAg positive inthe absenceof HBV DNA.
Subject(s)
DNA, Viral/blood , Hepatitis B virus/isolation & purification , Hepatitis B/blood , Acute Disease , Adult , Female , Hepatitis B/microbiology , Hepatitis B virus/physiology , Hepatitis, Chronic/blood , Hepatitis, Chronic/microbiology , Humans , Liver Cirrhosis/blood , Liver Cirrhosis/microbiology , Male , Virus ReplicationABSTRACT
En este estudio analizamos los resultados preliminares obtenidos en 26 pacientes cirróticos, hemodinámicamente estables, que fueron sometidos a escleroterapia ambulatoria de várices esofágica. Todos los pacientes presentaban un episódio previo de hemorragia variceal. Once de ellos pertenecían a la clase A de la clasificación de Child, 10 a la clase B y 5 a la clase C. Se realizaron 103 sesiones de escleroterapia de hemorragia digestiva postescleroterapia que requieron internación (1,9%) del total de sesiones). Fiebre (2,9%), disfagia (6,8%), dolor precordial (14,6%) y una instancia de depresión respiratória por sedación fueron notados, pero se manejaron con medidas simples. Uno de 26 pacientes desarrolló estenosis esofágica. Estos resultados sugieren que este procedimiento puede realizarse en forma ambulatoria, en pacientes seleccionados, con un bajo riesgo de complicaciones serias
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Ambulatory Care , Esophageal and Gastric Varices/therapy , Retrospective Studies , Sclerosing Solutions/therapeutic useABSTRACT
En este estudio analizamos los resultados preliminares obtenidos en 26 pacientes cirróticos, hemodinámicamente estables, que fueron sometidos a escleroterapia ambulatoria de várices esofágica. Todos los pacientes presentaban un episódio previo de hemorragia variceal. Once de ellos pertenecían a la clase A de la clasificación de Child, 10 a la clase B y 5 a la clase C. Se realizaron 103 sesiones de escleroterapia de hemorragia digestiva postescleroterapia que requieron internación (1,9%) del total de sesiones). Fiebre (2,9%), disfagia (6,8%), dolor precordial (14,6%) y una instancia de depresión respiratória por sedación fueron notados, pero se manejaron con medidas simples. Uno de 26 pacientes desarrolló estenosis esofágica. Estos resultados sugieren que este procedimiento puede realizarse en forma ambulatoria, en pacientes seleccionados, con un bajo riesgo de complicaciones serias (AU)
Subject(s)
Adolescent , Adult , Middle Aged , Aged , Humans , Male , Female , Esophageal and Gastric Varices/therapy , Sclerosing Solutions/therapeutic use , Ambulatory Care , Retrospective StudiesABSTRACT
We performed endoscopic sclerotherapy of esophageal varices (ESEV) as an outpatient procedure in a private setting in patients with portal hypertension and a least one previous episode of variceal hemorrhage. Twenty-six stable cirrhotic patients (child's class A, 11 patients; class B, 10 patients; class C, 5 patients) underwent 103 outpatient sessions of ESEV. There were two episodes of post-sclerotherapy bleeding (1.9% of total sessions) requiring hospitalisation. Fever (2.9%), dysphagia (6.8%), chest pains (14.6%) and one episode (1%) of respiratory depression due to sedation were also noted, but were managed with simple measures. One of 26 patients developed esophageal stricture. These preliminary results suggest that ESEV can be performed as a relatively safe ambulatory procedure.
Subject(s)
Ambulatory Care , Esophageal and Gastric Varices/therapy , Sclerosing Solutions/therapeutic use , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Retrospective StudiesABSTRACT
We performed endoscopic sclerotherapy of esophageal varices (ESEV) as an outpatient procedure in a private setting in patients with portal hypertension and a least one previous episode of variceal hemorrhage. Twenty-six stable cirrhotic patients (childs class A, 11 patients; class B, 10 patients; class C, 5 patients) underwent 103 outpatient sessions of ESEV. There were two episodes of post-sclerotherapy bleeding (1.9
of total sessions) requiring hospitalisation. Fever (2.9
), dysphagia (6.8
), chest pains (14.6
) and one episode (1
) of respiratory depression due to sedation were also noted, but were managed with simple measures. One of 26 patients developed esophageal stricture. These preliminary results suggest that ESEV can be performed as a relatively safe ambulatory procedure.
