ABSTRACT
This study was performed to investigate the antioxidant mechanisms of polymorphonuclear leucocytes (PMN) in active stage of Behçet's Disease. PMN activities of myeloperoxidase (p < 0.02), superoxide dismutase (p < 0.001), catalase (p < 0.005), and glutathione peroxidase (p < 0.005) were significantly lower in the patients: the NADPH oxidase activity was significantly higher (p < 0.001) than those in controls. The plasma levels of ceruloplasmin (Cp), fibrinogen, and copper (Cu) were also significantly higher in the patients group (p < 0.001). Significant and positive correlations were found between the glutathione peroxidase and catalase activities (p < 0.001) and also between the plasma Cp and Cu levels (p < 0.001) in the patients group. However, no correlation was observed among the other enzyme activities. In the control group, a significantly positive correlation was present only between the plasma ceruloplasmin and Cu levels (p < 0.001). It was concluded that (impaired PMN functions) decreased enzyme activities in the antioxidant system and increased levels of oxygen free radicals may play a role in tissue damage in Behçet's disease.
Subject(s)
Behcet Syndrome/blood , Ceruloplasmin/metabolism , Copper/blood , Fibrinogen/metabolism , Neutrophils/enzymology , Oxidoreductases/metabolism , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Bipolar Disorder/drug therapy , Erythrocyte Count/drug effects , Hydrocortisone/blood , Leukocyte Count/drug effects , Lithium/adverse effects , Adult , Bipolar Disorder/blood , Bipolar Disorder/psychology , Female , Granulocytes/drug effects , Humans , Leukocytosis/blood , Leukocytosis/chemically induced , Lithium/pharmacokinetics , Lithium/therapeutic use , MaleSubject(s)
Anxiety Disorders/enzymology , Depressive Disorder/enzymology , Isoenzymes/blood , Monoamine Oxidase/blood , Adolescent , Adult , Age Factors , Anxiety Disorders/diagnosis , Anxiety Disorders/psychology , Depressive Disorder/diagnosis , Depressive Disorder/psychology , Female , Humans , Male , Middle Aged , Personality AssessmentABSTRACT
The levels of superoxide dismutase (SOD) and myeloperoxidase (MPO) in polymorphonuclear leukocytes (PMN), and serum ceruloplasmin activity and copper content, were measured in 60 patients with psoriasis and 33 healthy controls. There were no significant differences in the activity of MPO between the patients and the controls. However, SOD activity in PMN was significantly lower in the patients than in the controls. Serum ceruloplasmin activity and copper levels were significantly higher in the psoriatics than in the controls.
