ABSTRACT
INTRODUCTION: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. METHODS: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. RESULTS: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group (p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters (p > 0.05) in the patient group. All biomarkers were positively correlated with each other (p < 0.001). CONCLUSIONS: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.
Subject(s)
Asbestos/toxicity , Cell Adhesion Molecules/blood , Chitinase-3-Like Protein 1/blood , Indoleamine-Pyrrole 2,3,-Dioxygenase/blood , Mesothelioma, Malignant/chemically induced , Mesothelioma, Malignant/diagnosis , Neopterin/blood , Tenascin/blood , Adult , Biomarkers, Tumor/blood , Cross-Sectional Studies , Female , Humans , Male , Mesothelioma, Malignant/blood , Mesothelioma, Malignant/physiopathology , Middle Aged , Pleural Neoplasms/chemically induced , Pleural Neoplasms/diagnosis , Pleural Neoplasms/physiopathology , Prospective StudiesABSTRACT
BACKGROUND: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-γ) activation. These include viral and bacterial infections, auto immune diseases, metabolic diseases, psychiatric disorders, tissue and organ rejections, and different malignancies. The aim of this study was to evaluate the role of neopterin as a prognostic biomarker in type 2 diabetes, which is a metabolic disease with a high worldwide prevalence. METHODS: The study included a total of one hundred thirtynine individuals including one hundred and six patients admitted to a family medicine outpatient clinic and diagnosed with type 2 diabetes and thirty-three healthy volunteers. Serum neopterin concentrations were measured using the enzyme-linked immunosorbent assay. RESULTS: Serum neopterin levels significantly increased in type 2 diabetes patients, compared to the control group (p<0.001). CONCLUSIONS: Early diagnosis of diabetes and determination of the appropriate therapeutic options are of utmost importance, as diabetes is also associated with other systemic diseases. The risk of developing secondary diseases is high in untreated patients. Our study results suggest that serum neopterin may be a useful biomarker in patients with type 2 diabetes.
