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Clin Infect Dis ; 36(10): 1329-31, 2003 May 15.
Article in English | MEDLINE | ID: mdl-12746781

ABSTRACT

A prospective, multicenter, randomized study was conducted with human immunodeficiency virus (HIV)-infected patients who were successfully treated for acute cryptococcal meningitis, were receiving secondary prophylaxis, and were naive for antiretroviral therapy. Patients were randomized to continue or discontinue secondary prophylaxis when the CD4 cell count had increased to >100 cells/microL and an undetectable HIV RNA level had been sustained for 3 months. At a median of 48 weeks after randomization, there were no episodes of cryptococcal meningitis in either group.


Subject(s)
AIDS-Related Opportunistic Infections/prevention & control , Antibiotic Prophylaxis , HIV Infections/complications , Meningitis, Cryptococcal/prevention & control , Adult , Anti-HIV Agents/therapeutic use , Antiretroviral Therapy, Highly Active , CD4 Lymphocyte Count , Female , HIV , HIV Infections/drug therapy , Humans , Male , Prospective Studies , RNA, Viral/analysis
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