Atomic faulting induced exceptional cryogenic strain hardening in gradient cell-structured alloy.

Coarse-grained materials are widely accepted to display the highest strain hardening and the best tensile ductility. We experimentally report an attractive strain hardening rate throughout the deformation stage at 77 kelvin in a stable single-phase alloy with gradient dislocation cells that even surpasses its coarse-grained counterparts. Contrary to conventional understanding, the exceptional strain hardening arises from a distinctive dynamic structural refinement mechanism facilitated by the emission and motion of massive multiorientational tiny stacking faults (planar defects), which are fundamentally distinct from the traditional linear dislocation-mediated deformation. The dominance of atomic-scale planar deformation faulting in plastic deformation introduces a different approach for strengthening and hardening metallic materials, offering promising properties and potential applications.

Interaction between m6A methylation and noncoding RNA in glioma.

Glioma is considered to be the most common brain malignancy in the central nervous system. At present, the aetiology of glioma is not clear. Due to its rapidly growth and easily recurrence, the prognosis of patients with glioma is very poor. N6-methyladenosine (m6A) methylation is an internal reversible modification in most RNAs, including messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). Recent studies have shown that the m6A regulators are abnormal expressed, and are extensively involved in the progression of glioma by targeting ncRNAs. Moreover, as the most important epigenetic regulators, ncRNAs can also affect the function of m6A regulators in glioma. This review summarized the expression and function of certain common m6A regulators in glioma. Also, the current review sum up the mutual interactions between m6A regulators and ncRNAs in glioma.

Deformation Twinning Induced High Tensile Ductility of a Gradient Nanograined Cu-Based Alloy.

We investigated the tensile properties of gradient nanograined Cu and CuAl samples prepared by plastic deformation. Tensile tests showed that the gradient nanograined Cu-4.5Al sample exhibits a uniform elongation of ~22% without any cracks, while the uniform elongation of the gradient nanograined Cu sample is only ~18%. Numerous mechanical twinning retards the softening of the nanograins and accommodates a high tensile ductility in the gradient nanograined Cu-4.5Al sample. This work indicates that mechanical twinning is a potential deformation mechanism to achieve high tensile ductility of nanograined materials.

Plastic accommodation at homophase interfaces between nanotwinned and recrystallized grains in an austenitic duplex-microstructured steel.

The plastic co-deformation behavior at the homophase interfaces between the hard nanotwinned grain inclusions and the soft recrystallized matrix grains in a duplex-microstructured AISI 316L austenitic stainless steel is examined through the analysis of long-range orientation gradients within the matrix grains by electron backscatter diffraction and transmission electron microcopy. Our analysis reveals that the mechanical accommodation of homophase interfaces until a macroscopic strain of 22% is realized within a small area of soft grains (about four grains) adjacent to the homophase interface. The activation of deformation twinning in the first two grain layers results in the occurrence of a 'hump' in the orientation gradient profile. We ascribe this effect to the role of deformation twinning on the generation of geometrically necessary dislocations. The smooth profile of the orientation gradient amplitude within the first 10 grain layers indicates a gradual plastic accommodation of the homophase interfaces upon straining. As a consequence, damage nucleation at such interfaces is impeded, resulting in an enhanced ductility of the single phase duplex-microstructured steel.