ABSTRACT
BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes. METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days. RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively). CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors. TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.
Subject(s)
Cerebral Hemorrhage/mortality , Functional Laterality , Aged , Blood Pressure/drug effects , Cause of Death , Cerebral Hemorrhage/physiopathology , Disability Evaluation , Endpoint Determination , Female , Glasgow Coma Scale , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Pilot Projects , Prognosis , Survivors , Treatment OutcomeABSTRACT
Uniform and assembled LaBO3 nanocrystals have been successfully synthesized via a facile hydrothermal method. These assemblies exhibit a rod-shape morphology and each of them consists of small LaBO3 nanocrystals which are tightly attached together. The phase, surface and morphology of these assemblies have been characterized. A possible assembly mechanism of such morphology is also proposed through investigation on the formation process. Photoluminescent spectra suggest that these assemblies doped with Eu3+ can give stronger red emissions than the orange one due to its aragonite structure. Such emission has been explained by the Judd-Ofelt theory. It is expected that these well-defined LaBO3 assemblies could find applications in future luminescent displays and lamps.
Subject(s)
Boron Compounds/chemistry , Europium/chemistry , Lanthanum/chemistry , Luminescent Measurements/methods , Nanotubes/chemistry , Nanotubes/radiation effects , Water/chemistry , Crystallization/methods , Hot Temperature , Materials Testing , Particle SizeABSTRACT
A facile and productive method has been developed to synthesize uniform LaF3 nanocrystals with controllable shapes, including polyhedrons, nanorods and nanoplates. By tuning the amount of NaOH and ligands (oleic acid and octadecylamine), we can finely tailor the shapes and sizes of LaF3 nanocrystals. Three prepared LaF3 nanostructures were well characterized, followed by a series of control experiments to propose a mechanism for the shape control. Based on the success in materials synthesis, controlled patterning of LaF3 nanoplates on substrates has also been achieved. After Yb/Er or Yb/Tm was co-doped in these LaF3 nanostructures, they could serve as nanoparticulate host matrices to give strong upconversion luminescence, showing great potential in biomedical applications considering their small sizes and well-defined shapes.
