ABSTRACT
BACKGROUND: Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only effective treatment, and a five-year survival rate of advanced-stage patients is less than 10%. Hence, exploring immunotherapy is relevant, although GBC immunogenicity is poorly understood. This study examined the relationship between the host immune response and GBC patient survival based on the presence of tumor-infiltrating lymphocytes at different disease stages. METHODS: Tumor tissues from 80 GBC patients were analyzed by immunohistochemistry for the presence of CD3+, CD4+, CD8+, and Foxp3+ T cell populations, and the results were associated with clinical stage and patient survival. RESULTS: The majority of tumor samples showed CD3+ T cell infiltration, which correlated with better prognosis, particularly in advanced disease stages. CD8+, but not CD4+, T cell infiltration correlated with improved survival, particularly in advanced disease stages. Interestingly, a < 1 CD4+/CD8+ T cell ratio was related with increased survival. Additionally, the presence of Foxp3+ T cells correlated with decreased patient survival, whereas a ≤ 1 Foxp3+/CD8+ T cell ratio was associated with improved patient survival. CONCLUSIONS: Depending on the disease stage, the presence of CD8+ and absence of Foxp3+ T cell populations in tumor tissues correlated with improved GBC patient survival, and thus represent potential markers for prognosis and management of advanced disease, and supports testing of immunotherapy.
Subject(s)
CD8-Positive T-Lymphocytes/immunology , Chemoradiotherapy, Adjuvant/mortality , Forkhead Transcription Factors/metabolism , Gallbladder Neoplasms/mortality , Lymphocytes, Tumor-Infiltrating/immunology , Adult , Aged , Female , Follow-Up Studies , Gallbladder Neoplasms/immunology , Gallbladder Neoplasms/pathology , Gallbladder Neoplasms/therapy , Humans , Male , Middle Aged , Prognosis , Survival RateABSTRACT
Objetivo: Reportar un caso de una paciente con enfermedad poliquística renal autosómica dominante(EPRAD) asociada a la presencia de un carcinoma de células transicionales (CCT).Métodos: Paciente de 46 años de edad, con antecedentes de tabaquismo crónico. Se realiza el diagnóstico de EPRAD complicada con hematuria recurrente con origen en la unidad renal derecha. Resultados: Se realiza nefrectomía laparoscópica mano asistida con un tiempo operatorio de 1 hora25 minutos. El informe anatomopatológico de la pieza operatoria es compatible con carcinoma de CCT Grado 1 de Ash, correspondiendo a un estadio T1 N0 M0 de la Clasificación TNM de la AJCCUICCde 1997.Conclusión: Si bien la existencia de neoplasias renales en pacientes portadores de EPRAD constituye una entidad poco común, y que no presenta mayor incidencia que en la población general, debe considerarse como posibilidad diagnóstica en todos aquellos pacientes que evidencien síntomas o signos de complicación de su enfermedad poliquística, sobre todo en aquellos en los que se plantea la resolución quirúrgica de su patología.
Objetive: We report a patient with autosomal dominant polycystic renal disease (ADPRD) associated with transitional cell carcinoma (TCC).Methods: A 46 year old patient with history of chronic cigarette smoking was diagnosed of ADPRD with recurrent hematuria originated in the right renal unit. Results: A right hand-assisted laparoscopic nephrectomy was performed. Operative time was 85minutes. Pathological analysis showed a Grade 1 TCC, pT1 N0 M0.Conclusions: Renal neoplasias in ADPRD patients are infrequent baring the same incidence as normal patients. However, in symptomatic ADPRD patients, renal neoplasias should be kept in mind, especially if patients are to undergo surgery.
Subject(s)
Humans , Female , Middle Aged , Carcinoma, Transitional Cell/surgery , Carcinoma, Transitional Cell/complications , Kidney Neoplasms/surgery , Kidney Neoplasms/complications , Polycystic Kidney, Autosomal Dominant/complications , Laparoscopy , NephrectomyABSTRACT
La malaria es una importante causa de morbimortalidad de países en desarrollo de las zonas tropicales. Sus forma graves de presentación se asocian a una mortalidad del 30%, la mayor proporción debido a P. falciparum. Presentamos el caso de una mujer joven chilena, que luego de viajar a una región endémica, desarrolla sepsis grave seguida por falla orgánica rápidamente progresiva secundaria a malaria por P. falciparum.
Malaria is an important morbidity and mortality cause in non developed tropical countries. Several forms are associated with mortality of 30%, the most part due to P falciparum. We present a young Chilean female case, that after flying to endemic area, developed severe sepsis followed by rapid and progressive organ failure secondary to P.falciparum malaria.