ABSTRACT
Clinical efficacy of sodium nucleospermate (SNS) has shown in the treatment of 26 female patients with chronic endometritis, unsuccessful attempts at in vitro fertilization, and persistent viral infection. Cells from endometrium were processed by liquid cytology and studied by immunocytochemistry techniques. It has been clearly established that, after SNS treatment, the frequency of CD20- and CD56-positive cells was significantly decreased (p < 0.05) and the frequency of TLR4 and TLR9 expressing cells in endometrium has been significantly improved (p < 0.05). In addition, the human papilloma virus (HPV) load was reduced as manifested by the real-time PCR test. The obtained results show good prospects for successful use SNS as a means of pathogenetic therapy in patients with this diagnosis.
Subject(s)
Antiviral Agents/administration & dosage , Endometritis , Endometrium/immunology , Immunologic Factors/administration & dosage , Infertility, Female , Papillomavirus Infections , Antigens, CD20/immunology , CD56 Antigen/immunology , Endometritis/complications , Endometritis/drug therapy , Endometritis/immunology , Endometritis/pathology , Endometritis/virology , Endometrium/pathology , Female , Humans , Infertility, Female/drug therapy , Infertility, Female/etiology , Infertility, Female/immunology , Infertility, Female/pathology , Infertility, Female/virology , Papillomavirus Infections/complications , Papillomavirus Infections/diet therapy , Papillomavirus Infections/immunology , Papillomavirus Infections/pathology , Toll-Like Receptor 4/immunology , Toll-Like Receptor 9/immunologySubject(s)
Antineoplastic Agents, Hormonal/therapeutic use , Aromatase Inhibitors/therapeutic use , Endometrial Neoplasms/drug therapy , Nitriles/therapeutic use , Sarcoma, Endometrial Stromal/drug therapy , Triazoles/therapeutic use , Aged , Anastrozole , Endometrial Neoplasms/diagnostic imaging , Endometrial Neoplasms/pathology , Female , Humans , Remission Induction , Sarcoma, Endometrial Stromal/diagnostic imaging , Sarcoma, Endometrial Stromal/pathology , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
The ability of a series of new 17 alpha-Hydroxyprogesteron derivatives (acetomepregnol, AMOL phenyl propyoate, butagest) in preventing the prostaglandin-induced preterm labor was experimentally studied in mice. It was found that all the synthetic gestagens studied, especially butagest, maintained pregnancy in all test animals on the model of enzaprost F induced abortion. The proposed progestogens can be used to prevent abortion in pregnancies in cases of risk from diseases connected with excess prostaglandin secretion.
