Comparison of the antibacterial effects on subgingival microflora of two different resorbable base materials containing doxycycline.

A study was conducted to evaluate the effects of local drug delivery on subgingival plaque flora using hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) base material containing 40% doxycycline (DOXY). Eleven patients who had at least four pockets exceeding 5 mm in depth associated with a single rooted tooth were selected from volunteers after an initial examination. Two of the pockets were chosen at random for insertion of the HPMC and MC strips twice a week for 6 w. One pocket received no treatment, and the other was debrided and root-planed only. Baseline and follow-up measurements at 0, 1, 3, 6, and 10w included probing depth, gingival shrinkage, bleeding on probing and crevicular fluid flow. Subgingival bacterial samples were also taken for dark-field microscopy. In vitro drug release from the HPMC strips was greater than that from MC. Significant improvements in many clinical parameters occurred in the pockets treated with HPMC or MC strips, or mechanical debridement. There was a marked decrease in the relative proportions of motile organisms during and after treatment.

Use of membranes containing 20% chlorhexidine and 40% doxycycline for treatment of chronic periodontal pockets.

A study was carried out to compare the effects of subgingival applications of resorbable hydroxypropylmethylcellulose (HPMC) membranes containing 20% chlorhexidine (CHx) and 40% doxycycline (DOXY) placed subgingivally in periodontal pockets greater than 5 mm in depth. Each of 11 patients had at least four pockets. HPMC strips containing CHx and DOXY were inserted into each pocket twice a week for 6 w. One pocket was kept as a control and the other received subgingival scaling and root planing at 0, 1, 3 and 6 w. The microbial flora of 44 pockets from the 11 patients was examined using dark-field microscopy at the baseline and at 1, 3, 6 and 10 w. Clinical parameters including probing depth, crevicular fluid flow, bleeding on probing and gingival shrinkage were also recorded. The CHx and DOXY-administered or root-planed pockets showed marked reduction of both pocket depth and the number of motile organisms. Less bleeding was also observed in CHx and DOXY-inserted pockets.

[A clinical study to evaluate the anticalculus effect of a dentifrice on calculus formation]. / Anti-kalkulus özellikli bir dismacununun distasi olusumuna etkisinin klinik degerlendirilmesi.

Calculus plays an important role in chronic inflammatory periodontal diseases. Currently, there is much interest in dentifrices that have the capacity to reduce the formation of calculus. Recent clinical studies have indicated that dentifrices containing soluble pyrophosphate and sodium fluoride can reduce the formation of supragingival calculus. The purpose of this study was to compare the effect on supragingival calculus of a dentifrice containing soluble pyrophosphate and 0.24% sodium fluoride to a placebo dentifrice. Thirty five subjects were stratified into balanced groups based on initial calculus scores. They then received an oral prophylaxis and were assigned to the use of either the placebo or soluble pyrophosphate/sodium fluoride dentifrice for the next 3 months. The results from the 3-month examinations indicated that the dentifrice containing the soluble pyrophosphate and sodium fluoride did not significantly reduce supragingival calculus as compared to the placebo dentifrice. However, both dentifrices reduced the calculus significantly.