[DISLIPOPROTEINEMIA AND HEPATOTOXICITY - OCCUPATIONALLY RELATED PATHOLOGY IN WORKERS OF CHEMICAL PRODUCTION].

The article discusses the development of occupational pathologies of the digestive system and it is associated with dyslipidemia. Selected the most informative indicators for timely identification of metabolic «targets¼ of damage in workers in chemical production of methanol.

[THE SPECIES COMPOSITION OF AGENTS OF COMMUNITY-ACQUIRED INFECTIONS OF URINARY TRACTS AND SENSITIVITY OF MAIN UROPATHOGENS TO ANTIBACTERIAL PREPARATIONS IN MOSCOW IN 2013].

The article presents the results of analysis of spectrum of agents of community-acquired infections of urinary tracts in Moscow The prevalence of resistance these infections to antibiotics applied in treatment of the mentioned pathology are considered.

[Cognitive disorders in workers engaged into formaldehyde and methanol production].

The authors studied cognitive functions state in workers engaged into chemical production under exposure to combination of factors with prevalent methanol and formaldehyde. Study covered 128 examinees of main occupations and 89 individuals of reference group. Through periodic medical examinations, state of cognitive functions was assessed by Montreal scale (MCA). Findings are increased serum levels of methanol and formaldehyde in the main group members. Moderate cognitive disorders of multifunctional type were seen. Associations of these disorders with acting agents were studied, and high degree of their correlations with occupation was revealed.

[Disorders of adaptational resources in workers engaged in methanol and formaldehyde production].

The article presents results of studies concerning human adaptational potential. The authors proved relationships between dysadaptation and influence of methanol and formaldehyde on health of workers engaged into the specific production. The results demonstrate preclinical neurohumoral dysregulation of cardiovascular system. Dysbalance was seen in cardiorespiratory functions, with lower cardiorespiratory index and higher values in respiratory tests. Integral adaptational parameters--adaptational potential and functional state level--that describe complicated structure of interrelationships characterizing functioning level of cardiovascular system, prove stressed regulatory systems and inadequate adaptation of the workers to chemical production conditions. The data obtained enable to use the studied methods for screening examinations to determine workers' health and degree of occupational factors' influences, so early diagnosis of premorbid health disorders is possible.

[Features of dyslipidemia development and insulin resistance in female workers engaged in methanol and formaldehyde production].

The article covers data on analyzing occupational risk of carbohydrate and lipid metabolism in female workers exosed to methanol and formaldehyde. Findings are that increased contents of the studied chemicals in the air of workplace cause more probable dyslipidemia, insuline resistence in peri-menopausal female workers, these disorders have reliable correlation with occupation.

[Immunogenetic features of apoptosis in workers engaged in methanol production].

Disordered cellular death process with inhibition is seen during stress states including occupational activities associated with increased concentrations of methanol in biologic media. Workers exposed to methanol demonstrate prevalence of homozygous type of tumor necrosis factor (TNF) gene and heterozygous variant of cytochrome 450 gene, reliably increased vs reference group. Genetic changes in the main group are associated with reliable decrease in occurrence of transcription protein p53 and TNF receptor, and with altered ratio of intracellular apoptosis factors (bax and bcl-2) towards slower programmed cellular death in chemical production.

[Digestive system diseases in workers engaged into chemical production of methanol and formalin].

The article covers digestive system morbidity in workers engaged into chemical production of methanol and formalin. Blood changes, abnormal blood biochemistry (increased GGT level and GGT/GOT ratio) prove early development of toxic hepatitis. Other finding is increased incidence of liver disorders (diffuse changes proved by ultrasound examination).

[Congenital abnormalities in children whose parents were exposed to methanol and formaldehyde].

The authors proved relationship between congenital abnormalities in children and influence of chemical factors (methanol and formaldehyde production) on the parents. Higher risk of congenital abnormalities was seen: PR = 5.6 (chi2 = 3.54; p = 0.00001), EF = 0.95. These disorders could be connected with work conditions--exceeded MAC for methanol 3.9-fold, that for formaldehyde--2.4-fold.

[Some health parameters of working population in Perm area, and objectives to health improvement for recent years].

The article covers objectives of health preservation, occupational longevity and complex development of industrial medicine in Perm area.

[Proatherogenic and hemodynamic risk factors of occupational arterial hypertension in sailing personel].

The article demonstrates reliably increased risk of arterial hypertension under exposure to general vibration. Lipid metabolism disorders in vibration disease patients were proved to increase risk of atherosclerosis. Recommendations include studies of limbs macrohemodynamics in prophylactic medical examinations among sailing personnel.

[Treatment of intestinal dysbacteriosis in children with diabetes mellitus]. / Lechenie disbakterioza kishechnika u detei, bol'nykh sakharnykh diabetom.

The use of the probiotic Acylact in combination with Viferone containing human recombinant interferon-alpha 2 in the treatment of intestinal dysbacteriosis in children with insulin-dependent diabetes mellitus (IDDM) was shown to be highly efficient. Elimination of microecologic disorders in the intestine was accompanied in all the children by immune rearrangements. The quantity of secretory and serum immunoglobulins and complement increased and the white blood cell chemiluminescence proved to be higher. The correction of the immune status of the children with IDDM resulted in a certain decrease of glycemia. The data are indicative of the fact that such a treatment of intestinal dysbacteriosis in children with IDDM is promising.

[Comparative evaluation of the effectiveness of the treatment of gastroduodenal Campylobacter infection in children]. / Sravnitel'naia otsenka éffektivnosti lecheniia gastroduodenal'nogo kampilobakterioza u detei.

Schemes developed by the authors for antibacterial therapy of gastroduodenal bacterosis caused by Campylobacter spp. in children are described. The data on the treatment of 56 patients with duodenal ulcer and gastroduodenitis are presented. The efficacy of the treatment with medicines under the control of the clinical, endoscopic and microbiological indices was compared. The study showed that De-Nol, furazolidone and combination of trichopol (metronidazole) with vicair were the most efficient drugs for therapy of children with such diseases.

[Qualification requirements for physician-bacteriologists]. / Kvalifikatsionnye trebovaniia k vrachu-bakteriologu.

The authors present the qualification requirements to laboratory physicians specialized in bacteriology. The knowledge and skills of a bacteriologist, necessary for his organizations, methodologic, prophylactic, and diagnostic activities, are listed.

[Isolation of C. pyloridis from children]. / Vydelenie C. pyloridis ot detei.

The authors analyze the findings of gastroduodenal biopsies in 25 children aged 6 to 15 years suffering from mucosal inflammations and functional abnormalities of the upper portions of the digestive tract. Chocolate agar with various bases, one of which has been suggested by the authors, has been used for the isolation of C. pyloridis. Five cultures have been isolated. Microscopic examinations and biochemical identification of the isolates have lead the authors to a conclusion that campylobacter infections of the upper digestive tract may be diagnosed with certainty only after a comprehensive bacteriologic examination.

[Isolation of Campylobacter jejuni and Campylobacter coli from children with acute intestinal diseases]. / Vydelenie Campylobacter jejuni i Campylobacter, coli ot detei s ostrymi kishechnymi zabolevaniiami.

In this work the data obtained in the examination of 338 children with diarrhea, aged 5 days to 14 years, are presented. The methods used for the collection of samples and their storage till the moment of inoculation are described. The possibility of using the microscopic examination of Campylobacter-containing native feces is shown. The work resulted in the isolation of 85 C. jejuni and C. coli strains. As shown in this work, the isolation of Campylobacter depended on the age of children and the season. The etiological importance of Campylobacter for the development of acute enterocolitis and gastroenteritis in 10% of the children under examination is suggested.