[Impact of intermittent hypobaric hypoxia on the thyroid morphofunctional state in experimental hyperthyroidism].

Within 5 days of hypoxia there was an increase in thyroid functional activity, but on days 15-30 there was a decrease in T3 and T4 concentrations and an increase in thyroid-stimulating hormone. Clear correlations were found between the morphometric indices of the thyroid epithelium and the blood concentration of T3 and T4. There was a relationship between the levels of thyroid hormones and the state of the cardiovascular and respiratory systems.

[Morpho-ecological characteristics of thyroid diseases in various regions of Russia and Belorussia from surgical data]. / Morfoékologicheskaia kharakteristika zabolevanii shchitovidnoi zhelezy v razlichnykh regionakh Rossii i Belorussii po dannym operatsionnogo materiala.

Thyroid lesions were histologically studied on surgical material obtained in 1992-1996 in 12 regions of Russian Federation and Republic of Belarus. Various forms of thyroid pathology were considered with reference to local ecological situation. An increase of thyroid carcinoma incidence and particularly that of papillary carcinoma was observed in regions with radiation pollution (Chelyabinsk and Bryansk regions). A high degree of correlation exists between the incidence of various forms of thyroid pathology and radiation situation. This is also true for pollution of sewage and the presence of ferrous metallurgy factories. No correlation was found with the pollution of atmosphere.

[An experimental model of enteric klebsiellosis]. / Eksperimental'naia model' kishechnogo klebsielleza.

Acute enteric infection was reproduced in rabbits, used as an experimental model, receiving Aspergillus flavus metabolites with food for 15 days and inoculated rectally with enterotoxigenic strain Klebsiella pneumoniae K24 6723. Pathomorphological study revealed the penetration of Klebsiella into microplicate cells of the intestinal epithelium, the proliferation of bacteria in the lamina propria and in the cupolas of Peyer's patches, as well as in phagolysosomes of leukocytes and macrophages. The lesion of the mucous membrane in both large and small intestine, accompanied by the hyperplasia of lymphoid follicles, was noted. As a rule, surface epithelium was dystrophically changed and peeled off into the lumen of the intestine. The specificity of such lesion was confirmed by the detection of Klebsiella in Coons' direct immunofluorescence test. The experimental model confirmed the role of a decrease in immunological protective reactions of the body, caused the action of A.flavus metabolites, in the development of the infectious process, initiated by opportunistic enterobacteria.

[Morphological characteristics of the pituitary-gonad system in high altitude hypoxia]. / Morfologicheskaia kharakteristika gipofizarno-gonadnoi sistemy pri deistvii na organizm vysokogornoi gipoksii.

The experiments on male rats showed that their sojourn at high altitude resulted in alterations of functional relationship between the gonadotropic pituitary cells and tests. That was characterized by synthesis inhibition and hormone release by gonadotropocytes. In the testes we found impairments in the barrier function and active substance transport in sustentocytes. Intensification of destructive processes in sustentocytes, with prolongation of adaptation duration, are mediated to a greater extent by a direct destructive high altitude factors. A decrease in hormone producing function of glandulocytes as a result of destruction processes has aggravated dysharmony of the pituitary-testes system which by the end of the second month was manifested by a marked inhibition of gonadotropic cell hormone release with preservation of the synthesis high level in them.

[The structural reorganization of the calcium-regulating glands in body adaptation to high altitude]. / Strukturnaia perestroika kal'tsiireguliruiushchikh zhelez pri adaptatsii organizma k vysokogor'iu.

The parathyroid cells and thyroid C-cells were studied morphologically, morphometrically and electron microscopically at the altitude of 3200 m. The increase of functional activity of both parathyroid cells and thyroid cells was observed starting from the 7th day of being at the high altitude. This was manifested in the increase of C-cell number, their size and ultrastructurally in the cell organelles hyperplasia and hypertrophy. As distinct from the normal altitude, high activity of the parathyroid cells was not compensated by an increased function of C-cells, this dysfunction resulting in a high blood level of calcium which may serve as a criterion of this hormonal system adaptivity and as an index of a new level of calcium homeostasis.

[Clinical pathomorphology of the liver and gastric mucosa in peptic ulcer complications]. / Klinicheskaia patomorfologiia pecheni i slizistoi obolochki zheludka pri oslozhneniiakh iazvennoi bolezni.

Tests of the functional state of the liver and indices of the immuno-biological reactivity were studied in 193 patients with complicated forms of the ulcerous disease. The intravital morphological investigation of the liver and gastric mucosa tissues was performed. The correlative relations between the character of changes in the stomach and liver and processes of autoallergy were detected. The comparison of different parameters enabled most informative indices to be revealed.