ABSTRACT
To assess the pharmacotherapy of elderly patients with chronic heart failure (CHF), by studying the effect of perindopril, lozartan potassium and their combination on the severity of clinical symptoms, hemodynamics, exercise capacity and heart morphofunctional parameters, 78 patients with chronic heart failure II-IV FC (for classification NYHA), complicating the course of coronary heart disease (CHD) with left ventricular ejection fraction ≤45 % were examined. Men were 42 (53,8 %), women - 36 (46,2 %), mean age 64,8±3,7 years. The study revealed that the background as long-term monotherapy with perindopril and lozartan potassium in patients with CHF complicating CHD, CHF FC decreased significantly and significantly increased left ventricular ejection fraction (p < 0,05). The combined treatment with perindopril and lozartan potassium showed no advantage over monotherapy with these agents. These patients showed a decrease in the frequency of angina attacks by 28,5 and 27 % respectively (p < 0,05) only after a long course of treatment with perindopril and the combination of perindopril and lozartan potassium.
Subject(s)
Coronary Disease/complications , Heart Failure/drug therapy , Hemodynamics/drug effects , Losartan/administration & dosage , Perindopril/administration & dosage , Stroke Volume/drug effects , Aged , Angiotensin II Type 1 Receptor Blockers/administration & dosage , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Drug Monitoring/methods , Drug Therapy, Combination/methods , Female , Heart Failure/diagnosis , Heart Failure/physiopathology , Humans , Male , Severity of Illness Index , Treatment OutcomeABSTRACT
This pharmacoepidemiological study at the regional level permitted to reveal the real strategy of medical prescriptions and the choice of medications for the treatment of bronchial asthma and chronic obstructive respiratory disease. Regional variations in the combination of preparations actually used by patients with these diseases are investigated for the first time. The main causes of non-compliance with medical prescriptions are analysed.
Subject(s)
Asthma/drug therapy , Delivery of Health Care , Health Facilities , Pharmaceutical Preparations/supply & distribution , Physician's Role , Pulmonary Disease, Chronic Obstructive/drug therapy , Adult , Humans , Middle Aged , Physician-Patient Relations , Russia , Surveys and QuestionnairesABSTRACT
The study was designed to estimate quantitative and qualitative characteristics of drug consumption for therapy of bronchial asthma and chronic obstructive pulmonary disease in outpatient and inpatient facilities. The frequency and intensity of the use of selected drugs are considered in terms of their conformity to principles of evidence-based medicine. Analysis of prescriptions revealed different degree of awareness of district physicians and other specialists about rational drug therapy. The drawbacks of the treatment of bronchial asthma and chronic obstructive pulmonary disease are first and foremost attributable to poor compliance with the existing standards and inefficient use of medications. It was shown that each outpatient and inpatient facility has its own policy of fund allocation for pharmacotherapy. The results of the study can be useful for rational organization of the treatment of patients with bronchial asthma and chronic obstructive pulmonary disease and for optimization of medical aid provision with a view to saving healthcare resources.
Subject(s)
Asthma/drug therapy , Pulmonary Disease, Chronic Obstructive/drug therapy , Adolescent , Adult , Aged , Ambulatory Care Facilities , Evidence-Based Medicine , Female , Humans , Male , Middle Aged , Young AdultABSTRACT
The content of basic fibroblast growth factor (bFGF) and also interleukins 1beta and 6 (IL-1beta and IL-6) has been investigated in rat buccal mucosa after its surgical injury by an erbium laser (Er:YAG laser) and a scalpel. The laser emission caused a sharp increase in the content of these regulators on the second day after treatment followed by decrease observed on the seventh day. These results may reflect synergistic effect of these peptide regulators in the wound defect. Changes in time-course of bFGF, IL-1beta and IL-6 release in the wound formed by the laser beam compared with the wound induced by the cutting instrument may promote earlier appearance of the proliferation phase.
Subject(s)
Fibroblast Growth Factor 2/metabolism , Interleukin-1beta/metabolism , Interleukin-6/metabolism , Mouth Mucosa/physiology , Wound Healing , Animals , Lasers, Solid-State , Male , Mouth Mucosa/surgery , Oral Surgical Procedures/methods , RatsABSTRACT
In experiment on 12 Chinchilla rabbits dynamics of reparative regeneration was studied at the terms 2 and 4 months. Bone defect in mandible corner was closed by osteoplastic material Gapkol which was covered from inside by allogenic or autologic stem cells received from rabbit adipose tissue. The results of the ray tracing methods of study were verified by SEM and histological methods.
Subject(s)
Bone Regeneration , Collagen , Dental Materials , Durapatite , Mandible/surgery , Mesenchymal Stem Cell Transplantation , Osteogenesis , Adipose Tissue , Animals , Drug Combinations , Follow-Up Studies , Mesenchymal Stem Cells/cytology , Microscopy, Electron, Scanning , Osteosclerosis/surgery , Rabbits , Time Factors , Tomography, X-Ray Computed , Transplantation, Autologous , Transplantation, HomologousABSTRACT
In experiment on 16 grown-up chinchilla rabbits the dynamic of reparative regeneration was evaluated by digital microfocal rontgenography in the terms of 1, 2 and 4 months. Bone defect of the 8capital CHE, Cyrillic8 mm size in the region of mandible angle was caused by surgical laser Smart 2940 D+ on the right side and by physiodespenser Surgec XT on the left side. Surgical laser use let to reduce intact mother bone traumatisation and to improve remote results of bone tissue regeneration. After bone defect creation bone tissue regeneration was put into effect by all 3 callus types - endosteal, periosteal and intermediary.
Subject(s)
Bone Regeneration , Mandibular Fractures , Tomography, X-Ray Computed/methods , Animals , Bony Callus , Chinchilla , Follow-Up Studies , Lasers , Mandibular Fractures/diagnostic imaging , Mandibular Fractures/etiology , Time FactorsABSTRACT
Digital microfocal x-ray study was experimentally studied in animals to examine the time course of changes in their bone regeneration. Sixteen Chinchila rabbits whose bone defect in the angle of the mandibular ramus had been closed with the osteoplastic material Gapcol with the applied allogeneic, autologous stem cells isolated from rabbit adipose tissue and human plasma enriched with thrombocytic growth factors were examined. The capabilities of digital microfocal x-ray study versus x-ray computed tomography were compared in the evaluation of reparative regeneration of bone tissue. The results of radiation studies were verified with the data of scanning electron microscopy.
Subject(s)
Bone Regeneration , Bone and Bones/diagnostic imaging , Bone and Bones/physiology , Radiographic Image Enhancement/methods , Animals , Humans , Rabbits , Tomography, X-Ray ComputedABSTRACT
For one hundred fifty eight patients with chronic obstructive pulmonary disease (COPD) were the subjects of a pharmacoepidemiological study. The study found that both pharmaceuticals indicated for the treatment of this disease, and drugs of low effectiveness, were used in treatment of these patients very intensively. Each hospital led its own policy of the distribution of expenses associated with COPD treatment.
Subject(s)
Drug Therapy/methods , Drug Therapy/statistics & numerical data , Pulmonary Disease, Chronic Obstructive/drug therapy , Pulmonary Disease, Chronic Obstructive/epidemiology , Catchment Area, Health , Drug Therapy/classification , Humans , Incidence , Prevalence , Russia/epidemiologyABSTRACT
The paper describes the technique of plasma spraying used to fortify the coating of permanent dentures. This method helps improve the quality of permanent dentures and strengthen the adhesion of coatings on retention layers. Hence, dentures with very thin retention layer and vary strong coating adhesion can be made by traditional methods of denture making, thus improving the quality of prosthetic treatment. Traditional plastic may be used as coating material.
