1.
Bioorg Med Chem Lett
; 12(8): 1181-4, 2002 Apr 22.
Article
in English
| MEDLINE
| ID: mdl-11934583
ABSTRACT
The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compounds. By correctly selecting the combination of P1 and P3 residues, high levels of potency, selectivity and in vivo efficacy were obtained.