ABSTRACT
Bullous pemphigoid (BP) is an autoimmune, acquired, cutaneous disease caused by the production of autoantibodies against hemidesmosomes' components in the basement membrane. The estimated incidence in Europe ranges from 7 to 43 cases per million inhabitants per year. Several studies have reported an association between BP and neurological disorders (ND). Our cohort of Bullous pemphigoid and ND is the first in Brazil and showed a significantly high prevalence of neurological and/or psychiatric diseases, especially cerebrovascular accident (CVA) and dementia, in agreement with the prevalence reported in several studies published in the medical literature in recent years.
Subject(s)
Nervous System Diseases/epidemiology , Pemphigoid, Bullous/epidemiology , Adult , Age Distribution , Age Factors , Aged , Aged, 80 and over , Brazil/epidemiology , Female , Humans , Male , Middle Aged , Nervous System Diseases/complications , Pemphigoid, Bullous/complications , Prevalence , Retrospective Studies , Sex Distribution , Stroke/complications , Stroke/epidemiologyABSTRACT
Pigmented Bowen's disease is rare, though more prevalent in men. It presents as a well-delineated plaque in areas unexposed to sun. There are reports of association with seborrheic keratosis, solar lentigo or exuberant pigmentation of genital and intertriginous regions. A specific dermoscopy finding is the presence of brown or gray dots in regular arrangement and coiled or dotted vessels. Thus, we aim to raise awareness of the diagnosis of pigmented Bowen's disease in pigmented lesions.
Subject(s)
Bowen's Disease/pathology , Pigmentation Disorders/pathology , Skin Neoplasms/pathology , Aged , Dermoscopy , Epidermis/pathology , Humans , Keratosis, Seborrheic/pathology , MaleABSTRACT
Pigmented Bowen's disease is rare, though more prevalent in men. It presents as a well-delineated plaque in areas unexposed to sun. There are reports of association with seborrheic keratosis, solar lentigo or exuberant pigmentation of genital and intertriginous regions. A specific dermoscopy finding is the presence of brown or gray dots in regular arrangement and coiled or dotted vessels. Thus, we aim to raise awareness of the diagnosis of pigmented Bowen's disease in pigmented lesions.
